Biography
Dr. Endicott completed his B.A. in Molecular Biology and Chemistry in 2011. He earned his Ph.D. in Genetics from Yale University in 2016. Following the completion of his Ph.D., Dr. Endicott completed a postdoctoral fellowship at the University of Michigan in 2021. Dr. Endicott worked as a Research Investigator at the University of Michigan until 2024, when he joined UNM as an Assistant Professor.
Personal Statement
My multi-disciplinary research uses a combination of quantitative proteomics, biochemistry, microscopy, cell biology, and mouse studies to address questions pertaining to chaperone-mediated autophagy (CMA). CMA is a selective form of lysosomal proteolysis, which targets individual proteins for lysosomal degradation, independent of vesicle fusion. Through selective proteolysis of rate-limiting enzymes, CMA regulates essential metabolic processes, such as glycolysis, cytoplasmic acetyl-coA production, fatty acid synthesis, and translation at the cytoplasmic ribosome.
My research program addresses two broad questions:
1. How is CMA regulated at the endocrine, cellular, and sub-cellular levels?
2. What are the targets of CMA, and how does their degradation affect metabolism, health, and longevity?
Areas of Specialty
Chaperone-mediated autophagy
Cell Biology
Biochemistry
Intracellular signaling
Aging
Key Publications
Journal Article
Endicott, Samuel, Boynton, Jr, Dennis, N Beckmann, Logan, J Miller, Richard, A 2021 Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy Autophagy, vol. 17, Issue 3, 612--625
Journal Article
Endicott, Samuel, Ziemba, Zachary, J Beckmann, Logan, J Boynton, Jr, Dennis, N Miller, Richard, A 2020 Inhibition of class I PI3K enhances chaperone-mediated autophagy Journal of Cell Biology, vol. 219, Issue 12, e202001031
Journal Article
Endicott, Samuel, Monovich, Alexander, C Huang, Eric, L Henry, Evelynn, I Boynton, Dennis, N Beckmann, Logan, J MacCoss, Michael, J Miller, Richard, A 2022 Lysosomal targetomics of ghr KO mice shows chaperone-mediated autophagy degrades nucleocytosolic acetyl-coA enzymes Autophagy, vol. 18, Issue 7, 1551--1571
Journal Article
Zhang, Katherine, K Burns, Calvin, M Skinner, Mary, E Lombard, David, B Miller, Richard, A Endicott, Samuel, 2023 PTEN is both an activator and a substrate of chaperone-mediated autophagy Journal of Cell Biology, vol. 222, Issue 9, e202208150
Journal Article
Burns, Calvin, M Miller, Richard, A Endicott, Samuel, 2024 Histodenz Separation of Lysosomal Subpopulations for Analysis of Chaperone-mediated Autophagy Current Protocols, vol. 4, Issue 1, e950
Gender
Male
Languages
- English