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E V E N T S

All seminars are held in Domenici Hall room 1023 at 4 pm the day of the seminar unless otherwise noted.

Vincent J. Leonard, University Fire Marshal
Safety and Risk Services (SRS)

will give a talk on Fire Safety and Egress at 10 Am on June 17, Domenici hall rm 1023

 

We will break for the summer and resume seminars in the fall.

 Link to EAC meeting photos.

 

O P P O R T U N I T I E S

The applications have closed for this pilot project funding.The UNM BRaIN Imaging Center will accept applications from the entire UNM faculty for pilot research projects to be funded for 5 months (July 1 - November 30, 2008). Four awardees will receive $15,000 each. Proposals should be in the area of neuroimaging/neuroscience and utilize one or more imaging modalities, including optical, magnetic or electrical combined with cellular/molecular biology or in the area of computational neuroscience with a direct link to CNS pathophysiology. It should be an extension or an off-shoot of an ongoing project.

 

Job Openings:

    We are interested in expanding our international group of scientists who are interested in working with us in the area of neuroimaging in animal models and basic and clinical human studies.
     Areas of interest include: technology development in MRI, MEG, EEG, EPR, Optical, Cell/Molecular techniques and research in neuroscience (stroke, epilepsy, traumatic brain injury, neurodegeneration, neural replacement with stem cells, signalling pathway, mitochondrial functions, nanoparticle labeling, quantum dots, brain development, autism, neuroscience-informed early childhood education or NIECE, cerebral palsy, etc.) Contact Jean Pimentel for more information.

P U B L I C A T I O N S

2007 Publications

Angelova, P. and Müller, W. 2006. Oxidative Modulation of the transient potassium current IA by intracellular arachidonic acid in rat CA1 pyramidal neurons. Eur J Neurosci, 23: 2375-84.

Azimi-Zoonz, A., Shuttleworth, C.W. and Connor, J.A. GABAergic protection of hippocampal pyramidal neurons against glutamate insult: deficit in young animals compared to adults. Journal of Neurophysiology 96 (2006) 299-308.

Brennan, A,. Connor, J.A. & Shuttleworth C.W. NAD(P)H fluorescence transients following synaptic activity in brain slices: Predominant role of mitochondrial function. Journal of Cerebral Blood Flow and Metabolism 26 (2006) 1389-406.

Chinopoulos, C., Connor, J.A. and Shuttleworth, C.W. Emergence of a spermine-sensitive, non-inactivating conductance in mature hippocampal CA1 pyramidal neurons upon reduction of extracellular Ca2+: dependence on intracellular Mg2+ and ATP. Neurochemistry International 50 (2007) 148-158.

Guo S, Wharton W, Moseley P, and Shi H.  Overexpression of heat shock protein 70 reduces cell injury induced by oxygen and glucose deprivation through enhancing cellular reducing capacity.  Cell Stress and Chaperones 12(3):245-254; 2007.

Guo S, Bragina O, Cao Z, Xu Y, Chen H, Jiang BH, Lin Y, Liu K, and Shi H. Glucose upregulates HIF-1α expression in primary cultured cortical neurons in response to hypoxia. J Neurochem (in press)

H. Shi, K.J. Liu, "Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion", Frontiers in Bioscience, 12, 1318-28 (2007).

H. Shi, K.J. Liu, “Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion”, Frontiers in Bioscience, 12, 1318-28 (2007).

Hoskison, M.M. and Shuttleworth, C.W. Microtubule disruption, not calpain-dependent loss of MAP2, contributes to enduring NMDA-induced dendritic dysfunction in acute hippocampal slices. Experimental Neurology 202 (2006) 302-12.

J. Shen, S. Ma, P. Chan, R.T.F. Cheung, P.C.W. Fung, Y. Tong, K.J. Liu, "Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury", J. Neurochem., 96, 1078-1089 (2006).

Ju W, Wang X, Shi H, Belinsky SA, and Lin Y.  A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol 71:1381-1388; 2007.

Müller, A. Kukley, M. Uebachs, P. Stausberg, M. Podlogar, H.Beck, Müller W., Dietrich, D. 2005 Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neurons. J. Neurosci. 25: 558-565.

Murakami S, Okada Y.
Contributions of principal neocortical neurons to magnetoencephalography and electroencephalography signals. J Physiol. 2006 Sep 15;575(Pt 3):925-36. Epub 2006 Apr 13.

Mun-Bryce S, Roberts L, Bartolo A, Okada Y.
Transhemispheric depolarizations persist in the intracerebral hemorrhage swine brain following corpus callosal transection. Brain Res. 2006 Feb 16;1073-1074:481-90. Epub 2006 Jan 27.

Pfefferbaum A, Adalsteinsson E, Sood RR, Mayer D, Mcbride W. J., Bell, R. L., Sullivan E. A Longitudinal MRI Study of Brain Growth of the Adult Wistar Alcohol-Preferring Rat. ACER 2006; 30: 1234.

S. Liu, W.L. Liu, W. Ding, M. Miyake, G.A. Rosenberg, K.J. Liu, "Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia", J. Cereb. Blood Flow Metab., 26, 1274-1284 (2006).

Shi H, Timmins G, Monske1 M, Burdick A, Kalyararaman B, Liu Y, Clément J, Burchiel S, and Liu J. Evaluation of spin trapping agents and trapping conditions for detection of cell-generated superoxide. Arch Biochem Biophys 437(1):59-68; 2005.

Shi H*, Liu S, Miyake M, and Liu K. Ebselen induced C6 glioma cell death in oxygen and glucose deprivation. Chem Res Toxicol 19: 655-660; 2006.

Miyake M, Shen J, Liu S, Shi H, Liu W, Yuan Z, Pritchard A, Kao J, Liu K, and Rosen GM. Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. J Pharmacol Exp Ther 318:1187-1193; 2006.

Shi H, and Liu K. Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia. Neurosci lett 410: 57-61; 2006.

Sood RR, Taheri S, Estrada E, Rosenberg G
Quantitative evaluation of the effect of Propylene Glycol on BBB opening. JMRI 2007; 25: 39

Stanton P.K., Winterer, J., Zhang X.L., and Müller W. 2005 Imaging LTP of presynaptic release of FM1-43 from the rapidly recycling vesicle pool of Schaffer collateral-CA1 synapses in rat hippocampal slices. Eur J Neurosci 22:2451-61.

Steven P. Braithwaite, Surojit Paul, Angus C. Nairn and Paul J. Lombroso, Synaptic plasticity: one STEP at a time. Trends Neurosci. 2006 Aug;29(8):452-8. Epub 2006 Jun 30. Review.

Sullivan E, Adalsteinsson E, Sood RR, Mcbride, W. J., Bell, R. L., Mayer D,Pfefferbaum A., Effects of Voluntary Chronic Alcohol Consumption on Brain in the Alcohol-Preferring Rat: A Quantitative Longitudinal MRI Study. ACER 2006; 30: 1248.

Taheri S, Sood RR, Spin lock MRI with amplitude and phase modulated adiabatic waveforms: An MR simulation study. MRI 2006; 24: 51.

Taheri S, Sood RR, Application of Kalman filter for reliable estimation of BBB permeability coefficient values using Patlak plot method. MRI 2006; 24: 1039.

Taheri S, Sood RR, Partial volume compensation for improved reliability of MRI based BBB permeability coefficient estimate, Journal of MRI, 2007, June 25 (15) 613-625.

Tyler, W.J., Zhang, X.L., Winterer, J., Müller, W., Stanton P.K., and Pozzo-Miller, L. 2006 BDNF Increases Release Probability and the Size of the Readily Releasable Pool in Hippocampal Excitatory Synapses. J Physiol, 574: 787-803.

W. Liu, G.A. Rosenberg, K.J. Liu, "AUF-1 mediates inhibition by nitric oxide of LPS-induced matrix metalloproteinase-9 expression in cultured astrocytes", J. Neurosci. Res., 84, 360-369 (2006).

Winterer, J., Stanton P.K., and Müller W. 2006 Direct Monitoring of Vesicular Release and Uptake in Brain Slices by multiphoton excitation of FM1-43. BioTechniques 40:343-350.

Y.P. Liu, L.F. Wang, Z. Nie, Y.Q. Ji, Y. Liu, K.J. Liu, Q. Tian, "Effect of the phosphoryl substituent in the linear nitrone on the spin trapping of superoxide radical and the stability of the superoxide adduct: combined experimental and theoretical studies", J. Org. Chem, 71, 7753-7762 (2006).

Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab. 2006 Jul 19

Zhang T, Okada Y. Recursive artifact windowed-single tone extraction method (RAW-STEM) as periodic noise filter for electrophysiological signals with interfering transients. J Neuroscience Methods. 2006 Sep 15;155(2):308-18. Epub 2006 Feb 8.

Zhang, X.L., Zhou, Z., Winterer, J., Müller, W., and Stanton P.K. 2006 NMDA-dependent, but not group I mGluR-dependent, LTD at Schaffer collateral-CA1 synapses is associated with longterm reduction of release from the rapidly recycling presynaptic vesicle pool. J. Neurosci. 26:10270-8.

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2006 Publications

Angelova, P. and Müller, W. 2006. Oxidative Modulation of the transient potassium current IA by intracellular arachidonic acid in rat CA1 pyramidal neurons.  Eur J Neurosci, 23: 2375-84.

Azimi-Zoonz, A., Shuttleworth, C.W. and Connor, J.A.  GABAergic protection of hippocampal pyramidal neurons against glutamate insult: deficit in young animals compared to adults.  Journal of Neurophysiology 96 (2006) 299-308.

Brennan, A,. Connor, J.A. & Shuttleworth C.W.  NAD(P)H fluorescence transients following synaptic activity in brain slices: Predominant role of mitochondrial function.  Journal of Cerebral Blood Flow and Metabolism 26 (2006) 1389-406.

Hoskison, M.M. and Shuttleworth, C.W.  Microtubule disruption, not calpain-dependent loss of MAP2, contributes to enduring NMDA-induced dendritic dysfunction in acute hippocampal slices.  Experimental Neurology 202 (2006) 302-12.

J. Shen, S. Ma, P. Chan, R.T.F. Cheung, P.C.W. Fung, Y. Tong, K.J. Liu, “Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury”, J. Neurochem., 96, 1078-1089 (2006).

Miyake M, Shen J, Liu S, Shi H, Liu W, Yuan Z, Pritchard A, Kao J, Liu K, and Rosen GM.  Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. J Pharmacol Exp Ther 318:1187-1193; 2006.

Müller, A. Kukley, M. Uebachs, P. Stausberg, M. Podlogar, H.Beck, Müller W., Dietrich, D. 2005 Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neurons. J. Neurosci. 25: 558-565.

Murakami S, Okada Y. Contributions of principal neocortical neurons to magnetoencephalography and electroencephalography signals. J Physiol. 2006 Sep 15;575(Pt 3):925-36. Epub 2006 Apr 13.

Mun-Bryce S, Roberts L, Bartolo A, Okada Y. Transhemispheric depolarizations persist in the intracerebral hemorrhage swine brain following corpus callosal transection.  Brain Res. 2006 Feb 16;1073-1074:481-90. Epub 2006 Jan 27.

Pfefferbaum A, Adalsteinsson E, Sood RR, Mayer D, Mcbride W. J., Bell, R. L., Sullivan E. A Longitudinal MRI Study of Brain Growth of the Adult Wistar Alcohol-Preferring Rat. ACER 2006; 30: 1234.

S. Liu, W.L. Liu, W. Ding, M. Miyake, G.A. Rosenberg, K.J. Liu,  “Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia”, J. Cereb. Blood Flow Metab., 26, 1274-1284 (2006).

Shi H, Timmins G, Monske1 M, Burdick A, Kalyararaman B, Liu Y, Clément J, Burchiel S, and Liu J.  Evaluation of spin trapping agents and trapping conditions for detection of cell-generated superoxide. Arch Biochem Biophys 437(1):59-68; 2005.

Shi H*, Liu S, Miyake M, and Liu K.   Ebselen induced C6 glioma cell death in oxygen and glucose deprivation. Chem Res Toxicol 19: 655-660; 2006.

Shi H, and Liu K.  Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia.  Neurosci lett 410: 57-61; 2006.

Sood RR, Taheri S, Estrada E, Rosenberg G. Quantitative evaluation of the effect of Propylene Glycol on BBB opening. JMRI 2007; 25: 39

Stanton P.K., Winterer, J., Zhang X.L., and Müller W. 2005 Imaging LTP of presynaptic release of FM1-43 from the rapidly recycling vesicle pool of Schaffer collateral-CA1 synapses in rat hippocampal slices. Eur J Neurosci 22:2451-61.

Steven P. Braithwaite, Surojit Paul, Angus C. Nairn and Paul J. Lombroso, Synaptic plasticity: one STEP at a time. Trends Neurosci. 2006 Aug;29(8):452-8. Epub 2006 Jun 30. Review.

Sullivan E, Adalsteinsson E, Sood RR, Mcbride, W. J., Bell, R. L., Mayer D, Pfefferbaum A., Effects of Voluntary Chronic Alcohol Consumption on Brain in the Alcohol-Preferring Rat:  A Quantitative Longitudinal MRI Study. ACER 2006; 30: 1248.

Taheri S, Sood RR, Spin lock MRI with amplitude and phase modulated adiabatic waveforms: An MR simulation study. MRI 2006; 24: 51.

Taheri S, Sood RR, Application of Kalman filter for reliable estimation of BBB permeability coefficient values using Patlak plot method. MRI 2006; 24: 1039.

Taheri S, Sood RR, Partial volume compensation for improved reliability of MRI based BBB permeability coefficient estimate, Journal of MRI, 2007, June 25 (15) 613-625.

Tyler, W.J., Zhang, X.L., Winterer, J., Müller, W., Stanton P.K., and Pozzo-Miller, L. 2006 BDNF Increases Release Probability and the Size of the Readily Releasable Pool in Hippocampal Excitatory Synapses. J Physiol, 574: 787-803.

W. Liu, G.A. Rosenberg, K.J. Liu, “AUF-1 mediates inhibition by nitric oxide of LPS-induced matrix metalloproteinase-9 expression in cultured astrocytes”, J. Neurosci. Res., 84, 360-369 (2006).

Winterer, J., Stanton P.K., and Müller W. 2006 Direct Monitoring of Vesicular Release and Uptake in Brain  Slices by multiphoton excitation of FM1-43. BioTechniques 40:343-350.

Y.P. Liu, L.F. Wang, Z. Nie, Y.Q. Ji, Y. Liu, K.J. Liu, Q. Tian, “Effect of the phosphoryl substituent in the linear nitrone on the spin trapping of superoxide radical and the stability of the superoxide adduct: combined experimental and theoretical studies”, J. Org. Chem, 71, 7753-7762 (2006).

Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in       cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat.  J Cereb Blood Flow Metab. 2006 Jul 19

Zhang T, Okada Y. Recursive artifact windowed-single tone extraction method (RAW-STEM) as periodic noise filter for electrophysiological signals with interfering transients. J Neuroscience Methods. 2006 Sep 15;155(2):308-18. Epub 2006 Feb 8.

Zhang, X.L., Zhou, Z., Winterer, J., Müller, W., and Stanton P.K. 2006 NMDA-dependent, but not group I mGluR-dependent, LTD at Schaffer collateral-CA1 synapses is associated with longterm reduction of release from the rapidly recycling presynaptic vesicle pool. J. Neurosci. 26:10270-8.

back to top