• MSC10 5615
• 1 University of New Mexico
• Albuquerque, NM 87131-0001
• Clinic Appointments: 505-272-9494
• Phone: 505-272-3401
• Fax: 505-272-6091

Department of Neurosurgery

Research: Edwin M. Nemoto, PhD

• In stroke patients with occlusive vascular disease: We are studying the relative accuracy and concordance between qualitative and quantitative measurements of hemodynamic compromise by cerebrovascular reserve (CVR) and oxygen extraction fraction (OEF) using positron emission tomography (PET). Accurate identification of hemodynamic compromise in these patients is important because if present, they are at high risk for recurrent stroke and may benefit from bypass surgery.
• In rats subjected to acute stroke using magnetic resonance imaging (MRI) we are tracking brain tissue ischemic transitions using dual parameter voxel analysis of quantitative apparent diffusion coefficient (ADC) by diffusion tensor imaging (DTI) and cerebral blood flow (CBF) by continuous arterial spin labeling (CASL). The accurate identification of the ischemic penumbra is important because the basic premise of neuroprotection in acute stroke or traumatic brain injury, is the presence of salvageable tissue. These methods are being applied in animal models of stroke and traumatic brain injury.
• In rats, we are investigating the concept of precapillary shunt flow through thorofare channels as a mechanism of hyperemia and brain edema with raised intracranial pressure by two photon laser microscopy (2PLM) measurements of red blood cell flow velocities combined with tissue blood flow by laser Doppler oxygenation by NADH fluorescence. The mechanisms involved in the development of brain edema and its relationship to raised intracranial pressure are poorly understood.