Research Interests
Proteins of Innate immunity including complement, C-reactive protein and serum amyloid P component. The role of these proteins in the response to tissue damage, in systemic autoimmunity and in host defense against bacterial infection.
Selected Publications
Link to PubMed
Stein, M-P., J.C. Edberg, R.P. Kimberly, E.K. Mangan, D. Bharadwaj, C.
Mold, and T.W. Du Clos. 2000. C-reactive protein binding to FcγRIIa on
human monocytes and neutrophils is allele specific. Journal of Clinical
Investigation. 105:369-376.
Mold, C., B. Rodic-Polic, T.W. Du Clos. 2002. Protection from
Streptococcus pneumoniae infection by C-reactive protein and natural
antibody requires complement but not Fcγ receptors. Journal of
Immunology 169:7019-7025.
Mold, C., R. Baca, T.W. Du Clos. 2002. Serum amyloid P component and
C-reactive protein opsonize apoptotic cells for phagocytosis through
Fcγ receptors. Journal of Autoimmunity 19:147-154.
Mold, C, W. Rodriguez, B. Rodic-Polic, and T.W. Du Clos. 2002.
C-reactive protein mediates protection from lipopolysaccharide through
interactions with Fcγ receptors. Journal of Immunology 169:7109-7125.
Rodriguez, W., C. Mold, M. Kataranovski, J. Hutt, LL. Marnell, and T.W.
Du Clos. 2005. C-reactive protein reverses ongoing lupus nephritis.
Arthritis and Rheumatism, 52:642-650.
Bang, R., L.L. Marnell, C. Mold, M.P. Stein, K. Du Clos, C.
Chivington-Buck, and T.W. Du Clos. 2005. Overlap of Human FcγRI,
FcγRIIa, and C1q binding sites in C-reactive protein as determined by
site-directed mutagenesis. Journal of Biological Chemistry,
280:25095-25102.
Rodriguez, W., C. Mold, L.L. Marnell, J. Hutt, G. J. Silverman, D.
Tran, and T. W. Du Clos. 2006. Prevention and reversal of
nephritis in MRL/lpr mice with a single injection of C-reactive
protein. Arthritis and Rheumatism, 54:325-335.
Mold, C. and T.W. Du Clos. 2006. C-reactive protein increases cytokine
responses to Streptococcus pneumoniae through interactions with Fcγ
receptors. Journal of Immunology, 176:7598-7604.
Rodriguez, W., C. Mold, M. Kataranovski, J.A. Hutt, L.L. Marnell, J.S.
Verbeek, and T.W. Du Clos. 2007. C-reactive protein-mediated
suppression of nephrotoxic nephritis: Role of macrophages, complement
and Fcγ receptors. Journal of Immunology, 178:530-538.
Thomas-Rudolph, D., T.W. Du Clos, C.M. Snapper, and C. Mold. 2007.
C-reactive protein enhances immunity to Streptococcus pneumoniae by
targeting uptake to FcγR on dendritic cells. Journal of Immunology,
178:7283-7291.
