Biography
Dr. Gonzalez Bosc holds a PhD (2001) from the University of Buenos Aires (Argentina). She is the director of the Biomedical Sciences Graduate Program (BSGP) at UNM, directs the Cardiovascular and Metabolic Disease Signature Program (CMVD), and is the former chair of the Institutional Animal Care and Use Committee (IACUC).
Personal Statement
I value and embrace diversity in the workplace. I have always felt welcomed, respected, and supported by members of my Department. I’m committed to contributing to a work environment that promotes anti-racism and social justice.
Areas of Specialty
Vascular Biology, Pulmonary Hypertension, Hypoxia, Inflammation
Achievements & Awards
Respiration Section New Investigator Award. American Physiological Society. 2010.
Dalsemer Award. Biomedical Research Grant. 2007. American Lung Association.
Minority Travel Award to Experimental Biology. American Physiological Society/National Institute of Diabetes and Digestive and Kidney Diseases. 2007.
Scientist Development Award. American Heart Association. 2005.
Key Publications
Journal Article
Morales-Loredo, H, Jones, D, Barrera, A, Mendiola, P, J Garcia, J, Pace, C, Murphy, M, Kanagy, Nancy, Gonzalez Bosc, Laura, 2019 A dual blocker of endothelin A/B receptors mitigates hypertension but not renal dysfunction in a rat model of chronic kidney disease and sleep apnea. American journal of physiology. Renal physiology, vol. 316, Issue 5, F1041-F1052
Journal Article
Gonzalez Bosc, Laura, V Mendiola, Perenkita, Gardiner, Amy , Birg, Alexsandr, Naik, Jay, Kanagy, Nancy, Hydrogen sulfide and the vasculature Comprehensive Physiology
Journal Article
Maston, L, D Jones, D, T Giermakowska, W, Howard, T, A Cannon, Judy, Wang, W, Wei, Y, Xuan, W, Resta, Tom, Gonzalez Bosc, Laura, 2017 Central role of T helper 17 cells in chronic hypoxia-induced pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology, vol. 312, Issue 5, L609-L624
Journal Article
Gonzalez Bosc, Laura, Plomaritas, D, R Herbert, L, M Giermakowska, W, Browning, C, Jernigan, Nikki, 2016 ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology, vol. 311, Issue 1, L48-58
Gender
Female
Languages
- Spanish
- English
Research
For the past 12 years, our research has focused on understanding the mechanisms that underlie the development of pulmonary hypertension caused by chronic hypoxia (CH). We have made significant contributions to this field. My group was the first one to demonstrate that the calcium-regulated transcription factor, nuclear factor of activated T-cells isoform c3 (NFATc3) is required for CH-induced pulmonary arterial remodeling and hypertension. During the last 6 years, we have been studying the role of inflammation in CH-induced pulmonary hypertension. We have established that Th17 cells are localized in the perivascular region of pulmonary arteries after CH exposure and that these cells significantly contribute to the development of pulmonary hypertension. We recently identified that CH exposes collagen V in the perivascular region of pulmonary arteries, serving as a self-antigen that triggers a Th17-mediated inflammatory response contributing to pulmonary hypertension. Our research is funded by American Heart Association, NIH and Department of Defense.
Courses Taught
Medical School
Phase I. Pharmacology COPD and Asthma. Peer Instruction. Cardiovascular/Pulmonary/Renal Block. Spring 2020-2021
Phase I. Clinical Reasoning. Group Facilitator. Spring semester. 2016 - 2019
Phase I. Gastrointestinal/Nutrition Block. Tutor. 2015.
Phase I. Cardiovascular/Pulmonary/Renal Block. Tutor. 2014.
Phase I. Cardiovascular/Pulmonary/Renal Block. Tutor. 2014.
Cardiovascular/Pulmonary/Renal Block co-Chair 2017-2020
Graduate School
Course Director, Graduate Physiology (Biomed. Sci. 510). University of New Mexico Health Science Center. Spring 2010, 2015 and 2016.
Graduate Physiology (Biomed. Sci. 510). University of New Mexico Health Science Center. Lecturer (8 lecture hours/year). 2005 - Present.
Advance Topics in Cellular and Systems Physiology (Biomed. Sci. 657). University of New Mexico Health Science Center. Lecturer (15 contact hours/year). 2005, 2007, 2011, 2013.