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KUGR Genomics
Positions Open
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Bryce Chackerian, Ph.D.
Vojo Deretic, Ph.D.
Jeremy S. Edwards, Ph.D.
Hattie Gresham, Ph.D.
Carolyn Mold, Ph.D.
Scott A. Ness, Ph.D.
Jac A. Nickoloff, Ph.D.
Mary Ann Osley, Ph.D.
Michelle A. Ozbun, Ph.D.
Antonito Panganiban, Ph.D.
David Peabody, Ph.D.
Roger Radloff, Ph.D.
Robert L. Rubin, Ph.D.
Stephanie Ruby, Ph.D.
Cosette Wheeler, Ph.D.
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John P. O'Rourke Jr., Ph.D.
Isabelle Vergne, Ph.D.
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BioMed 507
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Albuquerque
New Mexico
UNM Health Sciences Cntr
UNM
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Department of Molecular Genetics and Microbiology
Hattie D. Gresham, Ph.D.
 Molecular Genetics and Microbiology
University of New Mexico HSC
915 Camino de Salud NE
Albuquerque, NM 87131
Office: BMCB 382A
Tel: (505) 272-5764
Fax: (505) 272-6029
E-mail: hgresham@salud.unm.edu
Keywords: phagocytosis, Staphylococcus aureus, negative regulation of signal transduction
Research Interests
My research program studies the role of phagocytes, particularly neutrophils, in host defense against infectious diseases. My current work is focused around two funded projects - one examining how the gram positive bacterial pathogen, Staphylococcus aureus, escapes killing by neutrophils and macrophages and another examining the role of CD47 and SIRPalpha in the negative regulation of phagocyte function. Phagocytes are a critical component of innate immunity and understanding how pathogens coopt and evade innate immunity will be essential to the development of new treatments for Staphylococcal infection. In addition, understanding the molecular mechanisms that inhibit phagocyte activation may have importance for intervening in many human diseases, including autoimmune disease, cancer, and infection.
For information about post-doc positions in the Gresham lab, see Job Opportunities.
Recent Publications
Rothfork, J., Dessus-Babus, S., Van Wamel, W., Cheung, A., and Gresham, H. Fibrinogen depletion attenuates Staphylococcus aureus infection by preventing density-dependent virulence gene upregulation. J. Immunol. 171:5389-5395, 2003.
Oldenborg, P., Zheleznyak, A., Fang, Y.., Lagenauer, C., Gresham, H., and Lindberg. F. 2000. Role of CD47 as a marker of self on red blood cells. Science. 288: 2051-2054.
Gresham, H. D., J. H. Lowrance, T. E. Caver, B. S. Wilson, A. L. Cheung, F. P. Lindberg. 2000. Survival of Staphylococcus aureus inside neutrophils contributes to infection. J. Immunol. 164:3713-22.
Gresham, H. D., B. M. Dale, J. W. Potter, P. W. Chang, C. M. Vines, C. A. Lowell, C. F. Lagenaur, and C. L. Willman. 2000. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J. Exp. Med. 191:515-28.
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