John Lauriello, M.D.Professor and Vice ChairExecutive Medical Director, UNM Psychiatric Center
Dr. Lauriello’s academic interest is in the diagnosis and treatment of psychotic disorders most notably schizophrenia. He is the director of the Schizophrenia Research Group which focuses on clinical trials and neuroimaging. Dr. Lauriello has welcomed resident participation in his research work and currently has several residents working on a variety of projects. For the interested resident there is a possibility for dedicated research time in the 4th year with his group. Original research or scholarly articles in refereed journals: Bustillo J, Rowland LM, Jung R, Brooks WM Qualls C, Hammond R, Hart B, Lauriello J Proton Magnetic Resonance Spectroscopy During the First Year of Antipsychotic Treatment in Schizophrenia Patients with Minimal Medication Exposure: A Longitudinal Study (Submitted) Bustillo J, Barrow R, Paz R, Tang J, Seraji-Bozorgzad N, Moore G, Bolognani F, Lauriello J, Perrone-Bizzozero N, Matthew P Galloway M. Long term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels, Neuropsychopharmacology August 2005, Rowland L, Bustillo J, Mullins P, Jung R, Lenroot R, Landgraf E, Barrow R, Yeo R, Lauriello J, Brooks W. The effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4.0T proton magnetic resonance spectroscopy study, Am J Psychiatry, 162(2):394-396 Feb 2005 Lasser R, Turner M, Lauriello J. New Treatments in Schizophrenia: Long Acting Risperidone Psychiatric Annals (accepted) Rowland L, Astur R, Jung R, Bustillo J, Lauriello J, Yeo RA. Selective Cognitive Impairments Associated with NMDA Receptor Blockade in Humans. Neuropsychopharmacology. 30, 633-639 2005 Lauriello J, McEvoy JP, Rodriquez S. Bossie CA, Lasser R Long-Acting Risperidone vs. Placebo in the Treatment of Hospital Inpatients with Schizophrenia Schizophrenia Research 72 249-258 Jan 2005 Bustillo J, Wolff C, Myers-y-Gutierrez A, Todd S, Dettmer TS, Cooper, TB, Allan A, Lauriello J, Valenzuela F, Treatment of Rats with Antipsychotic Drugs: Lack of an Effect on Brain N-acetyl aspartate Level Schizophrenia Research Schizophrenia Research 66(1):31-39 Jan 2004 Mullins P, Rowland L, Bustillo J, Bedrick E, Lauriello J, Brooks, W. Valenzuela F, Reproducibility of 1H-MRS measurements in schizophrenic patients Magnetic Resonance in Medicine Magnetic Resonance in Medicine 50 (4) 704-707 Oct 2003 Lenroot, R, Bustillo J, Lauriello J, Keith S Integrated Treatment of Schizophrenia Psychiatric Services Vol 54 No. 11 2003 Bustillo J, Lauriello J, Parker K, Hammond L, Rowland L, Bogenschutz M, Keith S, Treatment of Weight Gain with Fluoxetine in Olanzapine Treated Schizophrenic Outpatients Neuropscyhopharmacology 28(3) 527-529, 2003 Nurnberg G, Hensley P, Gelenberg A, Fava M, Lauriello J, Paine S. Treatment of antidepressant-associated sexual dysfunction with sildenafil: A randomized controlled trial. JAMA 289:1,2003. Bustillo J, Lauriello J, Rowland L, Thomson L, Petropoulus H, Hammond R, Hart B, Brooks W. Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposure, Schizophrenia Research,58:313-321, 2002 Roberts, LW, Warner T, Brody J, Roberts B, Lauriello J, Lyketsos C Patient and Psychiatrist Ratings of Hypothetical Schizophrenia Research Protocols: Assessment of Harm Potential and Factors Influencing Participation Decisions Am J Psychiatry 159:4 573-584 2002 Bustillo J, Rowland L, Lauriello J, Pertropoulus H, Hammond R, Hart B, Brooks W Elevated Choline Concentrations in the Caudate Nucleus in Antipsychotic-Naïve Patients with Schizophrenia Am J of Psychiatry American Journal of Psychiatry 159:130-133 2002 Bustillo J, Lauriello J, Rowland L, Jung R, Pertropoulus H, Hart B, Blanchard J, Keith S, Brooks W, Effects of Chronic Haloperidol and Clozapine Treatments on Frontal and Caudate Neurochemistry in Schizophrenia Psychiatry Research: Neuroimaging 107 135-149 2001 Lauriello J, Bustillo J Medication Treatments for Schizophrenia: Translating Research Findings into Better Outcomes J. of Psychiatric Practice Vol 7 No.4 260-265 July 2001 Krakow B, Hollifield M, Johnston l, Koss M, Schrader R, Warner TD, Tandberg D, Lauriello J, McBride L, Cutchen l, Cheng D, Emmons S, Germain A, Melendrez D, Sandoval D, Prince H. A randomized controlled study of imagery rehearsal therapy for chronic nightmares in sexual assault survivors with posttraumatic stress disorder JAMA Vol 286 No 5 537-545 August 2001 Hoff A L, Faustman W O, Wieneke M, W.S. Kremen W S, Blankfeld H, Lauriello J, Sullivan E V, Lim K O, Pfefferbaum A. The Relationship of Estrogen to Brain Morphology in Female Patients with Schizophrenia Am J Psychiatry 158:1134-1139 July 2001 Roberts LW, Lauriello J, Geppert C, Keith SJ Placebos and Paradoxes in Psychiatric Research: An Ethics Perspective, Biological Psychiatry 49:887-893, 2001 Yager J, Lauriello J Images of the Mind [Editorial] Seminars in Clinical Neuropsychiatry, Vol6 No 2 April 79-81 2001 Rowland L, Bustillo J, Lauriello J Proton Magnetic Resonance Spectroscopy (1H-MRS) Studies of Schizophrenia Seminars in Clinical Neuropsychiatry, Vol6 No 2 April 2001 121-130 Lauriello J, Bustillo J, Horan W.P., Keith S Considering the Patient with First Episode Psychosis, Journal of Psychiatric Practice Vol 7 No2. 123-132 March 2001 Bustillo J, Lauriello J, Horan W, Keith SJ The Psychosocial Treatment of Schizophrenia; An Update, Am J. of Psychiatry 158(2) 163-175 Feb. 2001 Lauriello J, Bustillo J, Keith S Can Intensive Psychosocial Treatments Make a Difference in a Time of Atypical Antipsychotics and Managed Care, Schiz Bull Vol 26 No1, 141-144, 2000 Nurnberg H, Hensley P, Lauriello J Sildenafil in the Treatment of Sexual Dysfunction Induced by Selective Serotonin Reuptake Inhibitors, CNS Drugs 13(5) 321-335 May 2000 Krakow B, Hollifield M, Schrader R, Koss M, Tandberg D, Lauriello J, McBride L, Warner T, Cheng D, Edmond T, Kellner R A Controlled Study of Imagery Rehearsal for Chronic Nightmares in Sexual Assault Survivors with PTSD, J. Traumatic Stress 13 (4) 589-609 Oct 2000, Lauriello J, Bustillo J, Keith S. A Critical Review of Research on Psychosocial Treatment of Schizophrenia, Biological Psychiatry 46:1409-1417 Nov 1999 Nurnberg H, Lauriello J,Hensley P, Parker L, Keith S Sildenafil for Sexual Dysfunction in Women Taking Antidepressants [letter], Am J of Psychiatry 156:10, Oct. 1999 Nurnberg H, Hensley P, Lauriello J,Parker L, Keith S Sildenafil for Antidepressant Induced Sexual Dysfunction in Female Patients, Psychiatric Services, Vol 50 No.8 : 1076-1078, 1999 Blanchard J, Squires D, Henry T, Horan W, Bogenschutz M, Lauriello J, Bustillo J Examining an Affect Regulation Model of Substance Abuse in Schizophrenia: The Role of Traits and Coping, J Nerv Ment Dis 187:72-79, 1999 Bustillo J, Lauriello J, Keith S Schizophrenia: Improving Outcome, Harvard Rev of Psychiatry 6:229-240 1999 Nurnberg H, Lauriello J, Hensley P, Parker L, Keith S Sildenafil for Iatrogenic Serotonergic Antidepressant Medication Induced Sexual Dysfunction in 4 Patients, Journal of Clin Psychiatry 60:1 p.33-35 Jan 1999 Lauriello J, Mathalon D, Rosenbloom M, Sullivan E, Faustman W, Ringo D, Lim KO, Pfefferbaum A Association Between Regional Brain Volumes and Clozapine Response in Schizophrenia Biol. Psychiatry 43(12) 879-886 June 1998 Lauriello J, Sullivan E, Lim KO, Faustman W, Hoff A, Pfefferbaum A Similar Extent of Brain Dysmorphology in Severely Ill Women and Men with Schizophrenia American Journal of Psychiatry 154 (6) 819-825 June 1997 Faustman W O, Ringo D, Lauriello J, Lim K, Pfefferbaum A, Bardgett M, Csernansky J. Effects of Seroquel (ICI204, 636) On Platelet Serotonin-2 Binding in Schizophrenia (Letter to the Editors) Journal of Clinical Psychopharmacology Vol 16/No.6 464-466 Dec. 1996 Benson K.L., Sullivan E.V., Lim K.O., Lauriello J., Zarcone V.P., Pfefferbaum A. Slow Wave Sleep and Computed Tomographic Measures of Brain Morphology in Schizophrenia Psychiatry Research 60 125-134 1996 Gillin J C, Lauriello J, Kelsoe J, Rapaport M. Golshan S, Kenny W, Sutton L. No Antidepressant Effect of Biperiden Compared with Placebo in Depression: A Double-Blind 6 week Clinical Trial Psychiatry Research 58 (2): 99-105 1995 Sept. Lauriello J, Kenny W, Sutton L, Golshan S, Ruiz C, Kelsoe J, Rapaport M, Gillin JC The Cholinergic REM Sleep Induction Test with Pilocarpine in Depressed and Normal Controls Biol. Psychiatry 1993 Jan, Vol. 33; 33-39 Lauriello J, Jeste D. Neuroleptic Treatment of Schizophrenia. Comprehensive Therapy 1992:18 (1) 30- 35
Books, Chapters and Review Articles: Lauriello J and Keith S. Long Acting Antipsychotics: Using IM Antipsychotics: Lessons from Clinical Practice Currents Psychiatry April 2005 Lauriello J, Bustillo J, Keith SJ, Schizophrenia Scope of the Problem ” in Sadock and Sadock’s Comprehensive Textbook of Psychiatry, Lippincott Williams and Wilkins,2005. Csernansky J and Lauriello J. Editors: Atypical Antipsychotics from Bench to Bedside: Marcel Dekker 2004 Lenroot R, Lauriello J, The Nosology of Psychotic Disorders in Atypical Antipsychotics From Bench to Bedside Marcel Dekker 2004 Lauriello J, Editor FOCUS: The Journal of Lifelong Learning in Psychiatry: Schizophrenia Winter 2004 Volume II Number 1. Lauriello J, Bustillo J, Schingler K, “ The First Interview of a Patient with Psychosis: Symptoms, Safety and Stabilization Focus The Journal of Lifelong Learning in Psychiatry: Schizophrenia Winter 2004 Volume II Number 1. Lauriello J, Lenroot R, Bustillo J, “Maximizing the Synergy Between Pharmacotherapy and Psychosocial Therapies for Schizophrenia” Schizophrenia: Contemporary Clinical Perspectives The Psychiatric Clinics of North America Vol. 26 No.1 W.B Saunders Company 2003 Yager J, Lauriello J, M.D. Editors Seminars in Clinical Neuropsychiatry: Emerging Neuropsychiatry of Brain-Behavior Relationships 2001 Lauriello J, Horan WP, Bustillo J, “Schizophrenia from the Life-Cycle Perspective” Schizophrenia: A New Guide for Clinicians, Marcel Dekker, Inc. 2001 Lauriello J, Erickson B, Keith SJ, “Schizoaffective Disorder, Schizophreniform Disorder and Brief Psychotic Disorder” in Kaplan and Sadock’s Comprehensive Textbook of Psychiatry, Lippincott Williams and Wilkins Nov. 1999. Bustillo J, Lauriello J, Keith SJ, “Schizophrenia: Psychosocial Treatment” in Kaplan and Sadock’s Comprehensive Textbook of Psychiatry, Lippincott Williams and Wilkins Nov 1999. Lauriello J. and Keith S.J., "Psychosocial Treatment of Schizophrenia" in Current Psychiatric Therapy II editor Dunner D.L., W.B. Saunders 1997 Marsh L, Lauriello J, Sullivan E, Pfefferbaum A. "Neuroimaging in Psychiatric Disorders" in Neuroimaging II: Clinical Applications, editor Erin Bigler, Plenum Press, New York 1996
Investigator
Initiated Grant Funding: Pharmaceutical Trials Funding A Double-Blind Randomized Study Comparing Intramuscular Olanzapine Depot with Placebo in the Treatment of Patients with Schizophrenia. J. Lauriello P.I. Eli Lilly 2004 to present A Study of Two Doses of Galantamine HBR as an Adjunctive Treatment to Risperdal in Male Outpatients with Schizophrenia and Associated Cognitive Deficits J. Lauriello P.I., Johnson and Johnson Pharmaceutical Research and Development, L.L.C. 2003 to present. Ris-USA-305 An Open-Label Study of the Efficacy and Safety of Risperdal Long-Acting Microspheres (Risperdal Consta) Administered Once Monthly in Adults with Schizophrenia or Schizoaffective Disorder J. Lauriello P.I. Janssen Pharmaceutica, 2002-2004 A Multicenter, Randomized, Double-Blind Study of Flexible Doses of Aripiprazole Versus Perphenazine in the Treatment of Patients with Treatment Resistant Schizophrenia J. Lauriello P.I. Bristol Myers Squibb Phamaceutical Research Institute 2001-2003 Double-Blind Placebo Controlled Study of Sildenafil for Antidepressant Induced Sexual Dysfunction H.G. Nurnberg P.I., Lauriello J, Hensley P Pfizer Pharmaceutical ILP3004 “A randomized, double-blind, placebo- and risperidone-controlled, multicenter study to evaluate the efficacy and safety of two nonoverlapping dose ranges of iloperidone given b.i.d. for 42 days to schizophrenic patients with acute or subacute exacerbation, followed by a risperidone-controlled, long-term treatment phase with iloperidone given q.d.” J. Lauriello P.I. Novartis Pharmaceuticals Inc. 1999-2002 RIS 121and RIS 196 Risperidone Depot vs. Placebo in the Treatment of Subjects with Schizophrenia or Schizoaffective Disorder J. Lauriello P.I., Janssen Pharmaceutica 2000-present Differential Effects of Exposure to Iloperidone and Risperidone in Schizophrenia: A Longitudinal Proton-Magnetic Resonance Spectroscopy Evaluation An Amendment to: Novartis Study ILP3004 - J. Lauriello and J. Bustillo P.I. Novartis Pharmaceuticals Inc. 1999-2000 RIS-INT-35 Double-blind Evaluation of Oral Risperidone vs. Haloperidol on the Long Term Morbidity of Early Psychotic Patients J. Lauriello P.I. Janssen Pharmaceutica 1996- present RIS INT-50 Risperidone vs. Olanzapine in the Treatment of Schizophrenia in elderly subjects J. Lauriello P.I. Janssen Pharmaceutica 1998- 1999 RIS USA 112 and 113 Risperidone vs. Olanzapine in the Treatment of Schizophrenia J. Lauriello P.I. Janssen Pharmaceutica 1997- 1999 Study M95-372 A Double Blind, Randomized, Comparison of the Safety and Efficacy of Sertindole and Risperidone in Treatment Resistant Schizophrenic Patients J. Lauriello P.I. Abbott Pharmaceuticals, Inc. 1996-1998 A Dose Ranging Study of the Efficacy and Tolerability of OPC-14597 in Acutely Relapsing Hospitalized Schizophrenic Patients J Canive and J Lauriello P.I. Otsuka America Pharmaceutica 1996 Study RIS-USA-72 Safety and Efficacy of Risperidone 8mg QD and 4mg QD Compared to Placebo in the treatment of Schizophrenia J. Lauriello Janssen Pharmaceutica 1995-1996 Studies Ziprasidone (CP-88,059) Protocols 128-108 and 128-114 Double Blind and Open Label Studies of the antipsychotic Ziprasidone A. Reeve P.I. , L. Hammond P.I. J Lauriello sub P.I. Pfizer Inc. 1994-1996 Studies BPI 1201 and BP 1201X Double Blind and Open Label Studies of the Antipsychotic Zotepine A. Reeve P.I. J. Lauriello sub P.I. Boots Pharmaceuticals, Inc 1994-1996 Study M-098 Double Blind Study of Atypical Antipsychotic Sertindole versus placebo and haloperidol 1993-1994. J. Lauriello P.I. Palo Alto VAMC Abbott Pharmaceuticals, Inc.
Service Grants City of Albuquerque Assertive Community Treatment Program Physician Service Grant John Lauriello P.I. 2005-2006 State of New Mexico Antipsychotic Algorithm Project Consultation Grant--- New Mexico Department of Health J. Lauriello and Juan Bustillo P.I.1999-2000 Updated 9/05/06 |