Piloting the Sexual and Gender Minority Cancer Curricular Advances for Research and Education (SGM Cancer CARE) Workshop: Research Training in the Service of SGM Cancer Health Equity

Kano M, Tamí-Maury I, Pratt-Chapman ML, Chang S, Kosich M, Quinn GP, Poteat T, Kanetsky PA, Elk R, Boehmer U, Sanchez J, Kamen C, Sanchez NF. | November 18, 2022

Health Literacy, Health Numeracy, and Cancer Screening Patterns in the Zuni Pueblo: Insights from and Limitations of "Standard" Questions

Cartwright K, Leekity S, Sheche J, Kanda D, Kosich M, Rodman J, Gonya M, Kelly K, Edwardson N, Pankratz VS, Mishra SI. | November 05, 2022

Genomic Variants Disrupt miRNA-mRNA Regulation

Xi E, Bai J, Zhang K, Yu H, Guo Y. | October 19, 2022

Logic-gated antibody pairs that selectively act on cells co-expressing two antigens

Oostindie SC, Rinaldi DA, Zom GG, Wester MJ, Paulet D, Al-Tamimi K, van der Meijden E, Scheick JR, Wilpshaar T, de Jong B, Hoff-van den Broek M, Grattan RM, Oosterhoff JJ, Vignau J, Verploegen S, Boross P, Beurskens FJ, Lidke DS, Schuurman J, de Jong RN. | October 10, 2022

Self-Selected Walking Cadence after 16-Week Light-Intensity Physical Activity Intervention for Older Cancer Survivors

Harding EM, Gibson AL, Kang H, Zuhl MN, Sharma H, Blair CK. | April 14, 2022

High-resolution mapping demonstrates inhibition of DNA excision repair by transcription factors

Duan M, Sivapragasam S, Antony JS, Ulibarri J, Hinz JM, Poon GMK, Wyrick JJ, Mao P. | March 15, 2022

Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation

Merkley SD, Goodfellow SM, Guo Y, Wilton ZER, Byrum JR, Schwalm KC, Dinwiddie DL, Gullapalli RR, Deretic V, Jimenez Hernandez A, Bradfute SB, In JG, Castillo EF. | February 23, 2022

Conditional transcriptional relationships may serve as cancer prognostic markers

Yu H, Wang L, Chen D, Li J, Guo Y. | December 02, 2021

EGFR transactivates RON to drive oncogenic crosstalk

Franco Nitta C, Green EW, Jhamba ED, Keth JM, Ortiz-Caraveo I, Grattan RM, Schodt DJ, Gibson AC, Rajput A, Lidke K, Wilson BS, Steinkamp MP, Lidke DS. | November 21, 2021

Detecting SARS-CoV-2 and its variant strains with a full genome tiling array

Jiang L, Guo Y, Yu H, Hoff K, Ding X, Zhou W, Edwards J. | November 05, 2021

RNA editing affects cis-regulatory elements and predicts adverse cancer survival

Yuan-Ming Wu, Yan Guo, Hui Yu, Tao Guo | September 10, 2021

Behavioral and Psychological Outcomes Associated with Skin Cancer Genetic Testing in Albuquerque Primary Care

Hay JL, Kaphingst KA, Buller D, Schofield E, Meyer White K, Sussman A, Guest D, Dailey YT, Robers E, Schwartz MR, Li Y, Hunley K, Berwick M. | August 12, 2021

Southwest Harvest for Health: An Adapted Mentored Vegetable Gardening Intervention for Cancer Survivors

Blair CK, Adsul P, Guest DD, Sussman AL, Cook LS, Harding EM, Rodman J, Duff D, Burgess E, Quezada K, Brown-Glaberman U, King TV, Baca E, Dayao Z, Pankratz VS, Davis S, Demark-Wahnefried W. | July 06, 2021

Dual-Mechanism Quenched Fluorogenic Probe Provides Selective and Rapid Detection of Cathepsin L Activity

Schleyer KA, Fetrow B, Zannes Fatland P, Liu J, Chaaban M, Ma B, Cui L. | April 08, 2021

Prognostic value and co-expression patterns of metabolic pathways in cancers

Dan Zhang , Yan Guo and Ni Xie | December 29, 2020
Background: Abnormal metabolic pathways have been considered as one of the hallmarks of cancer. While
numerous metabolic pathways have been studied in various cancers, the direct link between metabolic pathway
gene expression and cancer prognosis has not been established.
Results: Using two recently developed bioinformatics analysis methods, we evaluated the prognosis potential of
metabolic pathway expression and tumor-vs-normal dysregulations for up to 29 metabolic pathways in 33 cancer
types. Results show that increased metabolic gene expression within tumors corresponds to poor cancer prognosis.
Meta differential co-expression analysis identified four metabolic pathways with significant global co-expression
network disturbance between tumor and normal samples. Differential expression analysis of metabolic pathways
also demonstrated strong gene expression disturbance between paired tumor and normal samples.
Conclusion: Taken together, these results strongly suggested that metabolic pathway gene expressions are
disturbed after tumorigenesis. Within tumors, many metabolic pathways are upregulated for tumor cells to activate
corresponding metabolisms to sustain the required energy for cell division.
Keywords: Metabolic pathway, Meta co-expression analysis, Gene expression composite score, Cancer

Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis

Limin Jiang, Fei Guo, Jijun Tang , Shuguan Leng, Scott Ness, Fei Ye, Huining Kang, David C. Samuels and Yan Guo | December 04, 2020
Global autozygosity in the form of runs of homozygosity is associated with various diseases. Heterozygosity ratio, an alternative measure of global autozygosity, is used to assess cancer risk in this study. Our analysis shows strong and consistent associations between heterozygosity ratios and various cancer types. Further analysis reveals the heterozygosity ratio’s potential connections to mutational signatures and cancer prognosis.