Hattie D. Gresham, Ph.D.

Research Microbiologist
NMVAHCS
Adjunct Professor of Infectious Diseases
University of New Mexico
phone: 505-256-2810
FAX: 505-256-2877
E-mail: hgresham@salud.unm.edu

Keywords: phagocytosis, Staphylococcus aureus, negative regulation of signal transduction.

Research Interests

My research program studies the role of phagocytes, particularly neutrophils, in host defense against infectious diseases. My current work is focused around two funded projects - one examining how the gram positive bacterial pathogen, Staphylococcus aureus, escapes killing by neutrophils and macrophages and another examining the role of CD47 and SIRPalpha in the negative regulation of phagocyte function. Phagocytes are a critical component of innate immunity and understanding how pathogens coopt and evade innate immunity will be essential to the development of new treatments for Staphylococcal infection. In addition, understanding the molecular mechanisms that inhibit phagocyte activation may have importance for intervening in many human diseases, including autoimmune disease, cancer, and infection.

Selected Publications

Peterson, M.M., Mack, J.L., Hall, P.R., Alsup, A.A., Alexander, S.M., Sully, E.K., Sawires, Y.S., Cheung, A.L., Otto, M., and Gresham, H.D. (2008). Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection. Cell Host Microbe 4, 555-566.

Rothfork, J.M., Timmins, G.S., Harris, M.N., Chen, X., Lusis, A.J., Otto, M., Cheung, A.L., and Gresham, H.D. (2004). Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc Natl Acad Sci U S A 101, 13867-13872.

Rothfork, J.M., Dessus-Babus, S., Van Wamel, W.J., Cheung, A.L., and Gresham, H.D. (2003). Fibrinogen depletion attenuates Staphyloccocus aureus infection by preventing density-dependent virulence gene up-regulation. J Immunol 171, 5389-5395.

Oldenborg, P.A., Gresham, H.D., Chen, Y., Izui, S., and Lindberg, F.P. (2002). Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Blood 99, 3500-3504.

Vines, C.M., Potter, J.W., Xu, Y., Geahlen, R.L., Costello, P.S., Tybulewicz, V.L., Lowell, C.A., Chang, P.W., Gresham, H.D., and Willman, C.L. (2001). Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15, 507-519.

Oldenborg, P.A., Gresham, H.D., and Lindberg, F.P. (2001). CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. J Exp Med 193, 855-862.

Mold, C., Gresham, H.D., and Du Clos, T.W. (2001). Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs. J Immunol 166, 1200-1205.

Oldenborg, P.A., Zheleznyak, A., Fang, Y.F., Lagenaur, C.F., Gresham, H.D., and Lindberg, F.P. (2000). Role of CD47 as a marker of self on red blood cells. Science 288, 2051-2054.

Gresham, H.D., Lowrance, J.H., Caver, T.E., Wilson, B.S., Cheung, A.L., and Lindberg, F.P. (2000). Survival of Staphylococcus aureus inside neutrophils contributes to infection. J Immunol 164, 3713-3722.

Gresham, H.D., Dale, B.M., Potter, J.W., Chang, P.W., Vines, C.M., Lowell, C.A., Lagenaur, C.F., and Willman, C.L. (2000). Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J Exp Med 191, 515-528.