Regents Professor
Specialty: Pharmacology & Toxicology
Division of Pharmaceutical
Sciences
Office: Research Incubator Building, room 225
Phone: 505.272.2482
The research in my laboratory centers on receptor-mediated signal transduction, with an emphasis on changes in cellular function arising from certain receptor signaling pathways during tumorigenesis and tumor progression. In particular, we focus on receptor tyrosine kinases such as the epidermal growth factor (EGF) receptor. EGF receptor activation can regulate cellular events involved in invasive behavior including modulation of cellular attachments, proteolysis of extracellular matrix and migration. We are working to identify functional endpoints that are a direct consequence of elevated EGF receptor expression to further our understanding of the significance of EGF receptor overexpression in epithelial tumors. Additionally, we are investigating the impact of a naturally occurring mutant of the EGF receptor that arises in many human tumors. Our interests in toxicology address regulation of signal transduction pathways by environmental stimuli such as ultraviolet radiation and arsenic that are known to play a role in skin carcinogenesis.
Links
McCawley, L.J., Li, S., Benavidez, M., Halblieb, J., Wattenberg, E.V. and Hudson, L.G. (2000) Elevation of intracellular cyclic adenosine 3',5'-monophosphate inhibits growth factor mediated matrix metalloproteinase (MMP)-9 induction and keratinocyte migration. Mol. Pharmacol. 58:145-151.
Davis, J.W., Lauer, F.T., Burdick, A.D., Hudson, L.G., Denison, M.S. and Burchiel, S.W. (2000) Growth regulation by AhR ligands in the human mammary epithelial cell line MCF-10A. Organohalogen Compounds 49:13-16.
Gaudry, C.A., Palka, H.L., Dusek, R.L., Huen, A.C., Khandekar, M.J., Hudson, L.G. and Green, K.G. (2001) EGF Dependent Tyrosine Phosphorylated Plakoglobin is Associated with Desmogleins but not Desmoplakin. J. Biol. Chem. 276:24871-24880.
Burdick, A.D., Davis, J.W., Liu, K.J., Hudson, L.G., Shi, H., Monske, M.L. and Burchiel, S.B. (2003) Benzo[a]pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in MCF-10A cells. Cancer Research 63: 7825-7833
Shi, H., Hudson, L.G., Liu, K.J. (2004) Oxidative stress and apoptosis in metal ion induced carcinogenesis", Free Radical Biol. Med., 37:582-93.
Shi H, Hudson L.G., Ding W, Wang S, Cooper KL, Liu S, Chen Y, Shi X, Liu KJ. (2004) Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals. Chem Res Toxicol. 17:871-8.
Cooper, K.L., Myers, T.A., Rosenberg, M., Chavez, M., and Hudson, L.G. (2004) Roles of Mitogen Activated Protein Kinases and EGF receptor in Arsenite-stimulated Matrix Metalloproteinase-9 Production. Toxicology and Applied Pharmacology 200:177-85.
Savagner, P, Kusewitt, DF, Gridley, T, Magnino, F, Carver, EA, Hudson, L.G. (2005) The Developmental Transcription Factor Slug Participates in Reepithelialization During Cutaneous Wound Healing. J. Cellular Physiology 202:858-66.
Symowicz, J., Adley, B.L., Woo, M.M.M., Auersperg, N., Hudson, L.G., Stack, M.S. Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. (Cancer Research, 65:2234-2242).
Choi, C., Savanger, P., Hudson, L.G. , Kusewitt, D.F. (2005) An in situ hybridization technique to detect low-abundance Slug mRNA in adherent cultured cells. In: In Situ Hybridization Protocols 3rd Edition, ed. Darby I, Hewitson TD, Humana Press, Totowa, 2005.
Arnoux V., Côme C., Hudson, L.G., Kusewitt D., and Savagner P. Cutaneous wound reepithelialization: a partial and reversible EMT. . In: Rise and Fall of Epithelial Phenotype: Concepts of Epithelial-Mesenchymal Transition, ed. Savagner P, Springer, Berlin, pp. 111-134, 2005.
Ding, W., Hudson, L.G., Liu, K.J. Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes Mol Cell Biochem. 2005 279(1-2):105-12.
Ning Y, Zeineldin R, Liu Y, Rosenberg M, Stack MS, and Hudson, L.G. Down-regulation of integrin ?2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell Spreading and focal adhesion formation. Cancer Research 2005, 65(20):9280-9286.
Zeineldin R, and Hudson LG. Epithelial cell migration in response to epidermal growth factor. In: Patel TB, and Bertics PJ, editors. Epidermal growth factor, methods and protocols. Methods in Molecular Biology, 2005, v.327, p.147-158. Humana Press, Totowa, NJ.
Zeineldin, R., Rosenberg, M., Ortega, D., Chavez, M.G., Stack, M.S., Kusewitt, D.F., Hudson, L.G. (2006) Mesenchymal transformation in epithelial ovarian tumor cells expressing epidermal growth factor receptor variant III. Molec. Carcinogenesis 2006 Jun 20; [Epub ahead of print]
Hudson, L.G., Choi, C., Newkirk, K.M., Parkhani, J., Cooper, K.L., Lu, P., Kusewitt, D.F. (2006) Ultraviolet radiation stimulates expression of Snail family transcription factors in keratinocytes. Molec. Carcinogenesis (in press)
The
University of New Mexico’s Doctor of Pharmacy program is
accredited by the Accreditation Council for Pharmacy Education,
20 North Clark Street, Suite 2500, Chicago, IL 60602-5109, TEL
(312) 664-3575 , FAX (312) 664-4652,
URL
http://www.acpe-accredit.org/
05/05/2008 09:19:08 AM -0600.