Education and Honors

• University of California at Davis; B.S. in Biochemistry, 1973
• University of California at SanFrancisco SOM, Ph.D. in Pharmacology, 1977
• Postdoctoral Fellow, National Cancer Institute NRSA, UNM SOM Immunobiology Lab, 1977-78
• Chancellor's Research Fellowship - U.C. Davis, l974
• Graduate Student Assoc. Research Award-U.C. San Francisco, 1977
• Rho Chi Pharmaceutical Honor Society, 1986
• UNM Presidential Lectureship, 1986-88
• Visiting Scientist at the Sandoz Research Institute (Basel, SWITZERLAND), summer, 1987
• College of Pharmacy Teacher of the Year, 1991-92 , 1993-94

Research Interests

My research interests are generally in the area of immunopharmacology and immunotoxicology with emphasis on the effects of drugs and environmental agents on signaling pathways controlling lymphocyte activation and apoptosis. We have recently expanded this interest to include control of normal human mammary cell proliferation and proto-oncogene activation by environmental agents. We also have extensive experience in preclinical and clinical evaluation of new biotechnology drugs, most notably cytokines, growth factors, adhesion molecules, and monoclonal antibodies.

Instructional Activities

PHARM 480/580 -- Lectures in blood toxicology, immunotoxicology, and carcinogenesis

PHARM 714 -- Immunology and Biotechnology - introduction to cell and molecular immunology, immunopharmacology, immunochemistry, adjuvants, immunosuppressants, drug allergic reactions, biotechnology products; clinical immunology and immunologic diseases; immunodeficiency, autoimmunity, vaccines, HIV and therapeutics

PHARM 731/732 -- Autacoids, anti-histamines, NSAIDs, cytokines, hematopoietic agents: cytokines and growth factors; anti-coagulants: heparin and oral agents; thrombolytics

PHARM 586 -- Toxicology research conference

PHARM 593 -- Toxicology Seminar

PHARM 598 -- Advanced Topics on cell signaling, apoptosis, immunotoxicology and cancer

Selected Publications

Burchiel, SW, and Luster, MI (2001) Signaling by environmental polycyclic aromatic hydrocarbons in human lymphocytes. Clin Immunol 98, 2-10.

Burchiel, SW, Knall, CM, Davis, JW II, Paules, RS, Boggs, SE, Afshari, CA (2001) Analysis of Genetic and Epigenetic Mechanisms of Toxicity: Potential Roles of Toxicogenomics and Proteomics in Toxicology. Toxicol Sci 59, 193-195.

Pessah, IN, Beltzner, C, Burchiel, SW, Sridhar, G, Penning, T, and Feng, W. (2001) A bioactive metabolite of benzo(a)pyrene, benzo(a)pyrene-7,8-dione, selectively alters microsomal Ca2+ transport and ryanodine receptor function. Molec Pharmacol 59, 506-513.

Davis, JW, Lauer, FT, Burdick, AD, Hudson, LG, and Burchiel, SW. (2001) Prevention of apoptosis by TCDD in the MCF-10A cell line: Correlation with increased TGF production. Cancer Research 61, 3314-3320.

Harris, MN, Burchiel, SW, Winyard, PG, Engen, JR, Mobarak, CD, and Timmins, GS. (2002) Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry, Chem Res Toxicol 15, 1589-1594.

Nichols, WK, Mehta, R, Skordos, K, Mace, K, Pfeifer, AM, Carr, B, Burchiel, SW, and Yost, GS. (2003) 3-Methylindole toxicity to human bronchial epithelial cell lines. Toxicol Sciences 71, 229-236.

Andersen, ME, Benson, JM, Burchiel, SW, Dixit, R, Feldman, RG, Kacew, S, Kerkvliet, NI, Sandy, MS, and Valentine, WM (2003) Toxicologic Assessment of Jet-Propulsion Fuel 8, National Research Council, The National Academies Press, Washington.

Davis, JW II, Burdick, AD, Lauer, FT, Lane, JL, and Burchiel, SW. (2003) The Aryl hydrocarbon receptor (AhR) Antagonist, 3' Methoxy-4' Nitro-Flavone (MNF), Attenuates TCDD-Dependent Regulation of Growth Factor Signaling and Apoptosis in the MCF-10A Cell Line. Toxicol Appl Pharmacol 188, 42-49.

Kepley, CL, Lauer, FT, Oliver, JO, and Burchiel, SW. (2003) Polycyclic aromatic hydrocarbons (PAHs) enhance IgE-mediated histamine release and IL-4 production in human basophils. Clin Immunol 107, 100-109.

Reed, MD, Monske, M, Lauer, FT, Meserole, SP, Born, JL, and Burchiel, SW. (2003) Benzo(a)pyrene diones are produced by photochemical an enzymatic oxidation and induce concentration-dependent decreases in the proliferative state of human pulmonary epithelial cells. J Toxicol Environ Health 66, 1189-1205.

Arrieta, DE, Ontiveros, CC, Li, W-W, Garcia, JH, Denison, MS, McDonald, JD, Burchiel, SW and Washburn, BS. (2003) Aryl Hydrocarbon Receptor-Mediated Activity of Particulate Organic Matter from the Paso del Norte Airshed Along the U.S.-Mexico Border, Environ Health Perspectives 111, 1299-1305.

Burdick, AD, Davis, JD, Liu, KJ, Hudson, LG, Shi, H, Monske, ML, and Burchiel, SW. (2003) Benzo(a)pyrene Quinones Increase Cell Proliferation, Generate Reactive Oxygen Species, and Transactivate the Epidermal Growth Factor Receptor, Cancer Research 63, 7825-7833.

Burchiel, SW, Lauer, FT, McDonald, JD, and Reed, M (2004) Systemic Immunotoxicity in AJ Mice Following Six Month Whole Body Inhalation Exposure to Diesel Exhaust, Toxicol Appl Pharmacol, in press.