Biography
Adcock received a BSc degree in Mathematics, Statistics and Operational Research (2014) from Cardiff University, and as MSc in Medical Statistics (2015) from the London School of Hygiene and Tropical Medicine (LSHTM). After 2 years working as a statistician at Queen Mary University of London (QMUL) she went on to complete a PhD in Cancer Prevention and biostatistics at QMUL in 2020.
Personal Statement
Statistical evaluations of population-based epidemiological studies supporting elucidation of the viral etiology of disease as well as prevention and diagnosis. My main focus is on the viral infection Human Papillomavirus (HPV). Prior and ongoing work in HPV has focused on triage strategies for HPV positive women, using combinations of cytology, viral genotyping, biomarker evaluation including immunohistochemical and immunocytochemical protein detection and host and viral gene methylation. Population-based cohorts in the United States (U.S.) and randomized trials in a routine screening setting in Italy have provided large databases for these statistical analyses. DNA methylation has been assessed as a predictor of cervical pre-cancer and cancer in self-collected samples in trials based in the United Kingdom (U.K.), and clinician collected samples in the U.S.
Further work has evaluated the uptake and impact of co-testing with HPV and cytology, which is a recommended screening strategy from the U.S. Preventive Services Task Force (USPSTF), in terms of disease endpoints.
Areas of Specialty
Medical Statistics
Cancer Prevention
Cervical Cancer and HPV
Key Publications
Journal Article
Adcock, Rachael, Cuzick, J, Hunt, W, C McDonald, R, M Wheeler, Cosette, 2019 Role of HPV Genotype, Multiple Infections, and Viral Load on the Risk of High-Grade Cervical Neoplasia. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 28, Issue 11, 1816-1824
Journal Article
Adcock, Rachael, Nedjai, B, Lorincz, A, T Scibior-Bentkowska, D, Banwait, R, Torrez-Martinez, N, Robertson, M, Cuzick, J, Wheeler, Cosette, 2022 DNA methylation testing with S5 for triage of high-risk HPV positive women. International journal of cancer, vol. 151, Issue 7, 993-1004
Journal Article
Cuzick, J, Adcock, Rachael, Carozzi, F, Gillio-Tos, A, De Marco, L, Del Mistro, A, Frayle, H, Girlando, S, Sani, C, Confortini, M, Zorzi, M, Giorgi-Rossi, P, Rizzolo, R, Ronco, G, 2020 Combined use of cytology, p16 immunostaining and genotyping for triage of women positive for high-risk human papillomavirus at primary screening. International journal of cancer, vol. 147, Issue 7, 1864-1873
Gender
Female
Languages
- English