Carolyn Mold, Ph.D.

Molecular Genetics and Microbiology
MSC08 4660
1 University of New Mexico
Albuquerque, NM 87131-0001
 
Office: BMSB 351
Tel: (505) 272-5768
Fax: (505) 272-6029
E-mail: cmold@salud.unm.edu

Keywords: autoimmunity, complement, Fc receptors, innate immunity, C-reactive protein.

Research Interests

Proteins of Innate immunity including complement, C-reactive protein and serum amyloid P component. The role of these proteins in the response to tissue damage, in systemic autoimmunity and in host defense against bacterial infection.

Selected Publications

Stein, M-P., J.C. Edberg, R.P. Kimberly, E.K. Mangan, D. Bharadwaj, C. Mold, and T.W. Du Clos. 2000. C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele specific. Journal of Clinical Investigation. 105:369-376.

Mold, C., B. Rodic-Polic, T.W. Du Clos. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fcγ receptors. Journal of Immunology 169:7019-7025.

Mold, C., R. Baca, T.W. Du Clos. 2002. Serum amyloid P component and C-reactive protein opsonize apoptotic cells for phagocytosis through Fcγ receptors. Journal of Autoimmunity 19:147-154.

Mold, C, W. Rodriguez, B. Rodic-Polic, and T.W. Du Clos. 2002. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fcγ receptors. Journal of Immunology 169:7109-7125.

Rodriguez, W., C. Mold, M. Kataranovski, J. Hutt, LL. Marnell, and T.W. Du Clos. 2005. C-reactive protein reverses ongoing lupus nephritis. Arthritis and Rheumatism, 52:642-650.

Bang, R., L.L. Marnell, C. Mold, M.P. Stein, K. Du Clos, C. Chivington-Buck, and T.W. Du Clos. 2005. Overlap of Human FcγRI, FcγRIIa, and C1q binding sites in C-reactive protein as determined by site-directed mutagenesis. Journal of Biological Chemistry, 280:25095-25102.

Rodriguez, W., C. Mold, L.L. Marnell, J. Hutt, G. J. Silverman, D. Tran, and T. W. Du Clos. 2006. Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein. Arthritis and Rheumatism, 54:325-335.

Mold, C. and T.W. Du Clos. 2006. C-reactive protein increases cytokine responses to Streptococcus pneumoniae through interactions with Fcγ receptors. Journal of Immunology, 176:7598-7604.

Rodriguez, W., C. Mold, M. Kataranovski, J.A. Hutt, L.L. Marnell, J.S. Verbeek, and T.W. Du Clos. 2007. C-reactive protein-mediated suppression of nephrotoxic nephritis: Role of macrophages, complement and Fcγ receptors. Journal of Immunology, 178:530-538.

Thomas-Rudolph, D., T.W. Du Clos, C.M. Snapper, and C. Mold. 2007. C-reactive protein enhances immunity to Streptococcus pneumoniae by targeting uptake to FcγR on dendritic cells. Journal of Immunology, 178:7283-7291.