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C O R E M E M B E R S
& E X P E R T I S E
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Larry Sklar, PhD – Core
Leader
Chairperson, Professor
1 University of New Mexico
Department of Pathology
MSC08-4640
Albuquerque,
NM 87131
Phone: (505)272-6892
Fax: (505)272-6995
lsklar@salud.unm.edu
Dr. Sklar is Regents Professor of
Pathology and Director of Research Programs and Biotechnology in the
Cancer Center. He has more than 180 publications and patents in the
areas of leukocyte biology, molecular assembly in signal transduction
and cell adhesion, and technology for molecular assembly and drug
discovery. Sklar is presently funded as PI to develop technological
interfaces between signal transduction and drug discovery (NIH BECON
GM60799) and molecular assemblies in cell adhesion (NIH RR14175). He is
Co-PI of a second NIH BECON project with Novasite, Inc. (San Diego, Ca.)
in high throughput screening for drug discovery using molecular
evolution tools (AI48517). He is PI and Director of the UNM Proteomics
shared facilities (NCI R24 CA8839) and is responsible for integrating
the activities in mass spec, protein separation, flow cytometry, and
microscopy.
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Bruce Edwards, PhD -
Flow Cytometry Sub Core Leader
Associate Professor
1 University of New Mexico
Dept. of Pathology
MSC08-4640
Albuquerque,
NM 87131
Phone: (505) 272-6206
bedwards@salud.unm.edu
Dr. Edwards is
a Research Associate Professor
of Pathology and the flow cytometry Director. He was hired in part with
funding from the NIH IDeA grant and works collaboratively within the
facility in experimental design and performance for UNM investigators.
His research interests are in signal transduction, cell activation and
cell adhesion in leukocytes. He
has more than 40 publications describing his research, most involving
novel applications in flow cytometry technology.
He and Sklar have developed hardware for a variety of novel
sampling handling procedures to enable flow cytometric analysis of
non-pressurized cell samples such as adhesive interactions from a cone
and plate viscometer and high throughput from multi-well plates.
Edwards is presently funded as
Co-PI in a bioengineering consortium to
develop
novel high throughput flow cytometry technology for drug discovery (NIH
BECON GM60799).
Dr.
Edwards will be responsible for daily oversight and scheduling of
cytometry operations. He is responsible for the daily oversight of Mark
Curry for molecular assembly and screening applications Mark Curry is
the technical staff member responsible for all routine flow cytometry
maintenance and applications. He has more than 10 years experience in
cell biology and flow cytometry. He has recently received training on
the Cytomation MoFlo High Speed Cell Sorter.
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Tom Williams, PhD -
DNA Sequencing/Synthesis and QRT-PCR SubCore Leader-
Professor
1 University of New Mexico
Dept. of Pathology
MSC08-4640
Albuquerque,
NM 87131
Phone: (505)272-8059
twilliams@salud.unm.edu
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Charlotte Mobarak, PhD
Post-Doctoral Fellow
1 University of New Mexico
Department of Biochemistry & Micro Biology
MSC08-4670
Albuquerque,
NM 87131
Phone: (505) 272-8193
cmobarak@salud.unm.edu
2D
Gel –
Charlotte
Mobarak, PhD, is experienced in all phases of 2-D gel analysis and will
be able to direct the flow of samples from gel sample preparation to
identification by MALDI-MS or LC-MS-MS.
She has extensive experience in running and analyzing 2-D gels
.Her training includes a special course in 2-D gel technology at the
Bio-Rad facility in Hercules, California, a MALDI-MS and Voyager
software course at the Applied Biosystems Training center in Foster
City, California and advanced personalized training in MALDI-MS.
MALDI
The Voyager Elite MALDI-TOF
instrument is a refurbished and upgraded instrument capable of high
resolution and mass accuracy for protein identification.
If MALDI-MS proves unable to identify a sample, the Micromass Q-TOFTm
electrospray LC-MS-MS provides mass accuracy of 5ppm for peptides and
can generate peptide sequences de novo from MS-MS spectra with high
confidence levels.
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Scott Ness, PhD -
Genomics Sub Core Leader
Assistant Professor
1 University of New Mexico
Department of Molecular Genetics and Micro Biology
MSC08-4660
Albuquerque,
NM 87131
Phone: (505) 272-9883
sness@salud.unm.edu
Dr. Ness is a molecular cell biologist
funded by NCI for studies of the role of the transcription factor, c-Myb,
in cell cycle control, differentiation and tumorigenesis. He is a member
of the Department of Molecular Genetics and Microbiology and
the Cancer Research and Treatment Center. He has over 20 years of experience in protein biochemistry and molecular
biology during which he has constructed or supervised the construction
of over 200 expression vectors that were subsequently used for the
successful production of cancer-relevant proteins in vitro or in
bacteria, yeast, insect cells or animal cells.
Dr. Ness has developed a wide variety of expression vectors
including GST-fusion proteins and other bacterial expression vectors,
yeast two-hybrid systems, avian and mammalian retroviruses, baculovirus
vectors for insect cells and mammalian expression and reporter systems.
The technical staff include Gavin Pickett, Ph.D., the
Technical Director, and Marilee Morgan, M.S., a Senior Research
Assistant.
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