Larson Laboratory
Richard S. Larson M.D., Ph.D.
Associate Professor
Current Research
Current Research
Richard S. Larson has research interest that include biochemical mechanisms of cell
adhesion and new drug discovery. His lab studies mechanisms of leukocyte localization.
Using a combination of computational and biologic techniques, we have developed a number
of drug candidates for use in ischemia-reperfusion injury and Sin Nombre Virus infection.
He is the recipient of the College of American Pathology Lansky Award for his leadership
in and contribution to the practice of pathology, UNM Regents Lecture ship for contribution
to UNM, and American Cancer Society Designated National Investigator for the Coaches against
Cancer and Hoops for Lymphoma/Leukemia.
Selected Publications:
- Winter SS, Sweatman JJ, Shuster JJ, Link MP, Amylon M, Pullen J, Camitta BM, LARSON RS. Bone Marrow Stroma-Supported Culture of T-lineage Acute Lymphoblastic Leukemic Cells Predicts Treatment Outcome in Children: A Pediatric Oncology Group Study. Leukemia 16:1121-1126, 2002.
- Sillerud L, Burks, E, Brown DC, LARSON RS. NMR-derived Model of Interconverting Conformations of an ICAM-1 Inhibitory cyclic-nonapeptide. J Pept Research,62:97-116, 2003
- Merchant SH, Gurule DM, LARSON RS. Amelioration of Ischemia-Reperfusion Injury with Cyclic Peptide Blockade of ICAM-1. Am J Phys-Heart and Circ 284:H1260-H1268, 2003.
- Churchwell CJ, Rintoul MD, Martin S, Visco DP, Kotu A, Brown DC, Sillerud LO, LARSON RS. The Signature Molecule Descriptor: Inverse quantitativge structure-actvity relationship of ICAM-1 inhibitory peptides. J Mol Model and Design 22:263-273, 2004.
- LARSON RS, Brown DC, Ye C, Hjelle B. Peptide antagonists of Sin Nombre virus entry through the β3 integrin receptor. JVirology 79.7319-7326,2005.
Recent Review:
Sillerud, L, LARSON RS. Design and Structure of Peptide Antagonists and Peptidomimetics, Current Protein and Peptide Science 6:151-169,2005.
Book:
LARSON RS (ed). Bioinformatics and Drug Design. Human Press: London, 2005.
