Health Sciences Library & Informatics Center
MSC09 5100
1 University of New Mexico
Albuquerque, NM 87131-0001

Find Faculty at UNM Health Sciences Center

Angela Wandinger-Ness, PhD

Contact Information:
1 University of New Mexico
MSC 08 4640
Dept. Pathology
Albuquerque NM 87131-0001

505-272-1459
awandinger@salud.unm.edu

Department:
SOM Pathology Department

Education:
Post-doctoral Training : European Molecular Biology Lab , (1986-1991)
Ph.D. : University of California , (1985)
B.S. : University of Massachusetts , (1979)

Interests:

Research Interests

  • GTPases as targets of small molecules therapeutics for ovarian cancer and genetic diseases
  • Cellular & molecular basis of autosomal dominant polycystic kidney disease
  • Renal stem cells
  • Interrelationships between membrane trafficking, signaling cell polarity and disease pathology
  • Molecular mechanisms of Rab GTPases and lipid signaling in membrane trafficking



Education Interests:

  • Skill building and career development through cross-training in research and education
  • Development of training programs that build diversity in research and education


Publications:
* Herbert, B.-S., B.R. Grimes, W.M. Xu, M. Werner, C. Ward, S. Rossetti, P. Harris, E. Bello-Reuss, C. Miller, V. Gattone, C.L. Phillips, A. Wandinger-Ness and R. Bacallao. (2013) A Telomerase Immortalized Human Proximal Tubule Cell Line with a Truncation Mutation (Q4004X) in Polycystin-1. In Press, PLoS One.

* Chavez, M., C. Buhr, W. Petri, A. Wandinger-Ness, D. Kusewitt and L. Hudson. (2012) Differential Downregulation of E-cadherin and Desmoglein by Epidermal Growth Factor. Dermatology Research and Practice. 2012:309587. PMC3270554.

* Stein, M-P., M. Müller and A. Wandinger-Ness. (2012) Commandeering Rabs allows bacterial pathogens to establish intracellular niches. Invited review. Traffic: doi: 10.1111/tra.12000. [Epub ahead of print] Special Series on Pathogen-Host Cell Interactions. PMID: 22901006.

* Agola, J.O., L. Hong, Z. Surviladze, T. Buranda, O. Ursu, A. Waller, J.J. Strouse, D.S. Simpson, C.E. Schroeder, J.E. Golden, T.I. Oprea, J. Aubé, L.A. Sklar and A. Wandinger-Ness. (2012) A Competitive Nucleotide Binding Inhibitor: In vitro Characterization of Rab7 GTPase Inhibition. ACS Chemical Biology. 7:1095-108. NIHMSID 373989.

* BasuRay, S., S. Mukherjee, E. Romero, M.N.J. Seaman and A. Wandinger-Ness. (2013) Rab7 Mutants Associated with Charcot-Marie-Tooth Diesease Cause Delayed Growth Factor Receptor Transport and Altered Endosomal and Nuclear Signaling. J. Biol. Chem. [Epub ahead of print]

* Ward, H.H., E. Romero, A. Welford, R. Bacallao, V.H. Gattone II, A. Wandinger-Ness§ and T. Roitbak. (2011) Adult Human CD133/1+ Kidney Cells Isolated from Papilla Integrate into Developing Kidney Tubules. §Corresponding author. Biochimica et Biophysica Acta: Epub ahead of print PMID: 21255643

* Boucher, C.A.*, H.H. Ward*, R.L. Case, K.S. Thurston, X. Li, A. Needham, E. Romero, D. Hyink, S. Qamar, T. Roitbak, S. Powell, C. Ward, P.D. Wilson, A. Wandinger-Ness§ and R.N. Sandford. (2010) Receptor Protein Tyrosine Phosphatases are Novel Components of the Polycystin Complex. *Contributed equally. §Corresponding author. Biochimica et Biophysica Acta: epub ahead of print PMID: 21126580

* Oprea, T.I., J.E. Bauman, C.G. Bologa, T. Buranda, A. Chigaev, B.S. Edwards, J.W. Jarvik, H.D. Gresham, M.K. Haynes, B. Hjelle, R. Hromas, L. Hudson, D.A. Mackenzie, C.Y. Muller, J.C. Reed, P.C. Simons, Y. Smagley, J. Strouse, , Z. Surviladze, T. Thompson, O. Ursu, A. Waller, A. Wandinger-Ness, S.S. Winter, Y. Wu, S.M. Young, R.S. Larson, C. Willman, L.A. Sklar. (2011) Drug Repurposing from an Academic Perspective. Drug Discovery Today: Therapeutic Strategies. 8:61-69. PMC3285382; http://www.sciencedirect.com/science/article/pii/S1740677311000428

* Kher, R., E.C. Sha, M.R. Escobar, E.M. Andreoli, P. Wang, W.M. Xu, A. Wandinger-Ness, R. Bacallao. (2011) Ectopic Expression of Cadherin 8 is Sufficient to Cause Cyst Formation in a Novel 3D Collagen Matrix Renal Tubule Culture. American Journal of Physiology - Cell Physiology. 2011 Mar 9. Epub ahead of print PMID: 21389276

* Ward H.H., U. Brown-Glaberman, J. Wang, Y. Morita, S.L. Alper, E.J. Bedrick, V. Gattone II, D. Deretic and A. Wandinger-Ness. (2011) A Conserved Signal and GTPase Complex are Required for the Ciliary Transport of Polycystin-1. Mol. Biol. Cell. 22:3289-3305. PMC3172256.

* Agola, J.O., P. Jim, S. BasuRay, H.H. Ward and A. Wandinger-Ness. (2011) Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities. Clinical Genetics. Epub ahead of print doi: 10.1111/j.1399-0004.2011.01724.x

* Surviladze Z, A. Waller, Y. Wu, E. Romero, B.S. Edwards, A. Wandinger-Ness, and L.A. Sklar. (2010) Identification of a Small GTPase Inhibitor using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J. Biomolec. Screening. 15:10-20.

* BasuRay, S.*, S. Mukherjee*, E. Romero, M.C. Wilson and A. Wandinger-Ness. (2010) Rab7 Mutants Associated with Charcot-Marie Tooth Disease Exhibit Enhanced NGF-Stimulated Signaling. *Contributed equally. PLoS ONE: 5(12):e15351

* Surviladze Z, Waller A, Strouse JJ, Bologa C, Ursu O, Salas V, Parkinson JF, Phillips GK, Romero E, Wandinger-Ness A, Sklar LA, Schroeder C, Simpson D, Nöth J, Wang J, Golden J, Aubé J. (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US).