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Mailing address:
UNM College of Pharmacy
Dept. of Pharmaceutical Sciences
MSC09 5360
1 UNM
Albuquerque NM 87131-0001

Physical address:
2705 Frontier NE, suite 208

Phone: 505.272.3660

 

 

Faculty Homepages

 

Yubin Miao, PhD

Assistant Professor

Specialty: Radiopharmaceutical Sciences

Department of Pharmaceutical Sciences
Office: College of Pharmacy, Room B64E
Phone: 505.925.4437

Email

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Click here for an opportunity to work in my laboratory!

 

Research Interests

The research interests in my laboratory are focused on developing novel radiolabeled peptides for cancer (melanoma, breast and prostate cancers) diagnosis and treatment. Specifically, we are using radiolabeled peptides to target G protein-coupled receptors (GPCRs) over-expressed on cancer cells for cancer detection and therapy. Radiolabeled peptides are attractive probes for cancer imaging and therapy due to their specific nanomolar binding affinities with the GPCRs over-expressed on cancer cells. Radiolabeled peptides can selectively deliver diagnostic and therapeutic radionuclides to cancer cells through peptide-receptor interaction for imaging and therapy. Hence, malignant tumors can be detected non-invasively by imaging modalities (SPECT or PET) through the collection of signals generated from diagnostic radionuclides. Moreover, malignant tumors can be effectively treated by targeted radiation yielded from therapeutic radionuclides delivered by the peptides selectively. 

 

67Ga-DOTA-Cyc19%20flank%20Max 67Ga-DOTA-Cyc19 mets Max
 

Primary (left) and pulmonary metastatic (right) melanoma imaging

(Haixun Guo, et al. Bioconjugate Chemistry 2009;20:2356-2363)

 Education
  • Beijing Normal University, P. R. China, B.S. in Chemistry, 1992
  • Beijing Normal University, P. R. China, Ph.D. in Radiopharmaceutical Chemistry, 1997

Honors

  • Outstanding Ph.D. Candidate Award, Beijing Normal University, 1996
  • Postdoctoral Fellowship of Life Science Mission Enhancement, University of Missouri-Columbia, 1999-2001
  • Beijing Normal University Outstanding Research Achievement Award, 2002
  • American Society of Nuclear Medicine Radiopharmaceutical Science Young Investigators Award, 2002
  • American Association of Colleges of Pharmacy New Investigator Award, 2007
  • Department of Defense Breast Cancer Research Program Idea Award, 2008

Instruction

Dr. Miao teaches in the following courses:

  • Pharm 701

  • Pharm 702

  • Pharm 710

  • Pharm 732

Selected Publications

Yubin Miao, Nellie K. Owen, Timothy J. Hoffman, Thomas P. Quinn. Therapeutic efficacy of a 188Re labeled ?-melanocyte stimulating hormone peptide analog in murine and human melanoma-bearing mouse models. Journal of Nuclear Medicine 2005;46:121-129.

Yubin Miao, Timothy J. Hoffman, Thomas P. Quinn. Tumor targeting properties of 90Y and 177Lu labeled alpha-melanocyte stimulating hormone peptide analogues in a murine melanoma model. Nuclear Medicine and Biology 2005;32:485-493.

Paul McQuade, Yubin Miao, Jeongsoo Yoo, Thomas P. Quinn, Michael J. Welch, Jason S. Lewis. Imaging of melanoma using 64Cu and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of a-MSH. Journal of Medicinal Chemistry 2005;48:2985-2992.

Yubin Miao, Mark Hylarides, Darrell R. Fisher, Herbert Moore, Dennis W. Wester, Alan R. Fritzberg, Richard Testa, Timothy J. Hoffman, Thomas P. Quinn. Melanoma therapy via peptide-targeted a-radiation. Clinical Cancer Research 2005;11:5616-5621.

Yubin Miao, Darrell R. Fisher, Thomas P. Quinn. Reducing renal uptake of 90Y and 177Lu labeled alpha-melanocyte stimulating hormone peptide analogues. Nuclear Medicine and Biology 2006;33:723-733.

Lihui Wei, Clayton Butcher, Yubin Miao, Fabio Gallazzi, Thomas P. Quinn, Michael J. Welch, Jason S. Lewis. Synthesis and Biological Evaluation of Cu-64 labeled Rhenium-Cyclized a-MSH Peptide Analog Using a Cross-Bridged Cyclam Chelator. Journal of Nuclear Medicine 2007;48:64-72.

Yubin Miao, Katherine Benwell, Thomas P. Quinn. 99mTc and 111In labeled alpha-melanocyte stimulating hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection. Journal of Nuclear Medicine 2007;48:73-80.

Jessica R. Newton, Yubin Miao, Susan L. Deutscher, Thomas P. Quinn. Melanoma imaging with pre-targeted bivalent bacteriophage. Journal of Nuclear Medicine 2007:48:429-436.

Yubin Miao, Thomas P. Quinn. Alpha-melanocyte stimulating hormona peptide-targeted melanoma imaging. Frontiers in Bioscience 2007;12:4514-4524.

Yubin Miao, Tiffani Shelton, Thomas P. Quinn. Therapeutic efficacy of a 177Lu labeled DOTA conjugated a-melanocyte stimulating hormone peptide in a murine melanoma-bearing mouse model. Cancer Biotherapy & Radiopharmaceuticals 2007;22:333-341.

Lihui Wei, Yubin Miao, Fabio Gallazzi, Thomas P. Quinn, Michael J. Welch, Amy L. Vavere, Jason S. Lewis. Ga-68 labeled DOTA-rhenium cyclized a-MSH Analog for imaging of malignant melanoma. Nuclear Medicine and Biology 2007;34:945-953.

Yubin Miao, Fabio Gallazzi, Haixun Guo, Thomas P. Quinn. 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide analogues for melanoma imaging. Bioconjugate Chemistry 2008;19:539-547.

Yubin Miao, Said D. Figueroa, Darrell R. Fisher, Herbert A. Moore, Richard F. Testa, Timothy J. Hoffman, Thomas P. Quinn. 203Pb-labeled alpha-melanocyte stimulating hormone peptide as an imaging probe for melanoma detection. Journal of Nuclear Medicine 2008;49:823-829.

Yubin Miao, Thomas P. Quinn. Peptide-targeted radionuclide therapy for melanoma. Critical Reviews in Oncology/Hematology 2008;67:213-228.

Haixun Guo, Nalini Shenoy, Benjamin M. Gershman, Jianquan Yang, Larry A. Sklar, Yubin Miao. Metastatic melanoma imaging with an 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Nuclear Medicine and Biology 2009;36:267-276.

Lihui Wei, Xiuli Zhang, Fabio Gallazzi, Yubin Miao, Xiaofang Jin, Martin W. Brechbiel, Heng Xu, Thomas Clifford, Michael J. Welch, Jason S. Lewis, Thomas P. Quinn. Melanoma imaging using 111In, 86Y and 68Ga labeled CHX-A”-Re(Arg11)CCMSH. Nuclear Medicine and Biology 2009;36:345-354.

Jianquan Yang, Haixun Guo, Fabio Gallazzi, R. Steven Padilla, Marianne Berwick, Yubin Miao. Evaluation of a novel RGD-conjugated alpha-melanocyte stimulating hormone hybrid peptide for potential melanoma therapy. Bioconjugate Chemistry 2009;20:1634-1642.

Haixun Guo, Jianquan Yang, Fabio Gallazzi, Eric R. Prossnitz, Larry A. Sklar, Yubin Miao. Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjugate Chemistry 2009;20:2162-2168.

Haixun Guo, Jianquan Yang, Nalini Shenoy, Yubin Miao. Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging. Bioconjugate Chemistry 2009;20:2356-2363.

Haixun Guo, Jianquan Yang, Fabio Gallazzi, Yubin Miao. Reduction of the Ring Size of Radiolabeled Lactam Bridge-Cyclized Alpha-MSH Peptide Resulting in Enhanced Melanoma Uptake. Journal of Nuclear Medicine 2010;51:418-426.

Thomas P. Quinn, Xiuli Zhang, Yubin Miao. Targeted Melanoma Imaging and Therapy with Radiolabeled Alpha-Melanocyte Stimulating Hormone Peptide Analogues. The Italian Journal of Dermatology 2010;145:245-258.

Jianquan Yang, Haixun Guo, Yubin Miao. Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nuclear Medicine and Biology 2010;37:873-883.

Jianquan Yang, Haixun Guo, R. Steven Padilla, Marianne Berwick, Yubin Miao. Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide. Bioorganic & Medicinal Chemistry 2010;18:6695-6700.

Haixun Guo, Jianquan Yang, Fabio Gallazzi, Yubin Miao. Effects of the amino acid linkers on melanoma-targeting and pharmacokinetic properties of indium-111-labeled lactam bridge-cyclized α-MSH peptides. Journal of Nuclear Medicine 2011;52:608-616.

Haixun Guo, Fabio Gallazzi, Larry A. Sklar, Yubin Miao. A novel Indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging. Bioorganic & Medicinal Chemistry Letters 2011;21:5183-5186.

Haixun Guo, Jie Lu, Helen Hathaway, Melanie E. Royce, Eric R. Prossnitz, Yubin Miao. Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjugate Chemistry 2011;22:1682-1689.

Jianquan Yang, Yubin Miao. Substitution of Gly with Ala enhanced the melanoma uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorganic & Medicinal Chemistry Letters 2012;22:1541-1545.

Jianquan Yang, Jie Lu, Yubin Miao. Structural modification on the Lys linker enhanced tumor to kidney uptake ratios of Tc-99m-labeled RGD-conjugated alpha-MSH hybrid peptides. Molecular Pharmaceutics 2012;9:1418-1424.

Haixun Guo, Fabio Gallazzi, Yubin Miao. Ga-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake. Bioconjugate Chemistry 2012;23:1341-1348.

Haixun Guo, Yubin Miao. Cu-64-labeled lactam bridge-cyclized alpha-MSH peptides for PET imaging of melanoma. Molecular Pharmaceutics 2012;9:2322-2330.

Haixun Guo, Fabio Gallazzi, Yubin Miao. Design and evaluation of Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptides for melanoma imaging. Molecular Pharmaceutics 2013;10:1400-1408.

Haixun Guo, Yubin Miao. Melanoma targeting property of a Lu-177-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorganic & Medicinal Chemistry Letters 2013;23:2319-2323.

Jianquan Yang, Liqin Liu, Yubin Miao. Effects of the Arg-Pro and Gly-Gly-Nle moieties on melanocortin-1 receptor binding affinities of alpha-melanocyte stimulating hormone peptides. ACS Medicinal Chemistry Letters 2013;4:1000-1004.

Haixun Guo, Helen J. Hathaway, Melanie E. Royce, Eric R. Prossnitz, Yubin Miao. The influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorganic & Medicinal Chemistry Letters 2013;23:5484-5487.

Adam M. Flook, Jianquan Yang, Yubin Miao. Evaluation of new Tc-99m-labeled Arg-X-Asp-conjugated alpha-melanocyte stimulating hormone peptides for melanoma imaging. Molecular Pharmaceutics 2013;10:3417-3424.

Jianquan Yang, Adam M. Flook, Changjian Feng, Yubin Miao. Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorganic & Medicinal Chemistry Letters 2014;24:195-198.

Kubra Durkan, Zongrun Jiang, Tammy L. Rold, Gary L. Sieckman, Timothy J. Hoffman Rajendra Prasad Bandari, Liqin Liu, Yubin Miao, Tamila Stott Reynolds, Charles J. Smith. A heterodimeric 64Cu-NO2A-RGD-Glu-6-Ahx-RM2 αvβ3/GRPr-targeting antagonist radiotracer for PET imaging of prostate cancer. Nuclear Medicine and Biology 2014;41:133-139.

Jie Lu, Helen J. Hathaway, Melanie E. Royce, Eric R. Prossnitz, Yubin Miao. Introduction of D-Phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorganic & Medicinal Chemistry Letters 2014;24:725-730.