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Scott W. Burchiel, PhD

Associate Dean for Research

Professor and DeSantis Endowed Chair of Pharmacogenomics

 

Director, UNM HSC Environmental Health Signature Program

Director, New Mexico Center for Isotopes in Medicine

Specialty: Immunopharmacology & Immunotoxicology

Department of Pharmaceutical Sciences
Room B-80 Nursing Pharmacy Bldg (NRPH)

Phone: 505.272.0920

Fax: 505.272.6749

Email

 

Education and Honors

  • University of California at Davis; B.S. in Biochemistry, 1973

  • University of California at San Francisco SOM, Ph.D. in Pharmacology, 1977

  • Postdoctoral Fellow, National Cancer Institute NRSA, UNM SOM Immunobiology Lab, 1977-78

  • Chancellor's Research Fellowship - U.C. Davis, l974

  • Graduate Student Assoc. Research Award-U.C. San Francisco, 1977

  • Rho Chi Pharmaceutical Honor Society, 1986

  • UNM Presidential Lectureship, 1986-88

  • Visiting Scientist at the Sandoz Research Institute (Basel, SWITZERLAND), summer, 1987

  • College of Pharmacy Teacher of the Year, 1991-92, 1993-94

  • DeSantis Endowed Chair of Pharmacogenomics (2007)

Research Interests

My research interests are generally in the area of immunopharmacology and immunotoxicology with emphasis on the effects of drugs and environmental agents (particularly polycyclic aromatic hydrocarbons, PAHS) on signaling pathways controlling lymphocyte activation and apoptosis. We also have research projects studying human breast cancer where we examine the control of normal human mammary cell proliferation and proto-oncogene activation by environmental agents and ethanol. Our lab has been investigating the role of PAHs and airborne particulates in asthma and collaborates on a U.S. Mexico Border Health project with the University of Texas at El Paso. We utilize genomics and epigenetics techniques in our research. We have extensive experience in preclinical and clinical evaluation of new biotechnology drugs, most notably cytokines, growth factors, adhesion molecules, and monoclonal antibodies.

Instructional Activities

  • PHARM 581 – Graduate Toxicology (IOR)

  • PHARM 593 -- Toxicology Seminar

  • PHARM 598 – Research Topics

  • PHARM 599/699 – Thesis and Dissertation

  • PHARM 706 – Foundations (lectures in Enzymology and Cell Signaling)

  • PHARM 732 – Immunomodulators and Immunosuppressants

Selected and Complete Last 3 Year’s Publications  (from >107 refereed articles and book chapters)

  1. Gao, J, Lauer, FT, Dunaway, S, and Burchiel, SW (2005) Cytochrome P450 1B1 is required for 7,12-dimethylbenz(a)anthracene (DMBA) induced spleen cell immunotoxicity. Toxicol Sci,. 86, 68-74.

  2. Rubin, RL, Hermanson, TM, Bedrick, EJ, McDonald, JD, Burchiel, SW, Reed, MD, Sibbitt, WL Jr. (2005) Effect of Cigarette Smoke on Autoimmunity in Murine and Human Systemic Lupus Erythematosus. Toxicol Sci. 87, 86-96

  3. Gao, J, Voss, A,  Pessah, IN, Lauer, FT, Penning, TM, and Burchiel, SW (2005) Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicol Sci. 87, 419-426.

  4. Andrew D. Burdick, AD, Ivnitski-Steele, I, Lauer, FT, and Burchiel, SW. (2006) Pyk2 mediates anti-apoptotic  Akt signaling in response to benzo[a]pyrene diol epoxide (BPDE) in mammary epithelial cells, Carcinogenesis 27, 2331-2340.

  5. Burns-Naas, L-A, Kerkvliet, NI, Laskin, DL, Bortner, CD, and Burchiel, SW (2007). The Use of Multiparameter Flow Cytometry in Immunotoxicology and Immunopharmacology, In: Immunotoxicology and Immunopharmacology, 3rd Edition (Eds: R. Luebke, R. House, and I. Kimber), Taylor and Francis, New York, pp.97-122,

  6. Burchiel SW, Thompson TA, Lauer FT, Oprea TI. (2007) Activation of dioxin response element (DRE)-associated genes by benzo(a)pyrene 3,6-quinone and benzo(a)pyrene 1,6-quinone in MCF-10A human mammary epithelial cells. Toxicol Appl Pharmacol. 221, 203-214.

  7. Gao J, Lauer FT, Mitchell LA, Burchiel SW. (2007) Microsomal Expoxide Hydrolase is Required for 7,12-Dimethylbenz[a]anthracene (DMBA) Induced Immunotoxicity in Mice. Toxicol Sci. 98, 137-144.

  8. Mitchell LA, Gao J, Wal RV, Gigliotti A, Burchiel SW, McDonald JD. (2007) Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci.100, 203-214.

  9. Gao J, Mitchell LA, Lauer FT, Burchiel SW. (2008) P53 and ATM/ATR Regulate 7,12-Dimethylbanz(a)anthracene (DMBA) Induced Immunosuppression. Mol Pharmacol. 73, 137-146.

  10. Rodriguez-Fragoso L, Reyes-Esparza J, Burchiel SW, Herrera-Ruiz D, Torres E. (2008) Risks and benefits of commonly used herbal medicines in Mexico. Toxicol Appl Pharmacol. 227, 125-135.

  11. Dennis, MK, Bowles, H, MacKenzie, DA, Burchiel, SW, Edwards, BS, Sklar, LA, Prossnitz, ER, and Thompson, TA (2008). A Multifunctional Androgen Receptor Screening (MARS) Assay Using the High-Throughput HyperCyt® Flow Cytometry System, Cytometry 73, 390-399.

  12. Rodríguez-Fragoso L, Melendez K, Hudson LG, Lauer FT, Burchiel SW. (2009) EGF-receptor phosphorylation and downstream signaling are activated by benzo[a]pyrene 3,6-quinone and benzo[a]pyrene 1,6-quinone in human mammary epithelial cells. Toxicol Appl Pharmacol. 235, 321-328.

  13. Lauer, FT, Mitchell, LA, Bedrick, E, McDonald, JD, Lee, W-Y, Li, W-W, Olvera, H, Amaya, MA, Berwick, M, Gonzales, M, Currey, R, Pingitore, NE Jr, and Burchiel, SW. (2009) Temporal-Spatial Analysis of U.S.-Mexico Border Environmental Fine and Coarse PM Air Sample Extract Activity  in Human Bronchial Epithelial Cells, Toxicol Appl Pharmacol, 238, 1-10.

  14. Mitchell, LA, Lauer, FT, Burchiel SW, and McDonald, JD. (2009) Mechanisms of Inhaled Multiwalled Carbon Nanotube-Induced Systemic Immune Suppression in Mice, Nature Nanotechnol, 4, 451-456.

  15. Burchiel, SW, Mitchell, LA,  Lauer, FT, Sun, X, McDonald, JD, Hudson, LG, and Liu,  KJ. (2009) Immunotoxicity and Bisodistribution Analysis of Arsenic Trioxide in C57Bl/6 Mice Following a Two-Week Inhalation Exposure, Toxicol Appl Pharmacol, 241,  253–259.

 

 

 

The University of New Mexico’s Doctor of Pharmacy program is accredited by the Accreditation Council for Pharmacy Education, 135 LaSalle Street, Suite 4100, Chicago, IL 60603-4810, TEL (312) 664-3575 , FAX (312) 664-4652, URL http://www.acpe-accredit.org/

08/25/2011 09:55:50 AM -0600.