Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity
island mutant induces protective immunity against homotypic and
heterotypic challenge
By Yu Conga, Jieh-Juen Yua, M. Neal Guentzela, Michael T. Bertonb, Janakiram Seshua,
Karl E. Klosea, Bernard P. Arulanandama
Vaccine, 27 (41), p.5554-5561, Sep 2009
...cells were infected with KKF235 or its parental...strain (U112), using a MOI of 10.
The number...challenged i.n. with 104, 105, 106or...organs after i.n. vaccination. BALB/c mice were challenged
with 106CFU of KKF235 and...c mice received a single immunizing...
University leads microscopic battle vs. bioweapons
By Sue Vorenberg, Scripps Howard News Service, November 20, 2005
Tularemia Vaccine Contracts Among New NIAID Biodefense Awards
NIH Press Release, October 3, 2005
Construction of targeted insertion mutations in
Francisella tularensis
subsp. novcida
Jirong Liu, Xhavit Zogaj, Jeffrey R. Barker, and Karl
E. Klose
University of Texas San Antonio, San Antonio, TX, USA
