Laura V. Gonzalez Bosc, PhD

Biography

Dr. Gonzalez Bosc holds a PhD (2000) from the University of Buenos Aires, Argentina. She is the Director of the Biomedical Sciences Graduate Program (BSGP) at UNM, chairs the Institutional animal Care and Use Committee (IACUC), and directs the Cardiovascular and Metabolic Disease Signature Program (CMVD)

Areas of Specialty

  • Vascular biology
  • Pulmonary hypertension
  • Hypoxia
  • Inflammation

Achievements & Awards

  • Respiration Section New Investigator Award. 2010. American Physiological Society
  • Dalsemer Awar. Biomedical Research Grant. 2007. American Lung Association
  • Minority Travel Award to Experimental Biology. 2007. American Physiological Society/National Institute of Diabetes and Digestive and Kidney Diseases
  • Scientist Development Award. 2005. American Heart Association
  • Research Position. Programa Ramón y Cajal. 2004. Ministerio de Educación y Ciencia. Spain.
  • Affiliate Postdoctoral Fellowship. 2002 and 2004. American Heart Association

Key Publications

  • NFATc3 Regulation of Collagen V Expression Contributes to Cellular Immunity to Collagen Type V and Hypoxic Pulmonary Hypertension. Joshua R. Sheak, David T. Jones, Benjamin J Lantz, Levi D. Maston, Danielle Vigil, Thomas C. Resta, Micaela M. Resta, Tamara A. Howard, Nancy L. Kanagy, Yan Guo, Ewa Jankowska-Gan, Jeremy A. Sullivan, Rudolf K. Braun, William J. Burlingham, and Laura V. Gonzalez Bosc. Am J Physiol Lung Cell Mol Physiol. In-press. 2020
  • Ewa Jankowska-Gan, Vrushali V Agashe, Diego A Lema, Ying Zhou, Laura Gonzalez-Bosc, Jeremy Sullivan, Daniel S Greenspan, William J Burlingham. Donor HLA-DR drives the development of de novo autoimmunity following lung and heart transplantation. Transplantation Direct. In-press. 2020
  • Levi D. Maston, David T. Jones, Wieslawa Giermakowska, Tamara A. Howard, Judy L. Cannon, Wei Wang, Yongyi Wei, Weimin Xuan, Thomas C. Resta, Laura V. Gonzalez Bosc. Central Role of T Helper 17 Cells in Chronic Hypoxia-Induced Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2017. 312(5):L609-L624. PMC5451600
  • Maston LD, Jones DT, Giermakowska W, Resta TC, Ramiro-Diaz J, Howard TA, Jernigan NL, Herbert L, Maurice AA, Gonzalez Bosc LV. Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension. Pulm Circ. 2018 Jul-Sep;8(3):2045894018780734. PMC6055240
https://www.ncbi.nlm.nih.gov/myncbi/laura%20v.gonzalez%20bosc.1/bibliography/public/

Gender

Female

Languages

English, Spanish

Research

 pulmonary hypertension caused by chronic hypoxia

For the past 12 years, our research has focused on understanding the mechanisms that underlie the development of pulmonary hypertension caused by chronic hypoxia (CH).  We have made significant contributions to this field. My group was the first one to demonstrate that the calcium-regulated transcription factor, nuclear factor of activated T-cells isoform c3 (NFATc3) is required for CH-induced pulmonary arterial remodeling and hypertension. During the last 6 years, we have been studying the role of inflammation in CH-induced pulmonary hypertension. We have established that Th17 cells are localized in the perivascular region of pulmonary arteries after CH exposure and that these cells significantly contribute to the development of pulmonary hypertension. We recently identified that CH exposes collagen V in the perivascular region of pulmonary arteries, serving as a self-antigen that triggers a Th17-mediated inflammatory response contributing to pulmonary hypertension. Our research is funded by American Heart Association, NIH and Department of Defense.

Courses Taught

Medical Curriculum:

  • Phase I. Clinical Reasoning. University of New Mexico Health Science Center. Facilitator. Spring semester. 2016
  • Phase I. Gastrointestinal/Nutrition Block. University of New Mexico Health Science Center. Six students. Tutor (36 contact hours/year). 2015.
  • Phase I. Cardiovascular/Pulmonary/Renal Block. University of New Mexico Health Science Center. Six students. Tutor (36 contact hours/year). 2014.

Graduate School Curriculum:

  • Graduate Physiology (Biomed. Sci. 510). University of New Mexico Health Science Center. Lecturer (8 lecture hours/year). 2005 –
  • Advance Topics in Cellular and Systems Physiology (Biomed. Sci. 657). University of New Mexico Health Science Center. Lecturer (15 contact hours/year). 2005, 2007, 2011, 2013, 2017, 2020.

Research and Scholarship

Certification:

  • Instructor with pedagogic formation in university teaching. Orientation: health sciences. 1998. School of Pharmacy and Biochemistry. University of Buenos Aires.  Buenos Aires, Argentina