The understanding of the biological and molecular processes
underlying the formation
and maintenance of central and peripheral nervous system myelin.
Molecular mechanism of
protein S-nitrosation. Pathophysiology of demyelinating disorders,
specifically multiple
sclerosis and adrenoleukodystrophy. Oxidative protein damage in
inflammatory demyelination.
Medical Biochemist, University of Buenos Aires, Argentina 1979
Ph.D. Biochemistry, University of Buenos Aires, Argentina, 1983
Post-Doctoral Education (1984-1990): Department of Biochemistry E.K. Shriver
Center for
Mental Retardation, Waltham, MA., Department of Biological Chemistry and
Molecular
Pharmacology, Harvard Medical School, Boston, MA. and Department of Neurology,
Massachusetts General Hospital, Boston, MA.
Sch. of Pharm. & Biochem.Award to the best doctoral thesis- Univ. Buenos Aires
1984.
Jordi-Folch Memorial Award (Am. Soc. Neurochem.) for outstanding contributions
to
neuroscience research 1987.
Member, Iberoamerican Soc. Neurochem. (founder member, 1987-)
Member of the Am. Soc. Neurochem (1985 -)
Member of the Inter. Am. Soc. Neurochem. (1983 -),
Am. Soc. Biochem & Mol. Biol. (1988-)
Ad-hoc Reviewer for Brain Research,; J. Neurochem.; J. Neuroscience Research;
Biochem.
Biophys. Acta; Anal. Biochem.; J. Biol. Chem. and Neurochem. Res. (1986-)
Reviewer for NIH -NINDS (1998-)
Ad-hoc Reviewer for the National Multiple Sclerosis Society (1998-).
Bizzozero, O.A., DeJesus, G. , and Howard, T. (2004) Exposure of rat optic
nerves to nitric oxide
causes protein S-nitrosation and myelin decompaction.
Neurochem.
Res. 29: 1675-1685.
DeJesus, G. and Bizzozero, O.A. (2002) Effect of 2-fluoropalmitate, cerulenin
and tunicamycin on the
palmitoylation and intracellular translocation of myelin proteolipid protein.
Neurochem. Res. 27: 1669-1675.
Bizzozero, O.A., and Howard, T. (2002) Myelin proteolipid protein-induced
aggregation of lipid vesicles:
efficacy of the various molecular species.
Neurochem. Res. 27: 1269-1277.
Bizzozero, O.A., Malkoski, S.P., Mobarak, C., Bixler, H.A. and Evans, J. (2002)
Mass-spectrometric
analysis of myelin proteolipids reveals new features of this family of
palmitoylated membrame proteins.
J. Neurochem. 81: 636-645.
Bizzozero, O.A., Bixler, H.A., Parkhani, J., and Pastuszyn, A. (2001) Nitric
oxide reduces the
palmitoylation of myelin proteolipid protein by an indirect mechanism.
Neurochem. Res. 26, 1127-1137.
Bizzozero, O.A., Bixler, H.A., and Pastuszyn, A. (2001) Structural determinants
influencing the
reaction of cysteine-containing peptides with palmitoyl-CoA and other thioesters.
Biochem. Biophys. Acta
1545: 278-288.
Bizzozero, O.A., Bixler, H.A, Davis, J., Espinosa, A. and Messier, A.M. (2001)
Chemical deacylation
reduces the adhesive properties of proteolipid protein and leads to decompaction
of the myelin sheath.
J. Neurochem. 76: 1129-1141.
Messier, A. and Bizzozero O.A. (2000) Conserved fatty acid composition of
proteolipid protein during
brain development and in myelin subfractions.
Neurochem. Res. 24: 449-455.
Bizzozero, O.A., Sanchez, P. and Tetzloff, S.U. (1999) Effect of ATP-depletion
on the palmitoylation
of myelin proteolipid protein in young and adult rats.
J. Neurochem. 72, 2610-2616.
Sanchez, P., Tetzloff, S.U., and Bizzozero, O.A. (1998) Veratridine-induced
depolarization reduces
the palmitoylation of brain and myelin glycerolipids.
J. Neurochem. 70, 1448-1457.
Tetzloff, S.U. and Bizzozero, O.A. (1998) Palmitoylation of proteolipid protein
from rat brain
myelin using endogenously-generated 18 O-fatty acids.
J. Biol. Chem. 273:279-285.
Bharadwaj, M. and Bizzozero, O.A. (1995) Myelin PO Glycoprotein and a synthetic
peptide containing
the palmitoylation site are both autoacylated with palmitoyl-CoA.
J. Neurochem. 65:1805-1815.
Bizzozero, O.A. (1995) Chemical analysis of acylation sites and species.
Methods in Enzymology
250: 361-379.
Bizzozero, O.A., Fridal, K. and Pastuszyn, A. (1994) Identification of the
palmitoylation site
in rat myelin PO glycoprotein.
J. Neurochem. 62:1163-1171.
Bizzozero, O.A., Leyba, J., and Nunez, D.J. (1992) Characterization of
proteolipid protein
fatty acylesterase from rat brain myelin.
J. Biol. Chem. 267:7888-7894.
Bizzozero, O.A. and Good, L. (1991) Rapid metabolism of fatty acids covalently
bound to myelin
proteolipid protein.
J. Biol. Chem. 266:17092-17098.
Bizzozero, O.A., McGarry, J.F. and Lees, M.B. (1987) Autoacylation of myelin
proteolipid protein
with acyl-coenzyme
A. J. Biol. Chem. 262:13550-13557.
Perrone, N., Benowitz, L., Apostolides, P., Franck,E., Finklestein, S. Bizzozero,
O. (1989)
Protein fatty acid acylation in developing cortical neurons.
J. Neurochem. 52:1149-1155.
Bizzozero, O.A., Zuniga, G. And Lees, M.B. (1991) Fatty acid composition of
human myelin proteolipid
protein in peroxisomal disorders.
J. Neurochem. 56:872-878.
