Cytometry Laboratory
Bruce S. Edwards Ph.D.
Current Research
Current Research
Bruce S. Edwards. Ph.D. is a Research Associate Professor of Pathology and Scientific
Coordinator of the Shared Flow Cytometry Resource at the University of New Mexico. He lists
more than 50 publications describing research studies in cellular immunology, signal transduction
and cell adhesion. Currently funded research includes studies of cell adhesion mechanisms by
which eosinophils migrate into lungs to promote asthma and resolution of processes governing
leukocyte integrin-dependent cell adhesion. He is also active in the development of hardware
and software systems to improve flow cytometry technology. Recent examples include NIH funded
development of the Plug Flow and HypercytTM Cytometry systems for automated high throughput
analysis of cells and bio-particles.
Selected Publications:
- Bennett, T. A., B. S. Edwards, L. A. Sklar, and S. Rogelj. 2000. Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytes. J Immunol 164:4120.
- Burchiel, S. W., B. S. Edwards, F. W. Kuckuck, F. T. Lauer, E. R. Prossnitz, J. T. Ransom, and L. A. Sklar. 2000. Analysis of free intracellular calcium by flow cytometry: multiparameter and pharmacologic applications. Methods 21:221.
- Chigaev, A., A. M. Blenc, J. V. Braaten, N. Kumaraswamy, C. L. Kepley, R. P. Andrews, J. M. Oliver, B. S. Edwards, E. R. Prossnitz, R. S. Larson, and L. A. Sklar. 2001. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J Biol Chem 276:48670.
- Edwards, B. S., M. S. Curry, H. Tsuji, D. Brown, R. S. Larson, and L. A. Sklar. 2000. Expression of P-selectin at low site density promotes selective attachment of eosinophils over neutrophils. J Immunol 165:404.
- Edwards, B. S., F. W. Kuckuck, E. R. Prossnitz, J. T. Ransom, and L. A. Sklar. 2001. HTPS flow cytometry: a novel platform for automated high throughput drug discovery and characterization. J Biomol Screen 6:83.
- Edwards, B. S., F. W. Kuckuck, E. R. Prossnitz, A. Okun, J. T. Ransom, and L. A. Sklar. 2001. Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology. Cytometry 43:211.
- Jackson, W. C., T. A. Bennett, B. S. Edwards, E. Prossnitz, G. P. Lopez, and L. A. Sklar. 2002. Performance of in-line microfluidic mixers in laminar flow for high-throughput flow cytometry. Biotechniques 33:220.
- Jackson, W. C., F. Kuckuck, B. S. Edwards, A. Mammoli, C. M. Gallegos, G. P. Lopez, T. Buranda, and L. A. Sklar. 2002. Mixing small volumes for continuous high-throughput flow cytometry: Performance of a mixing Y and peristaltic sample delivery. Cytometry 47:183.
- Kuckuck, F. W., B. S. Edwards, and L. A. Sklar. 2001. High throughput flow cytometry. Cytometry 44:83.
- Sklar, L. A., B. S. Edwards, S. W. Graves, J. P. Nolan, and E. R. Prossnitz. 2002. Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annu Rev Biophys Biomol Struct 31:97.
