Cunningham, Lee Anna

  R01 NS47373-01:    
  Title: Metalloproteinase regulation of neuronal death
  This proposal is to investigate the convergence of metalloproteinase activity and
  death receptor signaling in neurons, utilizing both in vitro and in vivo models of
   ischemic injury, coupled with pharmacologic and gene deletion approaches.

  LIU, KE JIAN

  R01 AG031725 (K.J. Liu)
  Title: Effect of tissue pO2 on free-radical damage in stroke
  This project will test the hypothesis that low levels of localized tissue pO2 during
  focal cerebral ischemia result in an increased generation of free radicals, which in
  turn activates deleterious molecular events, including the activation of matrix
  metalloproteinase (MMP) and the caspase cascade, leading to microvascular
  damage and cell death.

  R01 ES015826 (K.J. Liu)    
  Title: Arsenic-enhanced skin carcinogenesis by UV radiation
  The proposed studies will address the critical issue of underlying mechanisms of
  arsenic as a co-carcinogen and help us design effective and target-specific
  intervention strategies against skin cancer induced by combined exposure to arsenic
  and UVR.

  American Heart Association                     
  Title: Effect of tissue pO2 on cerebral damage in ischemic stroke
  The overall goal of this project is to test the hypothesis that the time course of local
  tissue oxygenation status in evolving cerebral ischemia plays a significant
  pathophysiological role and can be used to predict the viability of affected tissue.
 

   PAUL, SUROJIT

  NIH1 R01 NS059962-01 
  Title: Role of a brain specific tyrosine phosphatase, STEP, in
  neuroprotection and death

 
  ROSENBERG, GARY

  R01 NS045847-01A1
  Agency:  NIH/NINDS   
  Title: Matrix metalloproteinase and the Blood-Brain Barrier
  This project will focus on the role of MMPs in regulation of the blood brain barrier
  after LPS-induced inflammation and cerebral ischemia. 

  Agency:  Johnson & Johnson  
  Title:  Matrix metalloproteinase inhibitors in treatment of stroke.
  The goal of this project is to test novel MMP inhibitors in a rat model of stroke.
  NIH R01 NS052305-01:   Pathobiology of Vascular Cognitive Impairment.

  SHI, HONGLIAN

  American Heart Association (0565508Z)
  Title: Beginning Grant in Aid Redox Regulation of HIF-1a in Cerebral
  Ischemia
  The goal of this project is to investigate effect of cellular reduction/oxidation
  changes on hypoxia inducible factor-1alpha, VEGF, and EPO at their protein level
  in cerebral ischemia with biochemical analyses

  R01NS058807   NIH  
  Title: Mechanism of Hypoxia Inducible Factor 1 in Cerebral Ischemia
  The goal of this project is to study the oxidative stress and its role in hypoxia
  inducible factor 1 (HIF-1) stability in ischemic brains utilizing multidisciplinary
  approaches.  Oxidative stress will be analyzed using various available techniques,
  including HPLC, fluorescence labeling, in vitro and in vivo EPR spectroscopy, and
  biochemical analyses.  Ischemic outcomes will be evaluated by MRI and
  histological analyses.  HIF-1 expression will be investigated by Western Blott and
  immunohistochemistry.

  P20 RR15636 NIH  
  Title: Integrative Program in CNS Pathophysiology Research
  This is a special project by the NCRR to help develop junior investigators in
  becoming independently funded scientists. It was used to establish a Center of
  Biomedical Research Excellence (COBRE) to help the junior investigators. These
  investigators are funded to carry out 4 projects in CNS pathophysiology using an
  integrative, multimodal approach, including stroke, epilepsy, and Parkinson’s
  disease.

  SHUTTLEWORTH, C. WILLIAM

  5 R01 NS051288-02    
  Title: Imaging Mitochondrial Function in Excitotoxicity

  TIMMINS, GRAHAM

  1R21CA113687-01A1  
  Title: Molecular Imaging of Melanoma by EPR  
  The PI is to develop novel imaging approaches to image melanoma in an M.
  domestica model

  1R21AI063486-01A2
  Title: Antimycobacterial NO from KatG Activation of isoniazid      
  The PI is to investigate mechanisms of how nitric oxide, one of the major innate
  immune effectors against TB, is also produced by bacterial metabolism of isoniazid
  & to delineate its antimycobacterial effects

  5RO3CA119320-02
  Title: Molecular Surrogate for Melanoma Prevention
  PI Will develop molecular surrogates for UV causation of melanoma and develop
  novel chemopreventive agents against melanoma.

 OKADA, YOSHIO

  DOE/MIND RESEARSCH NETWORK   Subaward “Neurodevelopment
  Research Program“

  1 R21 NS057614-01 
  Title: Cortical current imaging in human infants with babySQUID 

  ZHAO, XINYU

  NIH1 R01 MH080434-01
  Title: Role of small RNA in depression disorder
  The goal of this project is to investigate how MBD1 regulation of noncoding small
  RNA is involved in adult neurogenesis and depression disorder.

  NIH/NIMH 1 R01 MH078972-01
  Title: Translational Regulation in Adult Neural Stem Cells
  The goal of this project is to investigate how adult neurogenesis and adult neural
  stem cells are regulated at protein translational levels by RNA binding proteins and
  microRNA pathways.

  International Rett Syndrome Foundation 
  Title: Effect of MeCP2 mutation on neuronal maturation and function in
  heterozygote females
  The goal of this project is to investigate how Mecp2 mutation affects neuronal
  functions, for a better understanding of the etiology of Rett Syndrome.

  International Rett Syndrome Foundation
  Title: Function of MeCP2 in postnatal neuronal maturation
  The goal of this project is to investigate how Mecp2 mutations affect neuronal
  maturation in a Mecp2 null mouse model, for a better understanding of the etiology
  of Rett Syndrome.

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