Molecular Genetics & Genomics
Changes in signaling pathways and transcriptional regulation
are the basis for all important cellular and disease processes including
apoptosis, differentiation, proliferation, senescence and development.
The faculty in this Research Area study these processes at the cellular
and molecular levels and strive to understand how changes in the interactions
between proteins or between proteins and nucleic acids are translated
into biological differences such as changes in the cell cycle, differences
in gene expression, altered immune response or increased resistance to
chemotherapeutic agents. These studies touch on all aspects of biomedical
sciences, from the mechanisms of disease to the molecular basis of neural
cell function to the identification of novel therapeutics for the treatment
of cancer, diabetes, genetic diseases or infections.
Steve
Belinsky, PhD
Role of gene promoter hypermethylation lung cancer and use as a biomarker
for early detection
Susan
E. Boggs, PhD
Lung epithelial cellular responses to tobacco smoke
Laura Gonzalez
Bosc, PhD
Transcriptional regulation of vascular smooth muscle phenotype
Jeffrey
K. Griffith, PhD
Telomere biology, genetic polymorphisms and chromosome structure in cancer
Adriana
Kajon, PhD
Molecular biology and evolution of respiratory adenoviruses
Richard
Larson, MD/PhD
Cell adhesion and ligand design in the application to disease diagnosis,
biosensor design and
imaging agent development
Scott Ness, PhD
Stem cells, oncogenes, signaling and the regulation of transcription,
differentiation and cell cycle
Jac Nickoloff, PhD
Molecular mechanisms of eukaryotic DNA repair with emphasis on DNA double-strand
break repair
and its roles in maintaining genome stability and tumor suppression.
Mary Ann Osley,
PhD
Histone modifications and the regulation of gene expression and DNA damage
repair
Karlett J. Parra, Ph.D.
Metabolic/nutritional control of proton transport/cellular pH by V-type
ATPase pumps, V-ATPase molecular motors structure/function/regulation
David Peabody, PhD
RNA-protein interactions, translational regulation, virus assembly
Nora Perrone-Bizzozero,
PhD
Gene expression control during brain development; synaptic plasticity
and neurodevelopmental disorders
Stephanie Ruby, PhD
RNA splicing, snRNPs, DEAD-box proteins, spliceosome, DNA-damage response,
cancer biology, genomics
Todd A. Thompson, PhD
Investigate the molecular pathways in breast and prostate cancer development,
prevention, and treatment.
Dale
Walker, DVM
Molecular Genetics & Genomics, Evaluation of biomarkers of early toxic,
genetic, and/or carcinogenic changes in human and animal tissues, with
special emphasis upon the effects of exposure of lung tissue to low doses
of chemicals or ionizing radiation
Julie
Wilder, PhD
Genetic regulation of inflammatory responses to allergens and infections
agents, and understanding the development and consequences of immune responses
in the lungs
Thomas
Williams, PhD
Genetics of the MHC in human and non-human primates
Cheryl
Willman, MD
Genomics and genetics of acute leukemia; genomics for molecular classification,
risk assessment, and target identification
Michael Wilson, PhD
Molecular mechanisms of neurotransmission and its impact on brain development
and behavioral maturation
Xinyu Zhao, PhD
To understand molecular regulations of postnatal neurogenesis and neuronal
maturation for brain repair
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