M.S.: Parasitology, Biochemistry and Molecular Biology, University of Basel, Switzerland Ph.D.: Parasitology, Biochemistry and Molecular Biology, University of Basel, Switzerland Postdoctoral Fellow: Biochemistry and Molecular Biology, University of New Mexico School of Medicine

Office: BRF G23E Phone: 272 8157 e-mail: mbisoffi@salud.unm.edu

RESEARCH INTERESTS

• Molecular mechanisms of metastasis and androgen independence in prostate cancer.
• Field cancerization of breast and prostate tissues and clinical implications for diagnosis and prognosis .
• Telomere and telomerase biology.

STUDENT PROJECTS

• The role of the putative serine/threonine kinase GS3955 (Tribbles-2) in prostate cancer progession.
• Proteomic and metabolomic characterization of the LNCaP/C4-2/C4-2B cell model of prostate cancer progression.
• Proteomic characterization of epithelial and stromal cells of prostate tumors with high versus low telomere DNA content.
• Field cancerization of human breast tissue.

SELECTED PUBLICATIONS

Liu Y, Wan G, Bisoffi M, Heaphy CM, Leslie K, Griffith JK, Hu C, . Molecular and Cellular Biochemsitry. A Novel loss-of-function Mutation in TP53 in Endometrial Cancer. 297. 179-187. Jan 2007.
Heaphy CM, Hines WC, Butler KS, Haaland CM, Heywood G, Fischer E, Bisoffi M , Griffith JK, . Journal of Molecular Diagnostics. Assesment of the Frequecy of alleic Imbalance in Human Tissue Using a Multiplex PCR System. 9. 266-271. Jan 2007.

Heaphy CM, Bisoffi M, Fordyce CA, Haaland-Pullus CM, Hines WC, Joste NE, Griffith JK. International Journal of Cancer. Telomere DNA content and allelic imbalance demonstrate field concerization in histologically normal tissue adjacent to breast tumors. 119. 108-116. Jul 2006.
Fordyce CA, Heaphy CM, Joste NE, Bisoffi M, Wyaco JL, Mangalik A, Baumgartner KB, Baumgartner RN, Hunt WC, Griffith JK. Breast Cancer Research & Treatment. Telomere content correlates with stage and prognosis in breast cancer. 99. 193-202. Jul 2006.
Bisoffi M, Heaphy CM, Griffith JK. International Journal of Cancer. Telemeres: Prognostic markers for solid tumors. 119. 2255-60. Jul 2006.
Heaphy CM, Bisoffi M, Fordyce CA, Haaland Pullus CM, Hines WC, Joste NE, Griffith JK, . International Journal of Cancer . Telomere DNA content and allelic imbalance demonstrate field cancerization in histologically normal tissue adjacent to breast tumors. 119. 108-116. Jan 2006.
Bisoffi M., Klima I., Gresko E., Durfee P.N., Hines W.C., Griffith J.K., Studer U.E., Thalmann G.N. Expression profiles of androgen independent bone metastatic prostate cancer cells indicate up-regulation of the putative serine-threonine kinase GS3955. Journal of Urology (2004), 172: 1145-50.

Clément G., Bisoffi M., Finger A.N., Wetterwald A., Thalmann G.N., Cecchini M.G. Peptabodies as tools to test ligands isolated from phage displayed peptide libraries. Journal of Immunological Methods (2003), 276: 135-141.

Schmid M.C., Bisoffi M., Wetterwald A., Gautschi E., Thalmann G.N., Mitola S., Bussolino F., Cecchini M.G. Insulin-like growth factor binding protein-3 (IGFBP-3) is highly expressed in endothelial cells of neoangiogenic mouse tumor vessels. International Journal of Cancer (2003), 103,577-86.

Finger A.N., Bisoffi M., Wetterwald A., Gautschi E., Hohenfeld U., Klima I., Stadler B.M., Mazzucchelli L., Thalmann G.N., Cecchini M.G. Scavenger receptor block as strategy for the identification of bone marrow homing phages by panning in vivo random peptide phage displayed libraries. Journal of Immunological Methods (2002), 264, 173-86.

Adsan O., Cecchini M.G., Bisoffi M., Wetterwald A., Klima I., Danuser H.J., Studer U.E., Thalmann G.N. Can the reverse transcriptase-polymerase chain reaction for prostate specific antigen and prostate specific membrane antigen improve staging and predict biochemical recurrence? British Journal of Urology Int. ( 2002), 90, 579-85.

Bisoffi M., Chakerian A.E., Fore M.L., Bryant J.E., Moyzis R.K., Griffith J.K. Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA. European Journal of Cancer (1998), 34, 1242-1249 Bisoffi M., Betschart B. Isolation and sequence comparison of a cuticular collagen of Brugia pahangi. Parasitology (1996), 113, 145-155.

Bisoffi M., Marti S., Betschart B. Repetitive peptide motifs in the cuticlin of Ascaris suum. Molecular and Biochemical Parasitology (1996), 80, 55-64.

Bisoffi M., Betschart B. Ascaris suum: Molecular cloning of an intermediate filament of Ascaris suum. International Health and Tropical Medicine (1996), 1, 640-645.

Hines W.C., Fajardo A.M., Joste N.E., Bisoffi M., Griffith J.K. Quantitative and spatial measurements of TERT expression within normal and malignant human breast tissue. Submitted to Molecular Cancer Research.

Fordyce C.A., Heaphy C.M., Bisoffi M., Wyaco J.L., Hernandez J.P., Joste N.E., Mangalik A., Smith A.Y., Griffith J.K. Telomere DNA Content Predicts Clinical Recurrence of Breast Carcinoma and Prostate Adenocarcinoma Following Surgical Excision. Submitted to New England Journal of Medicine.

Heaphy C.M., Bisoffi M., Fordyce C.A., Haaland-Pullus C.M., Hines W.C., Joste N.E., Griffith J.K. Field Cancerization in Histologically Normal Tissue Adjacent to Breast Tumors as Determined by Telomere DNA Content and Allelic Imbalance. Submitted to Journal of Molecular Diagnostics.