Robert Orlando Lab

Principal Investigator

Robert A. Orlando, PhD

Associate Professor, Department of Biochemistry and Molecular Biology

Dr. Orlando received a PhD in 1989 from the Department of Developmental and Cell Biology at the University of California, Irvine. He completed postdoctoral fellowships at The Scripps Research Institute in 1991 and the University of California, San Diego in 1995. Dr. Orlando held a faculty position at the University of California, San Diego, before joining UNM in 2000.

Interests

  • Obesity-dependent inflammation
  • Lipid metabolism in obesity
  • Natural product drug discovery to identify anti-inflammatory agents

Recent Research

orlando labWork in the Orlando Lab has unveiled several identifications and characterizations, including:

  • A novel hepatic receptor that serves as the primary clearance receptor for atherogenic lipoproteins.
  • Associative properties of a tissue serine protease inhibitor with human breast cancer progression, suggesting a new tissue marker for breast cancer staging.
  • A curcumin-based analog that prevents peptide aggregation leading to Alzheimer’s disease pathologies and characterized and quantified the anti-inflammatory properties of numerous natural products.
  • A natural product with potent anti-inflammatory properties capable of preventing tissue pathologies of inflammatory bowel disease
  • A novel cellular cross-talk communication event in obese adipose tissue that may be responsible for chronic inflammation associated with obesity-dependent type II diabetes mellitus and atherogenic cardiovascular disease.