Non-invasive imaging modalities such as Magnetic Resonance Imaging (MRI) and Spectroscopy offer the opportunity to measure brain antimicrobial pharmacodynamics (PD). We have developed a rat model of Cryptococcus neoformans meningoencephalitis (CNME) that mimics the pathological features noted in AIDS patients infected with this oppportunistic fungus. The BRaN center provides the necessary instrumentation and technical expertise to image CNME progression and quantify the antifungal pharmacologic effects. The long-term goals of our work are to identify an antifungal combination regimen that reduces fungal burden and prevents the emergence of resistance. This could translate into improved clinical outcomes for AIDS patients with this high mortality-associated disease.

Julia M. Stephen, Ph.D., specializes in MEG research investigating both sensory and cognitive functioning, including basic functioning of the visual system as well as clinical research to identify early markers of neural dysfunction. Her current interest is in using the exquisite temporal resolution of MEG to better understand the mechanism(s) of multisensory integration in both infant and adult populations. While continuing to better understand normal and abnormal functioning in adults, she has recently begun to investigate how the infant and toddler brain develops using the prototype babySQUID® MEG system.

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