Toxicology & Pharmacology
Toxicology and Pharmacology are two closely related disciplines.
Pharmacology focuses on the study of the effects of chemicals (including
drugs) on living systems, but primarily the beneficial or therapeutic
effects. Toxicology focuses on the study of the adverse effects of chemicals,
drugs and other environmental insults on living systems. Many of the faculty
working in this area investigate various mechanisms of Molecular and Environmental
Disease and are members of the the NIEHS-funded UNM Center for Environmental
Health and/or COBRE: Center of Biomedical Research Excellence: Integrative
Program in CNS Pathophysiology Research. Research interests of the faculty
working in this area utilize exciting multidisciplinary approaches and
state-of-the-art molecular, cellular, and physiological techniques to
study problems of environmental toxicology, chemical carcinogenesis, signal
transduction pathways, radical- mediated cell damage, immunotoxicology,
neurotoxicology, metabolism and bioactivation of chemical toxicants, pharmacogenomics
and new approaches to drug discovery, drug design and drug delivery.
Edward
G. Barrett, PhD
Fetal and infant immune maturation
Janet
Benson, PhD/DABT
Toxicological evaluations of single compounds and complex mixtures of
occupational and environmental concern
Oscar Bizzozero,
PhD
Molecular mechanisms of tissue injury in multiple sclerosis and other
demyelinating disorders
Scott
Burchiel, PhD
Immunotoxicity and carcinogenicity of environmental agents
Kevin Caldwell,
PhD
Signal transduction mechanisms underlying learning and memory
Matthew
Campen, PhD
How the cardiovascular system may become impaired as a result of insults
to the respiratory system
Yung-Sung
Cheng, PhD
Aerosol drug delivery; the design and test of air sampling instruments;
deposition in the respiratory
tract; air quality of ambient, occupational and indoor environments; measurement
of radon and
radon progeny; inhalation toxicology
Kelly
Dix, PhD/DABT
Preclinical drug development, xenobiotic metabolism and pharmacokinetics
Linda
Felton, PhD
Drug delivery systems and pharmaceutics
Changjian Feng, PhD
Structure/function and reaction mechanism of nitric oxide synthase
Donald
Godwin, PhD
Development and testing of novel sunscreen formulations to prevent skin
cancer
Laurie
Hudson, PhD
Signal transduction pathways regulating functional and phenotypic plasticity
in normal tissue and tumor metastasis
Jim Liu,
PhD
Free radical and oxidative stress in disease development, including carcinogenesis
and brain injury.
Craig
Marcus, PhD
Role of Cytochromes P450 in disease, cancer, and toxicology.
Joe
L. Mauderly, DVM
Health effects of air pollution
Jacob
McDonald, PhD
Implementation of analytical chemistry and aerosol science to address
questions of environmental relevance
Tudor Oprea,
MD/PhD
Drug discovery, cheminformatics, molecular modeling, virtual screening
Steven
Peterson, PhD
Mechanisms of neuropathology in experimental models of seizures and epilepsy
Matthew
Reed, PhD/DABT
Toxicology of inhaled toxicants and chemical and biochemical toxicology
Robert L. Rubin, PhD
The main focus of the laboratory is on systemic autoimmunity and how environmental
factors such as drugs and toxicants influence development of autoreactive
T cells.
Linda Saland, PhD
The effects of ethanol on brain opiate receptor expression and function
Daniel Savage, PhD
Impact of ethanol and other environmental stressors on brain development
and function
Bobby
Scott, PhD
Mechanisms-based modeling of low-dose radiation and chemical-induced stochastic
effects(mutations, apoptosis, neoplastic transformation)
JeanClare
Seagrave, PhD
Mechanisms of health effects of inhaled materials including air pollution
and cigarette smoke
C. William Shuttleworth,
PhD
Mechanisms underlying degenerative calcium signaling in central neurons
Hugh D.
C. Smyth, PhD
Drug delivery and pharmaceutics
Mohan
Sopori, PhD
The immunosuppresive and anti-inflammatory properties of nicotine are
mediated through its direct interaction with immune cells and indirectly
through the sympathetic autonomic nervous system
Todd
A. Thompson, PhD
Investigate the molecular pathways in breast and prostate cancer development,
prevention, and treatment.
Graham
Timmins, PhD
Investigate the role of UV-induced radicals in melanoma; drug radicals
in antibiotic action
C. Fernando Valenzuela,
MD/PhD
Regulation of synaptic transmission during development, and how teratogenic
drugs of abuse, such as alcohol, affect this process
Dale
Walker, DVM
Evaluation of biomarkers of early toxic, genetic, and/or carcinogenic
changes in human and animal tissues, with special emphasis upon the effects
of exposure of lung tissue to low doses of chemicals or ionizing radiation
Mary
K. Walker, PhD
Study the molecular mechanisms of the Ah receptor in cardiovascular physiology
and disease
Vernon
Walker, DVM/PhD
The identification and validation of biological markers that are suitable
for investigating genotoxic mechanisms, determining human exposures, and
evaluating human cancer risks associated with exposure to chemicals in
the environment or as a consequence of medical therapy
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