Molecular & Biochemical Basis of Disease
Research in this Area focuses on understanding human
diseases using cell, biochemical and molecular techniques to address the
basic molecular mechanisms underlying the disease state. A primary goal
is to bridge the basic sciences with clinical applications in order to
translate discoveries at the molecular level to successful therapeutics.
Investigators in the Area of Molecular and Biochemical Basis of Disease
address five fundamental questions in biomedical research:
What is the problem (disease)?
How did it happen (mechanism)?
What is the cause (diagnosis)?
What can be done (treatment)?
Will it happen again (prognosis)?
Andrea Allan, PhD
Prenatal drug and environmental exposure models; neural control of cognition;
learning and memory
William
Anderson, PhD
Bioconjugate chemistry, biosensors, membrane bound enzyme arrays, biomedical
education
David Bear, PhD
Regulation of mRNA biosynthesis and transport in muscular dystrophies
and muscle cell cancers; novel electron microscopy techniques to study
gene expression
Marco Bisoffi,
PhD
Mechanisms of cancer metastasis, androgen independence in prostate cancer,
telomere biology
Oscar Bizzozero,
PhD
Molecular mechanisms of tissue injury in multiple sclerosis and other
demyelinating disorders
Susan
E. Boggs, PhD
Lung epithelial cellular responses to tobacco smoke
Laura Gonzalez
Bosc, PhD
Transcriptional regulation of vascular smooth muscle phenotype
Bryce Chackerian, PhD
Interactions between virus particles and the immune system
John Connor, PhD
Ca2+ and related second control of normal and degenerative responses in
brain neurons
Lee Anna Cunningham,
PhD
Mechanisms of cell death, plasticity and repair in Parkinson's disease
and stroke
Dusanka Deretic,
PhD
Biosynthesis, sorting and post-Golgi trafficking of rhodopsin to the rod
outer segments (ROS)
Jeremy Edwards, PhD
Spatial temporal modeling, epidermal growth factor receptor, functional
genomics technologies, sequencing
Linda
Felton, PhD
Drug delivery systems and pharmaceutics
Robert H. Glew,
PhD
Maternal/child health problems in sub-Saharan Africa, fatty acid metabolism,
sickle cell anemia
Gary
Grotendorst, PhD
Biology of connective tissue growth factor (CTGF) as a regulator of cell
proliferation and differentiation
Chien-An Andy
Hu, PhD
Programmed celld eath (apoptosis and autophagy) in cancer and human genetic
disease, molecular enzymology of proline metabolism
Adriana
Kajon, PhD
Molecular biology and evolution of respiratory adenoviruses
Nancy Kanagy, PhD
Study of the mechanisms leading to altered vascular smooth muscle and
endothelial cell physiology in animal models of hypertension and sleep
apnea.
Craig
Marcus, PhD
Role of Cytochromes P450 in disease, cancer, and toxicology.
Paul McGuire, PhD
The role of extracellular proteinases and growth factors in the regulation
of ocular angiogenesis and vascular permeability.
Charlotte
Mobarak, PhD
Applications of proteomics to cancer research, cancer marker discovery
Carolyn Mold, PhD
Acute phase proteins particularly C-reactive protein in the regulation
of inflammation and autoimmunity through interactions with Fc receptors
and induction of cytokines.
Jac Nickoloff, PhD
Molecular mechanisms of eukaryotic DNA repair with emphasis on DNA double-strand
break repair and its roles in maintaining genome stability and tumor suppression.
Tudor Oprea,
MD/PhD
Drug discovery, cheminformatics, molecular modeling, virtual screening
Robert A.
Orlando, PhD
Obesity and cardiovascular disease, LDL receptor family, proteoglycans,
Alzheimer's disease
Michelle Ozbun,
PhD
Human papillomaviruses, animal papillomaviruses, cervical cancer, skin
cancer, epithelial biology, cancer biology, virology
Karlett J. Parra, Ph.D.
Metabolic/nutritional control of proton transport/cellular pH by V-type
ATPase pumps, V-ATPase molecular motors structure/function/regulation.
Nora Perrone-Bizzozero,
PhD
Gene expression control during brain development; synaptic plasticity
and neurodevelopmental disorders
Steven
Peterson, PhD
Mechanisms of neuropathology in experimental models of seizures and epilepsy
Eric Prossnitz,
PhD
The Prossnitz lab focuses on cellular signaling mechanisms initiated by
G protein-coupled receptors.
Robert L. Rubin, PhD
The main focus of the laboratory is on systemic autoimmunity and how environmental
factors such as drugs and toxicants influence development of autoreactive
T cells.
Daniel Savage, PhD
Impact of ethanol and other environmental stressors on brain development
and function
Laurel Sillerud,
PhD
Prostate cancer, metabolic regulation in tumors, biomedical NMR, cancer
metastasis
Yohannes
Tesfaigzi, PhD
Mechanisms underlying the proper regulation of cell numbers in airway
epithelia following inflammatory injury and their relation to chronic
diseases and cancers of the lung
C. Fernando Valenzuela,
MD/PhD
Regulation of synaptic transmission during development, and how teratogenic
drugs of abuse, such as alcohol, affect this process
David L. Vanderjagt,
PhD
Structure-based drug design, molecular modeling, cancer research, diabetes
research
Dorothy Vanderjagt,
PhD
Maternal/child health in sub-Saharan Africa, nutrition assessment, sickle
cell anemia, body composition
Mary
K. Walker, PhD
Study the molecular mechanisms of the Ah receptor in cardiovascular physiology
and disease
Angela
Wandinger-Ness, PhD
Stem cells, kidney cell biology and mechanisms of protein trafficking
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