UNM HSC School of Medicine

Division of Biocomputing

Cytochrome P450s in Drug Metabolism and Disease

Tudor I. Oprea

Division of Biocomputing

Fall 2006

Lecture SlidesSupplementary materials

Part 1 (pdf)

Part 2 (pdf)

Part 3 (pdf)

Part 4 (pdf)

Fall 2005

These structures were downloaded from PDB, the Protein Data Bank,http://www.rcsb.org/pdb/

Cytochrome P450s - Featured Molecule of the Month on the Protein Data Bank website click here
1EUP Cytochrome P450 eryF from Saccharopolyspora erythraea, complexed with substrate Androstenedione
1PQ2 Cytochrome P450 2C8 from human, complexed with substrate Palmitic Acid
2BDM Cytochrome P450 2B4 from rabbit, complexed with inhibitor Bifonazole (antifungal)
2JOD Cytochrome P450 3A4 from human, complexed with substrate Erythromycin (antibiotic)
2F9Q Cytochrome P450 2D6 from human, substrate-free
1AKD Cytochrome P450cam from Pseudomonas putida, complexed with substrate 1s-camphor
1CPT Cytochrome P450-terp from Pseudomonas sp., substrate free
1DT6 Cytochrome P450 2c5 progesterone 21-hydroxylase from rabbit, substrate free
1EA1 Cytochrome P450 14 alpha-sterol demethylase (cyp51) from Mycobacterium tuberculosis, complexed with inhibitor fluconazole
1FAG Cytochrome P450 102, fatty acid hydroxylase from Bacillus Megaterium (BM3) complexed with substrate palmitoleic acid
1NOO Cytochrome P450cam from Pseudomonas putida, complexed with product 5-exo-hydroxycamphor
1NR6 Cytochrome P450 2c5, progesterone 21-hydroxylase from rabbit, complexed with diclofenac
1OG2 Cytochrome P450 2c9 from human (s-mephenytoin 4-hydroxylase), substrate free
1OG5 Cytochrome P450 2c9 from human (s-mephenytoin 4-hydroxylase), complexed with substrate s-warfarin
1OXA Cytochrome P450 eryf from Saccarapolyspora erythraea complexed with substrate, 6-deoxyerythronolide b
1PHF Cytochrome P450cam from Pseudomonas putida, complexed with inhibitor 4-phenyl imidazole
2CPP Cytochrome P450cam from Pseudomonas putida, complexed with substrate camphor
3CP4 Cytochrome P450cam from Pseudomonas putida, complexed with substrate adamantane
1TQN Cytochrome P450 3A4 from human (quinine 3-monooxygenase, nifedipine oxidase), substrate free, at 2.05 A resolution, residues 28-499
1W0E Cytochrome P450 3A4 from human (quinine 3-monooxygenase, nifedipine oxidase), substrate free, at 2.8 A resolution, residues 25-499
1W0F Cytochrome P450 3A4 from human (quinine 3-monooxygenase, nifedipine oxidase), complexed with substrate progesterone, at 2.65 A resolution
1W0G Cytochrome P450 3A4 from human (quinine 3-monooxygenase, nifedipine oxidase), complexed with inhibitor metyrapone, at 2.74 A resolution