Anupam Basu, Ph.D.

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Research interests:
During the progression of diabetes, dysfunction of several organs occurs. These include hypertension and cardiac complications, renal complications or nephropathy and vision problems or retinopathy. The underlying cause behind most of these problems is the damage done to micro vessels due to prolonged exposure to high glucose and/ or advance glycation end products.



In patients with diabetic retinopathy, tissue abnormalities within the retina progress in two different phases: (1) in the early stage, endothelial cells in the micro-vessels lose their cell junctions, pericyte cells die and eventually basement membranes become more porous and blood vessels leak. This may cause obstruction of vision. (2) In the later stage, retinal ischemia and low oxygen tension (hypoxia), lead to pathological angiogenesis. Thus newly growing abnormal vessels cover the surface of the retina causing severe vision problems.

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My present research focuses on the role of different growth factors and cytokines like PAI-1, HGF, MMPs, in pathological angiogenesis and diabetic retinopathy. The underlying molecular mechanism and signal pathways are under investigation by in vitro culture of endothelial and pericyte cells and in vivo studies on mice and rat model.

Education, Honors and Professional Experience

  1. B.Sc (Zoology), University of Burdwan. WB. India (1992)
  2. M.Sc (Zoology), University of Burdwan. WB. India (1995)
  3. M.Phil, University of Burdwan. WB. India (1996)
  4. Ph.D. National Institute of Health and Family Welfare, New Delhi. India (2005)
Professional Experience
  1. Research assistant (1997-2006): National Institute of Health and Family Welfare, New Delhi. India.
  2. Post doctoral Fellowship. University of New Mexico, NM. USA (Since December 2006)

Recent Publications

Patents
  1. Basu A and Shrivastav TG. Simultaneous Immunoassay For Quantitative Estimation Of Progesterone And Human Chorionic Gonadotropin. [INDIAN PATENT] 1262/Del/200
  2. Basu A and Shrivastav TG. Reagent System For Simultaneous Enzyme Immunoassay. [INDIAN PATENT] 1261/Del/2006.
Book

Roy S and Basu A. Emergency Contraception and Use of Regular Contraceptives: A Guide for Medical Practitioners and Medical Officers. NIHFW Publication, New Delhi. (2002).

Research papers
  1. Basu A, Maitra SK and Shrivastav TG. Development of dual-enzyme-based simultaneous immunoassay for measurement of progesterone and human chorionic gonadotropin. Analytical Biochemistry 366; 175181: (2007).
  2. Basu A, Maitra SK and Shrivastav TG. A Direct Antigen Heterologous Enzyme Immunoassay for Progesterone in Serum without Using Displacer. Steroid 71 (3) 222-230; (2006).
  3. Basu A, Nara S, Chaube S. Rangari K, Kariya KP and Shrivastav TG. The influence of spacer-containing enzyme conjugate on the sensitivity and specificity of enzyme immunoassays for hapten. Clinica Chimica Acta. 366 (1-2), 287-292; (2006)
  4. Basu A, Maitra SK and Shrivastav TG. Development of isotopic and non-isotopic micro-well based immunoassays for hCG using 125I and biotin labeled hCG. Journal of Immunoassay and Immunochemistry 26 (4) 313-324; (2005).
  5. Basu A, Shrivastav TG and Kariya KP. Preparation of enzyme conjugate through adipic acid dihydrazide as linker and its use in immunoassay. Clin. Chem. 49(8), 1410-1412; (2003).
  6. Basu A and Shrivastav TG. One Step Enzyme Linked Immunosorbent Assay For Direct Estimation of Serum Cortisol. Journal of Immunoassy. 21(1), 39-50; (2000.)
  7. Shrivastav T.G., Basu A. and Kariya K.P. One step enzyme linked immunosobent assay for direct estimation of serum testosterone. Journal of Immunoassay and Immunochemistry. 24 (2), 205-217, (2003)
  8. Shrivastav T.G., Basu A. and Kariya.K.P Substitution of carbonate buffer by water for IgG immobilization in enzyme linked immunosobent assay. K.P. Journal of Immunoassay and Immunochemistry. 24 (2), 191-203, (2003.)
  9. Bhattacharya S, Dey R, Basu A, Maitra SK, Banerji TK. The structure of the pineal complex in a common Indian teleost, Catla catla: evidence for pineal-induced inhibition of testicular function within an annual reproductive cycle. Endocr. Res. 29(2): 141-56. (2003)
  10. Banerji TK, Maitra SK, Basu A and Hawkins HK. Lithium - Induced Alterations in the Testis of the Male Rose-ringed Parakeet (Psittacula krameri): Evidence for Significant Structural Changes and Disruption in the Spermatogenetic Activity. Endocr. Res. 25(1), 35-49 (1999).