Development & Stem Cell Biology
Developmental studies focus on: 1) regulation of the
embryonic cell cycle and how embryonic regulatory mechanisms are reactivated
in cancer cells; 2) connective tissue growth factor as a regulator of
cell proliferation and differentiation; 3) development of the mammary
gland, an organ that undergoes branching morphogenesis in response to
sex hormones, including cell-cell and cell-matrix interactions, remodeling
of the ECM, and hormone-dependent growth; and the 4) pathophysiology of
fetal alcohol syndrome, including the mechanisms involved in neuronal
circuit maturation and synapse refinement during braindevelopment, and
the impact of alcohol on these processes.
Neural stem cell biologists study the role of neural transmitters and
genetic and epigenetic mechanisms that regulate neural stem cells, as
well as the implications of this regulation in postnatal neural development,
plasticity and repair in the adult nervous system, and brain tumor formation.
Studies on hematopoietic stem cells (HSCs) focus on the requirement for
c-Myb in the development of all blood cell lineages, including the modifications
to c-Myb protein that alter its activity and allow it to regulate the
development of specific cell lineages.
Lee Anna Cunningham,
PhD
Mechanisms of cell death, plasticity and repair in Parkinson's disease
and stroke
Gary
Grotendorst, PhD
Biology of connective tissue growth factor (CTGF) as a regulator of cell
proliferation and differentiation
Rebecca Hartley,
PhD
Post-transcriptional regulation of the cell cycle in cancer and embryogenesis
Helen Hathaway, PhD
Mammary gland development and breast cancer
Scott Ness, PhD
Stem cells, oncogenes, signaling and the regulation of transcription,
differentiation and cell cycle
C. Fernando Valenzuela,
MD/PhD
Regulation of synaptic transmission during development, and how teratogenic
drugs of abuse, such as alcohol, affect this process
James Wallace, PhD
The role of neurotransmitters in regulating neural stem cell development
and differentiation
Xinyu Zhao, PhD
To understand molecular regulations of postnatal neurogenesis and neuronal
maturation for brain
repair
Ben Walker, PhD
Effects of hypoxia on vascular regulation
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