Biomedical Sciences 507 – Advanced Molecular Biology
Semester: Fall
Time and Place: 2:15-3:45 pm, MWF, Domenici B116
Course Coordinator: Scott Ness, Dept. of Molecular Genetics and Microbiology
Optional Text: Molecular Biology of the Gene, Fifth Edition by Watson et. al. - available from Amazon.com
Participating Instructors:
Name | Office | Telephone | |
| Bryce Chackerian | BRF 320 | 272-0269 | bchackerian@salud.unm.edu |
| Scott Ness | CRF 121 | 272-9883 | ness@unm.edu |
| Mary Ann Osley | CRF 123 | 272-4839 | mosley@salud.unm.edu |
| Stephanie Ruby | CRTC 330 | 272-5830 | sruby@salud.unm.edu |
| Angela Wandinger-Ness | CRF 225 | 272-1459 | awandinger@salud.unm.edu |
| TA: Anita Quintana | CRF 121 | 272-3464 | amquintana@salud.unm.edu |
Course Description:
This course in advanced molecular biology is designed as a rigorous introduction to the topics, terminology, techniques, methodologies and approaches of modern molecular biology. The course serves as an introduction for first year graduate students and to help students make the transition from lecture-based, text book-oriented courses common in undergraduate training to independent learning organized around current research papers and seminars that are the hallmarks of advanced studies. The course has some lectures, but is focused on problem-based learning, with the latter organized around the understanding and analysis of current scientific papers. Students will take an active role in their own education by helping to identify and design learning issues that will be resolved in small group and in-class discussions. Grading will be based on in-class discussions and class participation, homework assignments, take-home problems and some exams.
BioMed 507 is an advanced course and is taught with the assumption that all students have had previous courses in biochemistry, molecular biology and genetics and that many have already had significant laboratory experience.
In addition, BioMed 507 is taught primarily as a discussion-based course, not as a typical lecture course. Participation in classroom discussions and student presentations is essential. Consequently, attendance is mandatory. There is no mechanism for making up discussion material or classes that are missed and no credit will be given for classes that are missed.
Course Description:
Date | Day | Instructor | Topic | Links |
| 24-Aug | M | Ness | Intro, Genes, Regulation | Info, Week1 |
| 26-Aug | W | Ness | Intro, Genes, Regulation | Homework1, |
| 28-Aug | F | Ness | Intro, Genes, Regulation | Homework 1 due, presentations |
| 31-Aug | M | Ness | Intro, Genes, Regulation | Week2, Homework2, Homework2_Instructions, Homework3 |
| 2-Sep | W | Ness | Intro, Genes, Regulation | Homeworks 2 and 3 due, Homework4 |
| 4-Sep | F | Ness | Intro, Genes, Regulation | Homework 4 due, presentations, Homework5 |
| 6-Sep Labor Day Holiday | M | --- | --- | |
| 9-Sep | W | Ness | Intro, Genes, Regulation | Homework 5 due, presentations |
| 11-Sep | F | Ness | Intro, Genes, Regulation | In class exam |
| 14-Sep | M | Osley | Chromatin, Modifications, Epigenetics | References, Class1, Homework1, Chromatin Primer |
| 16-Sep | W | Osley | Chromatin, Modifications, Epigenetics | Class2, Homework2 |
| 18-Sep | F | Osley | Chromatin, Modifications, Epigenetics | Class3, Remodel Review, Pol II Review |
| 21-Sep | M | Osley | Chromatin, Modifications, Epigenetics | Class4, Presentations, Background Readings |
| 23-Sep | W | Osley | Chromatin, Modifications, Epigenetics | Carrozza 2005, Li 2007, Whitehouse 2006, Whitehouse 2007 |
| 25-Sep | F | Osley | Chromatin, Modifications, Epigenetics | Class5 |
| 28-Sep | M | Osley | Chromatin, Modifications, Epigenetics | Class6 |
| 30-Sep | W | Osley | Chromatin, Modifications, Epigenetics | |
| 2-Oct | F | Osley | Chromatin, Modifications, Epigenetics | Exam Key |
| 5-Oct | M | Ruby | RNA Biology | |
| 7-Oct | W | Ruby | RNA Biology | |
| 9-Oct | F | Ruby | RNA Biology | |
| 12-Oct | M | Ruby | RNA Biology | |
| 14-Oct | W | Ruby | RNA Biology | |
| 16-Oct Fall Break | F | --- | --- | |
| 19-Oct | M | Ruby | RNA Biology | |
| 21-Oct | W | Ruby | RNA Biology | |
| 23-Oct | F | Ruby | RNA Biology | |
| 26-Oct | M | Chackerian | Virus Strategies | Article 1, Article 2, Article 3, Article 4, Lecture1 |
| 28-Oct | W | Chackerian | Virus Strategies | Lecture2 |
| 30-Oct | F | Chackerian | Virus Strategies | Lecture3 |
| 2-Nov | M | Chackerian | Virus Strategies | |
| 4-Nov | W | Chackerian | Virus Strategies | |
| 6-Nov | F | Chackerian | Virus Strategies | |
| 9-Nov | M | Wandinger-Ness | Unfolded Protein Response | Syllabus, Review 1, Review 2 |
| 11-Nov | W | Wandinger-Ness | Unfolded Protein Response | Article day 2, |
| 13-Nov | F | Wandinger-Ness | Unfolded Protein Response | Article day 3, |
| 16-Nov | M | Wandinger-Ness | Unfolded Protein Response | Article day 4, |
| 18-Nov | W | Wandinger-Ness | Unfolded Protein Response | Article day 5, |
| 20-Nov | F | Wandinger-Ness | Unfolded Protein Response | Article day 6, |
| 23-Nov | M | Ness and Osley | New Topics | Outline, Papers |
| 25-Nov | W | No class. Happy Thanksgiving | ||
| 27-Nov Thanksgiving | F | --- | --- | |
| 30-Nov | M | Ness and Osley | New Topics | |
| 2-Dec | W | Ness and Osley | New Topics | |
| 4-Dec | F | Ness and Osley | New Topics | |
| 7-Dec | M | Ness and Osley | New Topics | |
| 9-Dec | W | Ness and Osley | New Topics | |
| 11-Dec | F | Ness and Osley | New Topics |