William Anderson, Ph.D.
Chair

Marcy Osgood, Ph.D.
Undergraduate Program Director

Jeanne Marquardt
 Department Administrator
925-4095

Sheryl Cohn
Administrative Support
Supervisor
272-5148

Karla Banuelos
Administrative Asst. II
272-3539

Basic Medical Sciences
Rm 249
MSC 08 4670
Ph: 505-272-3333
Fax: 505-272-6587
JEFFREY K. GRIFFITH, Ph.D.
 


Professor

B.S. (Biology) Portland State University, 1970
Ph.D. (Biology) Purdue University, 1975
NIH Postdoctoral Fellow, Biochem & Molec Embryol, Univ. of Hawaii;1975-78
Woods Hole Marine Biological Laboratory, 1975


Office: Basic Medical Sciences Bldg, rm. 177
Telephone: (505) 272-2321
E-mail:JKGriffith@salud.unm.edu 

HONORS

1981, Los Alamos National Laboratory, Distinguished Performance Award.
Burroughs Welcome Travel Awards: Univ. of Cambridge, 1990,
Univ. of Leeds, 1994.
British Council Travel Award, Univ. of Cambridge, 1992.
Visiting Fellowship, Clare Hall, Univ. of Cambridge, 1991, elected to Lifetime Membership, 1992.
Faculty Excellence in Teaching Award, University of New Mexico, 1994, 1995.
RESEARCH INTERESTS
Breast and prostate cancer. Molecular markers of cancer progression and prognosis. Chromosome structure, organization, telomere biology, genetic polymorphism

Student Projects
Measurement of telomere content, allelic imbalance and telomerase activity in human cancers.

SELECTED PUBLICATIONS

Liu Y, Wan G, Bisoffi M, Heaphy CM, Leslie K, Griffith JK, Hu C, . Molecular and Cellular Biochemsitry. A Novel loss-of-function Mutation in TP53 in Endometrial Cancer. 297. 179-187. Jan 2007.

Heaphy CM, Hines WC, Butler KS, Haaland CM, Heywood G, Fischer E, Bisoffi M , Griffith JK, . Journal of Molecular Diagnostics. Assesment of the Frequecy of alleic Imbalance in Human Tissue Using a Multiplex PCR System. 9. 266-271. Jan 2007.

Candia BJ, Hines WC, Heaphy CM, Griffith JK, Orlando RA. Cancer Cell International. Protease Nexin-1 Expression is altered in Human Breast Cancer. 6. 16. Dec 2006.

Bisoffi M, Heaphy CM, Griffith JK, . International Journal of Cancer. Telomeres: Prognostic Markers for Solid Tumors. 119. 2255-2260. Dec 2006.

Liu Z , Wan G, Bisoffi M, Heaphy CM, Leslie K, Griffith JK, Hu C, . Molecular and Cellular Biochemistry. A Novel Loss-of-function Mutation in TP53 in Endometrial Cancer. Nov 2006.

Fordyce CA, Heaphy CM, Bisoffi M, Wyaco JL, Joste NE, Mangalik A, Baumgartner KB, Baumgartner RN, Hunt WC, Griffith JK. Breast Cancer Research and Treatment. Telomere Content Correlates with Stage and Prognosis in Invasis Breast Cancer. Jun 2006

Fordyce CA, Bisoffi M, Heaphy CM, Joste NE, Haaland C, Griffith JK. International Journal of Cancer. Telomere DNA Content and Allelic Imbalance in Histologically Normal Tissue Adjacent to Breast Tumors: Implications for Prognosis. 119. 108-116. Jan 2006.

Hines, WC, Fajardo, AM, Joste, NE, Bisoffi, M and JK Griffith (2005) Quantitative and Spatial Measurements of TERT Expression within Normal and Malignant Human Breast Tissue,  Molecular Cancer Research, in press.

C.A. Fordyce, C.M. Heaphy, N.E. Joste, A.Y. Smith, W.C. Hunt and J.K. Griffith (2005)   Association Between Cancer-free Survival and Telomere DNA Content in Prostate Tumors. J. Urology, 173: 610-614.

Bisoffi M, Klima I, Gresko E, Durfee P, Hines WC, Griffith JK. J. Uruology. Expression profiles of androgen-independent bone metastatic prostate cancer cells indicate over-expression of the putative serine-threonine kinase GS3955. 172. 1145-1150. Sep 2004.

C. Fordyce, C. Heaphy and J.K. Griffith. (2002) Chemiluminescent measurement of telomere DNA content in archival biopsy specimens. Biotechniques, 33: 144-6, 148.

J.K. Griffith,  J.E. Bryant, C. Fordyce, F. Gilliland N. Joste, and R.K. Moyzis (1999) Reduced telomere DNA content is correlated with genomic instability and metastasis in invasive human breast carcinoma. Breast Cancer Research and Treatment, 54: 59-64.

L. Donaldson,  C.F. Fordyce, F. Gilliland, A. Smith, R. Feddersen, N.E. Joste, R.K. Moyzis and J.K. Griffith (1999) Association between outcome and telomere DNA content in prostate cancer. Journal of Urology. 162: 1788-1792.

M. Bisoffi, A.E. Chakarian, M.F. Fore, J.E. Bryant, J.P. Hernandez, R.K Moyzis and J.K. Griffith (1998).  Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA, European Journal of Cancer, 34:1242-1249.