Biography
B.S. Dalian Nationalities University, 2009
Ph.D. Nankai University, 2015
Postdoctoral Training, University of New Mexico, 2020
Research Assistant Professor, University of New Mexico, 2022
Email: jjia@salud.unm.edu
Personal Statement
My primary research goal is to seek a molecular understanding of how cells respond to lysosomal damage and maintain cellular metabolism and homeostasis. Building on my recent discovery that lysosomal damage induces stress granule formation, my team and I are dedicated to delving deeper into this area. Our objective is to uncover the mechanisms underlying the regulation and function of stress granule formation in response to lysosomal damage, and to understand its impact on cellular metabolism and homeostasis. Additionally, we aim to understand how membrane-bound organelles interact with membrane-less compartments during homeostasis and stress. This emerging research field holds numerous unanswered questions, and our aim is to contribute significantly to its advancement. Our research focus bears importance not only in understanding normal cellular functions but also in devising strategies to prevent the progression of diseases
PUBMED:https://www.ncbi.nlm.nih.gov/myncbi/1BGxxp_OTHgEO4/bibliography/public/
Areas of Specialty
Lysosomal Homeostasis; Cellular Stress Response; Cellular Signal Transduction; Stress granule; mTOR; AMPK; Autophagy
Education
B.S., M.D., Ph.D.
Achievements & Awards
2025 Invited presentation at the UNM Comprehensive Cancer Center’s Cellular and Molecular Oncology Research Program, Albuquerque, USA
2025 Invited presentation at the Diabetes and Metabolism Interest Group, University of Arizona and University of New Mexico, via Zoom.
2024 Invited presentation at Gordon Research Conference “Lysosomes and Endocytosis”, NH, USA
2024 Innovation Award for U.S. Patent No. 11819498, “Methods and Compositions for Treating Autophagy Related Disease States and Conditions Utilizing AMPK Activation,”
2024 Invited presentation at University of Arizona, Tucson, USA
2024 Invited presentation for Women in Autophagy online event
2023 Invited presentation at AIM Core Facility open house workshop, Albuquerque, USA
Gender
Female
Languages
- Mandarin
- English
Courses Taught
protein synthesis in the Advanced Molecular Biology (BIOM 507)
Research and Scholarship
Duran, J., Salinas, J. E., Wheaton, R. P., Poolsup, S., Allers, L., Rosas-Lemus, M., ... & Jia, J. 2024. Calcium signaling from damaged lysosomes induces cytoprotective stress granules. The EMBO Journal, 1-34.
Jia J., Wang F., Bhujabal Z., Peters R., Mudd M., Duque T., Allers L., Javed R., Salemi M., Behrends C., Phinney B., Johansen T., Deretic V. Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage. J Cell Biol. 2022 Nov 7; 221(11): e202207091.
Jia, J., Bissa, B., Brecht, L., Allers, L., Choi, S., Gu, Y., Zbinden, M., Burge, M.,Timmins, G., Hallows, K.,Behrends, C., Deretic, V. (2020). AMPK, a key regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin-directed ubiquitin signal transduction system. Molecular Cell 77, 1-19.
Jia, J., Claude-Taupin, A., Gu, Y., Choi, S., Peters, R., Bissa, B., Mudd, M., Allers, L., Pallikkuth, S., Lidke, K., Salemi, M., Phinney, B., Mari, M., Reggiori, F., Deretic, V. (2020). Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal. Developmental Cell, 52(1), 69-87.
Jia, J., Abudu, Y.P., Claude-Taupin, A., Gu, Y., Kumar, S., Choi, S.W., Peters, R., Mudd, M.H., Allers, L., Salemi, M., et al. (2018). Galectins Control mTOR in Response to Endomembrane Damage. Molecular Cell 70, 120-135.e8.