Papers and Publications
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Papers and Publications
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation
Garcia SM, Naik JS, Resta TC, Jernigan NL. |
February 06, 2023
The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis
Kang H, Fichna J, Matlawska-Wasowska K, Jacenik D. |
December 01, 2022
Unbiased Identification of Dengue Virus Non-Structural Protein 1 Peptides for Use in Vaccine Design
Warner NL, Core SB, Frietze KM |
November 27, 2022
Piloting the Sexual and Gender Minority Cancer Curricular Advances for Research and Education (SGM Cancer CARE) Workshop: Research Training in the Service of SGM Cancer Health Equity
Kano M, TamÃ-Maury I, Pratt-Chapman ML, Chang S, Kosich M, Quinn GP, Poteat T, Kanetsky PA, Elk R, Boehmer U, Sanchez J, Kamen C, Sanchez NF. |
November 18, 2022
Health Literacy, Health Numeracy, and Cancer Screening Patterns in the Zuni Pueblo: Insights from and Limitations of "Standard" Questions
Cartwright K, Leekity S, Sheche J, Kanda D, Kosich M, Rodman J, Gonya M, Kelly K, Edwardson N, Pankratz VS, Mishra SI. |
November 05, 2022
Genomic Variants Disrupt miRNA-mRNA Regulation
Xi E, Bai J, Zhang K, Yu H, Guo Y. |
October 19, 2022
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens
Oostindie SC, Rinaldi DA, Zom GG, Wester MJ, Paulet D, Al-Tamimi K, van der Meijden E, Scheick JR, Wilpshaar T, de Jong B, Hoff-van den Broek M, Grattan RM, Oosterhoff JJ, Vignau J, Verploegen S, Boross P, Beurskens FJ, Lidke DS, Schuurman J, de Jong RN. |
October 10, 2022
Two-stage screened selection designs for randomized phase II trials with time-to-event endpoints
Wu J, Pan H, Hsu CW. |
October 07, 2022
Two-stage screened selection designs for randomized phase II trials with time-to-event endpoints
Wu J, Pan H, Hsu CW. |
June 05, 2022
Prediction of Major Histocompatibility Complex Binding with Bilateral and Variable Long Short Term Memory Networks
Jiang L, Tang J, Guo F, Guo Y. |
June 01, 2022
A Novel Strategy to Identify Prognosis-Relevant Gene Sets in Cancers
Pu J, Yu H, Guo Y. |
May 12, 2022
Self-Selected Walking Cadence after 16-Week Light-Intensity Physical Activity Intervention for Older Cancer Survivors
Harding EM, Gibson AL, Kang H, Zuhl MN, Sharma H, Blair CK. |
April 14, 2022
High-resolution mapping demonstrates inhibition of DNA excision repair by transcription factors
Duan M, Sivapragasam S, Antony JS, Ulibarri J, Hinz JM, Poon GMK, Wyrick JJ, Mao P. |
March 15, 2022
Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation
Merkley SD, Goodfellow SM, Guo Y, Wilton ZER, Byrum JR, Schwalm KC, Dinwiddie DL, Gullapalli RR, Deretic V, Jimenez Hernandez A, Bradfute SB, In JG, Castillo EF. |
February 23, 2022
Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair
Lake RJ, Bilkis R, Fan HY. |
February 02, 2022
Conditional transcriptional relationships may serve as cancer prognostic markers
Yu H, Wang L, Chen D, Li J, Guo Y. |
December 02, 2021
EGFR transactivates RON to drive oncogenic crosstalk
Franco Nitta C, Green EW, Jhamba ED, Keth JM, Ortiz-Caraveo I, Grattan RM, Schodt DJ, Gibson AC, Rajput A, Lidke K, Wilson BS, Steinkamp MP, Lidke DS. |
November 21, 2021
Detecting SARS-CoV-2 and its variant strains with a full genome tiling array
Jiang L, Guo Y, Yu H, Hoff K, Ding X, Zhou W, Edwards J. |
November 05, 2021
RNA editing affects cis-regulatory elements and predicts adverse cancer survival
Yuan-Ming Wu, Yan Guo, Hui Yu, Tao Guo |
September 10, 2021
Behavioral and Psychological Outcomes Associated with Skin Cancer Genetic Testing in Albuquerque Primary Care
Hay JL, Kaphingst KA, Buller D, Schofield E, Meyer White K, Sussman A, Guest D, Dailey YT, Robers E, Schwartz MR, Li Y, Hunley K, Berwick M. |
August 12, 2021
Southwest Harvest for Health: An Adapted Mentored Vegetable Gardening Intervention for Cancer Survivors
Blair CK, Adsul P, Guest DD, Sussman AL, Cook LS, Harding EM, Rodman J, Duff D, Burgess E, Quezada K, Brown-Glaberman U, King TV, Baca E, Dayao Z, Pankratz VS, Davis S, Demark-Wahnefried W. |
July 06, 2021
Development of Bacteriophage Virus-Like Particle Vaccines Displaying Conserved Epitopes of Dengue Virus Non-Structural Protein 1
Warner NL, Frietze KM. |
July 02, 2021
Rewired Pathways and Disrupted Pathway Crosstalk in Schizophrenia Transcriptomes by Multiple Differential Coexpression Methods
Yu H, Guo Y, Chen J, Chen X, Jia P, Zhao Z. |
April 29, 2021
Dual-Mechanism Quenched Fluorogenic Probe Provides Selective and Rapid Detection of Cathepsin L Activity
Schleyer KA, Fetrow B, Zannes Fatland P, Liu J, Chaaban M, Ma B, Cui L. |
April 08, 2021
Prognostic value and co-expression patterns of metabolic pathways in cancers
Dan Zhang , Yan Guo and Ni Xie |
December 29, 2020
Background: Abnormal metabolic pathways have been considered as one of the hallmarks of cancer. While
numerous metabolic pathways have been studied in various cancers, the direct link between metabolic pathway
gene expression and cancer prognosis has not been established.
Results: Using two recently developed bioinformatics analysis methods, we evaluated the prognosis potential of
metabolic pathway expression and tumor-vs-normal dysregulations for up to 29 metabolic pathways in 33 cancer
types. Results show that increased metabolic gene expression within tumors corresponds to poor cancer prognosis.
Meta differential co-expression analysis identified four metabolic pathways with significant global co-expression
network disturbance between tumor and normal samples. Differential expression analysis of metabolic pathways
also demonstrated strong gene expression disturbance between paired tumor and normal samples.
Conclusion: Taken together, these results strongly suggested that metabolic pathway gene expressions are
disturbed after tumorigenesis. Within tumors, many metabolic pathways are upregulated for tumor cells to activate
corresponding metabolisms to sustain the required energy for cell division.
Keywords: Metabolic pathway, Meta co-expression analysis, Gene expression composite score, Cancer
numerous metabolic pathways have been studied in various cancers, the direct link between metabolic pathway
gene expression and cancer prognosis has not been established.
Results: Using two recently developed bioinformatics analysis methods, we evaluated the prognosis potential of
metabolic pathway expression and tumor-vs-normal dysregulations for up to 29 metabolic pathways in 33 cancer
types. Results show that increased metabolic gene expression within tumors corresponds to poor cancer prognosis.
Meta differential co-expression analysis identified four metabolic pathways with significant global co-expression
network disturbance between tumor and normal samples. Differential expression analysis of metabolic pathways
also demonstrated strong gene expression disturbance between paired tumor and normal samples.
Conclusion: Taken together, these results strongly suggested that metabolic pathway gene expressions are
disturbed after tumorigenesis. Within tumors, many metabolic pathways are upregulated for tumor cells to activate
corresponding metabolisms to sustain the required energy for cell division.
Keywords: Metabolic pathway, Meta co-expression analysis, Gene expression composite score, Cancer
Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis
Limin Jiang, Fei Guo, Jijun Tang , Shuguan Leng, Scott Ness, Fei Ye, Huining Kang, David C. Samuels and Yan Guo |
December 04, 2020
Global autozygosity in the form of runs of homozygosity is associated with various diseases. Heterozygosity ratio, an alternative measure of global autozygosity, is used to assess cancer risk in this study. Our analysis shows strong and consistent associations between heterozygosity ratios and various cancer types. Further analysis reveals the heterozygosity ratio’s potential connections to mutational signatures and cancer prognosis.