Faculty Homepages

 

 

Matthew James Campen, PhD, MSPH

Associate Professor
Department of Pharmaceutical Sciences
Office: Nursing/Pharmacy Building, room B82
Phone: 505.925.7778

Email
CV

Dr. Campen's Laboratory

 

Our lab is broadly interested in the cross-talk of the cardiovascular and respiratory system in health and disease. Our primary research focus involves the impact of inhaled toxicants, especially common air pollutants, on vascular function and injury. We work closely with colleagues at the Lovelace Respiratory Research Institute to examine the relative vascular impact of specific components of complex pollutant mixtures, such as emissions from vehicular engines. We have identified roles for monoxide gases (link to campen et al., EHP 2010) in activating vascular metalloproteinase activity and particulate matter in promoting inflammation in vascular lesions (link to Campen et al., TAAP 2010). Research into the basic pathways underlying the biological responses to engine emissions have uncovered roles for endothelin receptors, NOS, and vascular oxidative stress (link to Lund et al, ATVB 2009 and Cherng et al AJP 2009, EHP 2010). In collaboration with LRRI and the University of Washington, we have recently been awarded a major EPA Air Quality Research Center grant, the focus of which will be to further pursue the biological mechanisms, examining roles for adaptive immunity in driving the extrapulmonary toxicity of inhaled pollutants, as well as studying the impact of physical and photochemical aging on the toxicity of complex source emissions.


Vascular Zymography

 

 

 

 

 

 

 

 

 

 

 

 

 

 

We also are interested in the basic biological role of the ubiquitin proteasome pathway in regulating vascular remodeling. We have recently identified that ubiquitin ligases responsible for skeletal muscle atrophy may also have a key role in regulating smooth muscle cell growth and differentiation. In models of experimental vascular hypertrophy, as is a common outcome in pulmonary hypertension and atherosclerosis, we observe a downregulation of these ubiquitin ligases (atrogin-1 and MuRF-1) that is proportional to the severity of remodeling in the vasculature. Ongoing studies are attempting to modulate these pathways by direct and indirect means to reverse pathological growth of smooth muscle.

 

 

Atrogin Pathway

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Lab Group Members

 

Mario Aragon, BS
Graduate Student

Molly Harmon, BS
Doctoral Candidate 

Selita Lucas
Research Specialist

Sarah Robertson, PhD
Post Doctoral Fellow

 

Extra links

 

UNM HSC Signature Program in Cardiovascular and Metabolic Disease

UNM HSC Environmental Health Signature Program

Environmental Protection Agency

National Institute for Environmental Health Sciences

Society of Toxicology (SOT)

SOT Cardiovascular Toxicology Specialty Section

Mountain West Society of Toxicology

Mountain West SOT Annual Meeting in Tucson, Sept 9-10, 2010:

UNM College of Pharmacy Dean Search

UNM College of Pharmacy Radiopharmaceutical Sciences

UNM Health Sciences Center Vascular Physiology Group

 

Journals

 

Toxicological Sciences

Cardiovascular toxicology

Inhalation toxicology

 

The University of New Mexico’s Doctor of Pharmacy program is accredited by the Accreditation Council for Pharmacy Education, 20 North Clark Street, Suite 2500, Chicago, IL 60602-5109, TEL (312) 664-3575 , FAX (312) 664-4652, URL http://www.acpe-accredit.org/

06/13/2013 10:04:10 AM -0600.