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KUGR Genomics
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Bryce Chackerian, Ph.D.
Vojo Deretic, Ph.D.
Jeremy S. Edwards, Ph.D.
Hattie Gresham, Ph.D.
Carolyn Mold, Ph.D.
Scott A. Ness, Ph.D.
Jac A. Nickoloff, Ph.D.
Mary Ann Osley, Ph.D.
Michelle A. Ozbun, Ph.D.
Antonito Panganiban, Ph.D.
David Peabody, Ph.D.
Roger Radloff, Ph.D.
Robert L. Rubin, Ph.D.
Stephanie Ruby, Ph.D.
Cosette Wheeler, Ph.D.
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John P. O'Rourke Jr., Ph.D.
Isabelle Vergne, Ph.D.
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BioMed 507
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Albuquerque
New Mexico
UNM Health Sciences Cntr
UNM
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Department of Molecular Genetics and Microbiology
Carolyn Mold, Ph.D.
 Molecular Genetics and Microbiology
Univ. of New Mexico HSC
915 Camino de Salud NE
Albuquerque, NM 87131
Office: BMSB 351
Tel: (505) 272-5768
Fax: (505) 272-6029
e-mail: cmold@salud.unm.edu
Keywords: autoimmunity, complement, Fc receptors, innate immunity, C-reactive protein.
Research Interests:
Proteins of Innate immunity including complement, C-reactive protein and serum amyloid P component. The role of these proteins in the response to tissue damage, in systemic autoimmunity and in host defense against bacterial infection.
Recent Publications:
Bharadwaj, D., M-P. Stein, M. Volzer, C. Mold, and T.W. Du Clos. 1999. The major receptor for C-reactive protein on leukocytes is Fcγreceptor II. Journal of Experimental Medicine 190:585-590.
Stein, M-P., C. Mold, and T.W. Du Clos. 2000. C-reactive protein binding to murine leukocytes requires Fcγ receptors. Journal of Immunology. 164:1514-1520.
Stein, M-P., J.C. Edberg, R.P. Kimberly, E.K. Mangan, D. Bharadwaj, C. Mold, and T.W. Du Clos. 2000. C-reactive protein binding to FcgRIIa on human monocytes and neutrophils is allele specific. Journal of Clinical Investigation. 105:369-376.
Mold, C., H. Gresham, and T.W. Du Clos. 2001. Serum amyloid P component (SAP) and C-reactive protein (CRP) mediate phagocytosis through murine Fcγ receptors. Journal of Immunology 166:1200-1205.
Mold, C., B. Rodic-Polic, T.W. Du Clos. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fcγ receptors. Journal of Immunology 169:7019-7025.
Mold, C., R. Baca, T.W. Du Clos. 2002. Serum amyloid P component and C-reactive protein opsonize apoptotic cells for phagocytosis through Fcγ receptors. Journal of Autoimmunity 19:147-154.
Mold, C., W. Rodriguez, B. Rodic-Polic, and T.W. Du Clos. 2002. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fcγ receptors. Journal of Immunology 169:7109-7125.
Rodriguez, W., C. Mold, M. Kataranovski, J. Hutt, LL. Marnell, and T.W. Du Clos. 2005. C-reactive protein reverses ongoing lupus nephritis. Arthritis and Rheumatism, 52:642-650.
Bang, R., L.L. Marnell, C. Mold, M.P. Stein, K. Du Clos, C. Chivington-Buck, and T.W. Du Clos. 2005. Overlap of Human FcγRI, FcγRIIa, and C1q binding sites in C-reactive protein as determined by site-directed mutagenesis. Journal of Biological Chemistry, 280:25095-25102.
Rodriguez, W., C. Mold, L.L. Marnell, J. Hutt, G. J. Silverman, D. Tran, and T. W. Du Clos. 2006. Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein. Arthritis and Rheumatism, 54:325-335.
Mold, C. and T.W. Du Clos. 2006. C-reactive protein increases cytokine responses to Streptococcus pneumoniae through interactions with Fcγ receptors. Journal of Immunology, 176:7598-7604.
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