Honglian Shi, Ph.D.
Oxidative Stress Core Co-director.
Research Associate Professor of
Pharmaceutical Sciences
UNM College of Pharmacy
hshi@salud.unm.edu
Biographical Sketch:
Dr. Shi has
received a PhD in biophysics with a
specialization in free radical research. He joined College of
Pharmacy of the University of New Mexico in 2001, and is
the P.I. of project 1 at COBRE program. His
project is to
study the role of redox status and hypoxia inducible factor 1
in cell death/survival in stroke with multidisciplinary
approaches such as electron paramagnetic resonance, MRI, and cellular and
molecular techniques.
Recent publications
Noguchi N, Watanabe A, and Shi H. Diverse functions of antioxidants. Free Radic Res 33:809-817; 2000.
Shi H, Noguchi N, and Niki E. Galvinoxyl method for standardizing electron and proton donation activity. Methods in Enzymology 335:155-166; 2001.
Shi H, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Attention to relative response across sequential electrodes improves quantitation of coulometric array. Anal Biochem 302:239-245; 2002.
Shi H, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Characterization of diet-dependent metabolic serotypes: proof of principle in female and male rats. J Nutrition 132: 1031-1038; 2002.
Shi H, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Characterization of diet-dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of rats. J Nutrition 132: 1039-1046; 2002.
Burdick AD, Davis JW II, Liu KJ, Hudson LG, Shi H, Monske ML, and Burchiel SW. Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in MCF-10A cells. Cancer Res 63: 7825-7833; 2003.
Liu S, Shi H, Liu W, Furuichi T, Timmins G, and Liu K. Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cerebr Blood Flow Metab 24: 343-349; 2004.
Liu W, Rosenburg GA, Shi H, Furuichi T, Timmins G, Cunningham LA, and Liu KJ. Xanthine oxidase activates gelatinase A (MMP-2) in cultured rat vascular smooth muscle cells through proteolytic activities. Arch Biochem Biophys 426: 11-17; 2004.
Shi H, Hudson LG, Ding W, Wang S, Cooper KL, Liu S, Shi X, and Liu KJ. Free radical generation and DNA damage by arsenite in keratinocytes. Chem Res Toxicol 17: 871-878; 2004.
Liu S, Timmins G, Shi H, Gasparovic CM, and Liu KJ. Application of in vivo EPR in brain research: monitoring tissue oxygenation, blood flow, and oxidative stress. NMR in Biomedicine 17:327-334; 2004.
Shi H, Paolucci U, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Development of biomarkers based on diet-dependent metabolic serotypes: practical issues in development of expert system-based classification models in metabolomic studies. OMICS J Integr Biol 8 (3): 197-208; 2004.
Paolucci U, Vigneau-Callahan KE, Shi H, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Development of biomarkers based on diet-dependent metabolic serotypes: concerns and approaches for cohort and gender issues in serum metabolome studies. OMICS J Integr Biol 8 (3): 209-220; 2004.
Paolucci U, Vigneau-Callahan KE, Shi H, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Development of biomarkers based on diet-dependent metabolic serotypes: characteristics of component-based models of metabolic serotypes. OMICS J Integr Biol 8 (3): 221-238; 2004.
Furuichi T, Liu W, Shi H, Miyake M, and Liu K. Generation of hydrogen peroxide during brief oxygen-glucose deprivation induces preconditioning neuronal protection in primary cultured neurons. J Neurosci Res 79 (6): 816 - 824; 2005.
Liu Z, Lu H, Shi H, Du Y, Yu J,Gu S, Chen X, Liu K, and Hu C. PUMA Overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. Cancer Res 65(5): 1647-54; 2005.
Shi H, Timmins G, Monske1 M, Burdick A, Kalyararaman B, Liu Y, Clément J, Burchiel S, and Liu J. Evaluation of spin trapping agents and trapping conditions for detection of cell-generated superoxide. Arch Biochem Biophys 437(1):59-68; 2005.
Shi H, Liu S, Miyake M, and Liu K. Ebselen induced C6 glioma cell death in oxygen and glucose deprivation. Chem Res Toxicol 19: 655-660; 2006.
Miyake M, Shen J, Liu S, Shi H, Liu W, Yuan Z, Pritchard A, Kao J, Liu K, and Rosen GM. Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. J Pharmacol Exp Ther 318:1187-1193; 2006.
Shi H, and Liu K. Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia. Neurosci Lett 410: 57-61; 2006.
Ju W, Wang X, Shi H, Belinsky SA, and Lin Y. A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol 71:1381-1388; 2007.
Guo S, Wharton W, Moseley P, and Shi H. Overexpression of heat shock protein 70 reduces cell injury induced by oxygen and glucose deprivation through enhancing cellular reducing capacity. Cell Stress and Chaperones 12(3):245-254; 2007.
Guo S, Bragina O, Cao Z, Xu Y, Chen H, Jiang BH, Lin Y, Liu K, and Shi H. Glucose upregulates HIF-1α expression in primary cultured cortical neurons in response to hypoxia. J Neurochem (in press)