Research Interests
Selected Publications
O’Rourke JP and Ness SA. Lineage Specific Alternate Splicing Produces Multiple Forms of c-Myb with Unique Transcriptional Activities. Manuscript in preparation.
Liu F, Lei W, O’Rourke JP, Ness SA. Oncogenic Mutations Cause Dramatic, Qualitative Changes in the Transcriptional Activity of c-Myb. Oncogene. 2006 Feb 2;25(5):795-805.
O’Rourke JP, Olsen JC, Bunnell BA. Optimization of Equine Infectious Anemia Derived Vectors for Hematopoietic Cell Lineage Gene Transfer. Gene Ther 2005 Jan;12(1):22-29.
O’Rourke JP, Hiraragi H, Urban K, Patel M, Olsen JC, Bunnell BA. Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors. Mol Ther. 2003 May;7(5):632-9.
O’Rourke JP, Newbound GC, Kohn DB, Olsen JC, Bunnell, BA. Comparison of Gene Transfer Efficiency and Gene Expression with EIAV and HIV-1 Derived Lentivirus Vectors. J. Virology. 2002 Feb;76(3): 1510-1515.
O'Rourke JP, Tarantal AF, Case SS, Newbound GC, Li J, Lee CI, Baskin CR, Kohn DB, Bunnell BA. Rhesus monkey model for fetal gene transfer: studies with retroviral- based vector systems. Mol Ther 2001 Feb;3(2):128-38.
Newbound GC, Cooper JR, O'Rourke JP, Baskin CR, Bunnell BA. Analysis of gene transfer efficiency of retrovirus producer cell transplantation for in situ gene transfer to hematopoietic cells. Exp Hematol 2001 Feb;29(2):163-73.
Newbound GC, O'Rourke JP, Collins ND, Andrews JM, DeWille J, Lairmore MD. Repression of tax-mediated human t-lymphotropic virus type 1 transcription by inducible cAMP early repressor (ICER) protein in peripheral blood mononuclear cells. J Med Virol 2000 Oct;62(2):286-92.
Hutt JA, O'Rourke JP, DeWille J. Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland. J Biol Chem 2000 Sep 15;275(37):29123-31.
O'Rourke JP, Hutt JA, DeWille J. Transcriptional regulation of C/EBP delta in G0 growth-arrested mouse mammary epithelial cells. Biochem Biophys Res Commun 1999 Sep 7;262(3):696-701.
O'Rourke JP, Newbound GC, Hutt JA, DeWille J. CCAAT/enhancer-binding protein delta regulates mammary epithelial cell G0 growth arrest and apoptosis. J Biol Chem 1999 Jun 4;274(23):16582-9.
Newbound GC, O'Rourke JP, Collins ND, DeWille J, Lairmore MD. Comparison of HTLV-I basal transcription and expression of CREB/ATF-1/CREM family members in peripheral blood mononuclear cells and Jurkat T cells. J Acquir Immune Defic Syndr Hum Retrovirol 1999 Jan 1;20(1):1-10
Werkmeister JR, Blomme EA, Weckmann MT, Grone A, McCauley LK, Wade AB, O'Rourke JP, Capen CC, Rosol TJ. Effect of transforming growth factor-beta1 on parathyroid hormone-related protein secretion and mRNA expression by normal human keratinocytes in vitro. Endocrine 1998 Jun;8(3):291-9.
O'Rourke JP, Yuan R, DeWille J. CCAAT/enhancer-binding protein-delta (C/EBP-delta) is induced in growth-arrested mouse mammary epithelial cells. J Biol Chem 1997 Mar 7;272(10):6291-6.
Newbound GC, Andrews JM, O'Rourke JP, Brady JN, Lairmore MD. Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes. J Virol 1996 Apr;70(4):2101-6.
