Department of Biochemistry & Molecular Biology


LAUREL SILLERUD, Ph.D.
 
Research Associate Professor






Office: BMSB-253      Lab: BMSB-284
Phone: 272-5511
Email: laurel@unm.edu

RESEARCH INTEREST

1.Metabolic regulation in the human prostate and its failure in cancer. Molecular biology of prostate cancer. The use of magnetic resonance spectroscopic and imaging methods for the detection and assessment of androgen-responsiveness of prostatic adenocarcinoma.

2.Non-invasive magnetic resonance imaging and spectroscopic assessment of function in the central, and peripheral nervous system. Functional imaging and spectroscopy of the CNS.

3.Development of NMR force microscopy for imaging of single atoms.

4.Application of stable isotopes in NMR determination of biomolecular structure, function and metabolism. Multiple quantum methods for editing spectra and images in vivo.

SELECTED PUBLICATIONS

Sillerud LO, Larson RS. Methods Mol. Biol. Nuclear magnetic resonance-based screening methods for drug discovery. 316. Jun 2006.

M. Shahinpoor, I. D. Norris, B. R. Mattis, K. J. Kim, and Laurel O. Sillerud. Electroactive Polyacrylonitrile Nanofibers as Artificial Nano-Muscles. Proceedings of the Society of PIE (2002) in press.

Laurel O. Sillerud, Arvind Caprihan, Nancy Berton, and Gary J. Rosenthal. "Efficacy of Recombinant Human Hemoglobin Determined by 31P -NMR Spectroscopy in Rats During Isovolemic Total Exchange Transfusion" Journal of Applied Physiology 86(1999)887-894.

Laurel O. Sillerud, Arvind Caprihan, "Efficacy of Blood Subsititutes Determined by 31P NMR Spectroscopy" NMR Newsletter #449 (1996)7-8.

Yoshizawa, T., Nose, T., Moore, Gregory J., and Sillerud, Laurel O . "Functional Magnetic Resonance Imaging Of Motor Activation in the Human Cervical Spinal Cord." NeuroImage (1996)174-182.

Francisco A. Tomei, Larry L. Barton, and Laurel O. Sillerud "Tranformation of selenate and selenite to elemental selenium by Desulfovibrio desulfuricans." Journal of Industrial Microbiology 14(1995)329-337.

Neeman, M., Gibel, L. J., Smith, S. M., Hartford, A., Sterling, W. and Sillerud, Laurel O. "NMR Microscopy of Water Diffusion and Edema During Hypothermic Preservation of Rat Kidney." Journal of Urology 152(1994)1287-1291.

Moore, Gregory J. and Sillerud, Laurel O. "The pH Dependence Of Chemical Shift And Spin-Spin Coupling For Citrate." Journal of Magnetic Resonance B103(1994)87-88.

L. L. Barton, F. A. Fekette, M. M. E. Huybrechts, and Laurel O. Sillerud "Applications of Biotechnology in Management of Industrial Wastes Containing Toxic Metals." Radioactive Waste Management and the Nuclear Fuel Cycle 18(1994)13-21.

Moore, G. J., Sanders, J. A., and Sillerud, L. O. "Zero quantum difference spectroscopy for strongly-coupled systems." Journal of Magnetic Resonance A104(1993)111-114.

Sanders JA and Sillerud, LO. Proton STEAM spectroscopy of the human prostate in vivo. Proc. Soc. Magn. Reson. Med. 12(1993)1029.

T. Yoshizawa, J. A. Sanders, G. J. Moore, M.D. McKay, T. Nose, and Laurel O. Sillerud "Functional MRI of Spinal Cord Activity During a Motor Task" Proc. Soc. Magn. Reson. 12 (1993) 348.

Sanders JA, Thomasson DM, and Sillerud LO. 1-Dimensional proton chemical shift imaging of the human prostate in vivo. Proc. Soc. Magn. Reson. Med. 11 (1992) 3305.

Halliday KR, Sillerud LO and Mickey DD. 13C NMR detection of taurine discriminates androgen-insensitive from androgen sensitivie Dunning prostate tumors. Proc. Soc. Magn. Reson. Med. 11(1992)492.

Thomas A. Zawodzinski, T. E. Springer, Michal Neeman, Laurel O. Sillerud " Diffusion Barriers in pulsed-gradient spin-echo NMR microscopy" Israel Journal of Chemistry 32(1992)281-290.

James P. Freyer, Patricia L. Schor, Kathryn A. Jarrett, Michal Neeman and Laurel O. Sillerud "Cellular Energetics Measured by Phosphorus NMR spectroscopy are not Correlated with Chronic Nutrient Deficiency in Multicellular Tumor Spheroids." Cancer Research 51(1991)3831-3837.

Michal Neeman, Kathryn A. Jarrett, Laurel O. Sillerud, and James P. Freyer "Self Diffusion of Water in Multicellular Spheroids Measured by Magnetic Resonance Microimaging." Cancer Research 51(1991)4072-4079.

Michal Neeman, James P. Freyer and Laurel O. Sillerud "A Simple Method for Obtaining Cross-Term-Free Images for Diffusion Anisotropy Studies in NMR Microimaging" Magnetic Resonance in Medicine 21(1991)138-143.

Thomas A. Zawodzinski, Michal Neeman, Laurel O. Sillerud and Shimshon Gottesfeld "Determination of Water Diffusion Coefficients in Perfluorosulfonate Ionomeric Membranes" Journal of Physical Chemistry 95(1991)6040-6044.

Michal Neeman, James P. Freyer and Laurel O. Sillerud "Pulsed-Gradient Spin-Echo Diffusion Studies in NMR Imaging. Effects of the Imaging Gradients on the Determination of Diffusion Coefficients." Journal of Magnetic Resonance 90(1990)303-312.

Laurel O. Silleurd, James. P. Freyer, Michal Neeman, and Mark A. Mattingly "Proton NMR Microscopy of Multicellular Tumor Spheroid Morphology" Magnetic Resonance in Medicine. 16(1990)380-389.

James P. Freyer, Nancy H. Fink, Patricia L. Schor, James R. Coulter, Michal Neeman and Laurel O. Sillerud "A System for Viably Maintaining a Stirred Suspension of Multicellular Spheroids During NMR Spectroscopy" NMR in Biomedicine 9(1990)195-205.