Peripheral blood smear from a 2-year old boy demonstrating the characteristic inclusions found in Chediak-Higashi Syndrome. Inherited in an autosomal recessive fashion, mutations localized in chromosome 1 are associated with defects in lysosome and vesicle fusion that result in partial albinism and functional defects in WBC and platelets. An individual harboring such mutations is at increased risk for neuropathy, recurrent infections, lymphoma and leukemia. Photographs: John K. Scariano, University of New Mexico Department of Pathology