Isabelle Vergne, Ph.D.

Molecular Genetics and Microbiology
MSC08 4660
1 University of New Mexico
Albuquerque, NM 87131-0001
 
Office: BMSB 383B
Tel: (505) 272-9579
Fax: (505) 272-6029
E-mail: ivergne@salud.unm.edu

Keywords: Mycobacterium tuberculosis, macrophages, phagosome maturation, lipids, autophagy.

Research Interests

The focus of my research is to understand the mechanisms of phagolysosome biogenesis and the arrest of this process by Mycobacterium tuberculosis and its products. My second project focuses on autophagy, a cytoplasmic degradation pathway that eliminates cytosolic protein and organelles, and its role in innate immunity against intracellular pathogens.

Information about post-doctoral positions.

Selected Publications

Kyei G., Vergne I., Chua J., Roberts E., Harris J., Junutula JR., V. Deretic. 2006. Rab14 Is Critical for Maintenance of Mycobacterium tuberculosis Phagosome Maturation Arrest. Embo J. 25:5250-9.

Deretic V., Singh S., Master S., Kyei G., Davis A., Naylor J., de Haro S., Harris J., Delgado M., Roberts E., I. Vergne. 2007. Phosphoinositides in phagolysosome and autophagosome biogenesis. Biochem. Soc. Symp. 74:141-148. (Review)

A. S. Davis, I. Vergne, S. Master, G. B. Kyei, J. Chua and V. Deretic. 2008. Mechanism of Inducible Nitric Oxide Synthase Exclusion from Mycobacterial Phagosomes. Plos Pathogens. 3:1887-1894.

Liang C., Lee JS., Inn KS., Gack MU., Li Q., Roberts EA., Vergne I., Deretic V., Feng P., Akazawa C., Jung JU. 2008. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat.Cell.Biol. 10:776-87.

Delgado M, Singh S, De Haro S, Master S, Ponpuak M, Dinkins C, Ornatowski W, Vergne I, Deretic V. 2009. Autophagy and pattern recognition receptors in innate immunity. Immunol Rev. 227:189-202. (Review)

Vergne I, Roberts E, Elmaoued RA, Tosch V, Delgado MA, Proikas-Cezanne T, Laporte J, Deretic V. 2009. Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy. Embo J. (in press)

Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, Federico M, Panganiban A, Vergne I, Deretic V. 2009. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yield in macrophages. J. Cell. Biol. (in press)