Associate Professor
Specialty: Medicinal Chemistry & Toxicology
Division of Pharmaceutical
Sciences
Office: Research Incubator Building, room 293
Phone: 505.272.4103
Dr. Timmins's research is generally based upon studying the mechanisms and roles of free radical formation and damage in biological systems. We combine advanced EPR techniques for directly studying the important free radical intermediates with conventional measures of cell damage and altered physiology. By a detailed understanding of these processes, we hope to rationally design new therapies. Systems that are currently under study are:
1. How melanin acts as photosensitizer in melanoma formation, and how can this be inhibited to protect against melanoma ?
2. What radicals are formed by KatG activation of isoniazid, how do they react, and how can we use this to rationally improve anti-TB activity ?
3. Can we rationally improve TB diagnostic and Vaccine technologies ?
We also collaborate extensively with several groups: at UNM these include C. Jeff Brinker, Vojo Deretic, Hattie Gresham and Jim Liu.
University of Leeds, UK, BSc Biochemistry, 1986
University of Leeds, UK, PhD Biochemistry 1990
Lund, L. P. & Timmins, G. S. Melanoma, long wavelength ultraviolet and sunscreens: controversies and potential resolutions. Pharmacol Ther 114, 198-207 (2007).
Timmins, G. S. & Deretic, V. Mechanisms of action of isoniazid. Mol Microbiol 62, 1220-7 (2006).
Wood, S. R. et al. UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production. Proc Natl Acad Sci U S A 103, 4111-5 (2006).
Wood, S. R. et al. Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosa. Free Radic Res 41, 208-15(2007)
The
University of New Mexico’s Doctor of Pharmacy program is
accredited by the Accreditation Council for Pharmacy Education,
20 North Clark Street, Suite 2500, Chicago, IL 60602-5109, TEL
(312) 664-3575 , FAX (312) 664-4652,
URL
http://www.acpe-accredit.org/
05/05/2008 09:19:14 AM -0600.