Vojo Deretic, PhD

Key Publications

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation. Kumar S, Gu Y, Abudu YP, Bruun JA, Jain A, Farzam F, Mudd M, Anonsen JH, Rusten TE, Kasof G, Ktistakis N, Lidke KA, Johansen T, Deretic V. Dev Cell. 2019 Feb 27. pii: S1534-5807(19)30055-3.

Galectins Control mTOR in Response to Endomembrane Damage. Jia J, Abudu YP, Claude-Taupin A, Gu Y, Kumar S, Choi SW, Peters R, Mudd MH, Allers L, Salemi M, Phinney B, Johansen T, Deretic V. Mol Cell. 2018 Apr 5;70(1):120-135.e8.

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd MH, Kimura T, Choi SW, Peters R, Mandell M, Bruun JA, Johansen T, Deretic V. Dev Cell. 2016 Sep 28 doi: 10.1016/j.devcel.2016.08.003.

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Chauhan S, Ahmed Z, Bradfute SB, Arko-Mensah J, Mandell MA, Won Choi S, Kimura T, Blanchet F, Waller A, Mudd MH, Jiang S, Sklar L, Timmins GS, Maphis N, Bhaskar K, Piguet V, Deretic V. Nat Commun. 2015 Oct 27;6:8620. doi: 10.1038/ncomms9620.

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V. J Cell Biol. 2015 Sep 14;210(6):973-89.

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases. Rubinsztein DC, Bento CF, Deretic V. J Exp Med. 2015 Jun 29;212(7):979-90.

IRGM governs the core autophagy machinery to conduct antimicrobial defense. Chauhan S, Mandell MA, Deretic V. Mol Cell. 2015 May 7;58(3):507-21.

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognitionMandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Münch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V. Dev Cell. 2014 Aug 25;30(4):394-409.

Autophagy in infection, inflammation and immunityDeretic V, Saitoh T, Akira S. Nat Rev Immunol. 2013 Oct;13(10):722-37.

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM, Deretic V. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76.

TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturationPilli M, Arko-Mensah J, Ponpuak M, Roberts E, Master S, Mandell MA, Dupont N, Ornatowski W, Jiang S, Bradfute SB, Bruun JA, Hansen TE, Johansen T, Deretic V. Immunity. 2012 Aug 24;37(2):223-34.

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1βDupont N, Jiang S, Pilli M, Ornatowski W, Bhattacharya D, Deretic V. EMBO J. 2011 Nov 8;30(23):4701-11.

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondriaSingh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, Ponpuak M, Master S, Pilli M, White E, Komatsu M, Deretic V. Nat Cell Biol. 2010 Dec;12(12):1154-65.

Human IRGM induces autophagy to eliminate intracellular mycobacteriaSingh SB, Davis AS, Taylor GA, Deretic V. Science. 2006 Sep 8;313(5792):1438-41.

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesGutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Cell. 2004 Dec 17;119(6):753-66.

Research and Scholarship

Dr. Deretic is Director of the NIH-funded Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence. AIM is a nationally, internationally, and locally important center for advancement of research on autophagy in disease. It is an intellectual and technological hub for autophagy and its intersections with inflammation and metabolism in a full spectrum of diseases.

It endows the state of New Mexico and the region with a cutting edge biomedical center of excellence while giving the nation a resource for both basic science and for development of new approaches in treating a wide spectrum of disease. AIM supports both junior and senior investigators through multi-year projects and pilots and aims to grow into an internationally known center by its scientific output and impact

AIM will host national and international activities, promote collaborations, and will provide career opportunities at many levels. The AIM center is funded by NIH grant P20GM121176.

Dr. Deretic's main contributions to science come from studies by his team on the role of autophagy in infection and immunity. Autophagy, a cytoplasmic pathway for the removal of damaged or surplus organelles, has been previously implicated in cancer, neurodegeneration, development, and aging.

Dr. Deretic's group is one of those that made the discovery that autophagic degradation is a major effector and aregulator of innate and adaptive immunity mechanisms for direct elimination of intracellular microbes. His current work is on the role of autophagy in immunity and inflammation, interactions with lipid metabolism, and fundamental mechanisms of how selective autophagy is regulated in mammalian cells.