Biography
Dr. Hathaway received a B.S. Ag. in Plant Science from the University of Delaware in 1979. She went on to graduate school at Rutgers University where she received her Ph.D. degree in Biology in 1986. She then completed a postdoctoral fellowship in cell and developmental biology at M.D. Anderson Cancer Center, followed by a position as Research Associate. After a brief move to Emory University as a Research Assistant Professor, Dr. Hathaway took a tenure-track faculty position in the Department of Cell Biology and Physiology at the University of New Mexico School of Medicine.
Personal Statement
The overall goal of my research has been to dissect the mechanisms by which cells respond to environmental cues, and how those interactions are altered during the progression from normal to neoplastic disease in women?s cancers. My training in cell and developmental biology provided the foundation for investigations into mechanisms by which normal cellular interactions are coopted during malignant progression. My earlier research examined the role of cell surface b1,4-galactosyltransferase in development of the mammary gland, focusing on functions in cell migration and cell survival. My current research focuses on breast tumor biology, mechanisms of hormone therapy resistance, the breast tumor microenvironment and molecular mechanisms of metastasis, and detection/therapeutic strategies for breast cancer. Recent projects include; dissecting the role of the novel G protein-coupled estrogen receptor, GPER, in women?s cancers and metabolic disorders; breast cancer detection using magnetic nanoparticles and a novel superconducting quantum interference device; elucidating the role of the tissue microenvironment adjacent to breast tumors in modulating transformation toward a tumor-like phenotype; effects of the secreted myokine irisin as a tumor suppressor. My research has been funded by the NIH, the Department of Defense Breast Cancer Research Program, and the American Cancer Society.
I have served as a mentor for 4 postdoctoral fellows, 6 graduate students, 2 medical students, and 27 undergraduate students, including 34 women and 17 students from underrepresented groups. I also served as the subaward PI for an NIH Building Infrastructure Leading to Diversity (BUILD) Initiative, BUILDing SCHOLARS, led by a team at the University of Texas, El Paso. Based on my mentoring experience I was selected to serve as Director of the Biomedical Sciences Graduate Program (2008 - 2013), where I led efforts to educate graduate students in the development of career skills, including oral and written presentations, grant writing, and the responsible conduct of research.
Areas of Specialty
Breast Cancer
Estrogen-dependent signaling
Tumor microenvironment
Cell-Matrix Interactions
Magnetic nanoparticle-based cancer detection
Achievements & Awards
Director, Biomedical Sciences Graduate Program, 2008-2013
Medical Education Scholars Program, 2013-2015
Nomination for Team Science Research Award, UNM HSC, 2016
Exemplary Teacher Recognition UNM SOM Learning Environment Office (student nominated), 2021
Key Publications
Journal Article
Oshima, N, Ishida, R, Kishimoto, S, Beebe, K, Brender, J, R Yamamoto, K, Urban, D, Rai, G, Johnson, M, S Benavides, G, Squadrito, G, L Crooks, D, Jackson, J, Joshi, A, Mott, B, T 2020 Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy. Cell reports, vol. 30, Issue 6, 1798-1810.e4
Journal Article
Rai, G, Urban, D, J Mott, B, T Hu, X, Yang, S, M Benavides, G, A Johnson, M, S Squadrito, G, L Brimacombe, K, R Lee, T, D Cheff, D, M Zhu, H, Henderson, M, J Pohida, K, Sulikowski, G, A 2020 Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. Journal of medicinal chemistry, vol. 63, Issue 19, 10984-11011
Gender
Female
Languages
- English
Courses Taught
1. Co-Block Chair, Cardiovascular, Pulmonary, and Renal Systems, School of Medicine Phase I, 2018 - 2022
2. Co-Block Chair, Molecular Foundations of Medicine, School of Medicine Phase I, 2021 - 2022
3. Course Director, Advanced Cell Biology, Biomedical Sciences Graduate Program, 2007 - 2016
Research and Scholarship
1. Sharma, G., Hu, C., Staquicini, D.L., Brigman, J.L., Liu, M., Mauvais-Jarvis, F., Pasqualini, R., Arap, W., Arterburn, J.B., Hathaway, H.J., and Prossnitz, E.R. (2020) Preclinical efficacy of a first-in-class selective GPER agonist in male and female mouse models of obesity and diabetes. Sci. Trans. Med., 2020;12(528). PMCID: PMC7083206
2. Revankar, C. M., Bologa, C. G., Pepermans, R. A., Sharma, G., Petrie, W. K., Alcon, S. N., Field, A. S., Ramesh, C., Parker, M. A., Savchuk, N. P., Larry A. Sklar, L. A., Hathaway, H. J., Arterburn, J. B., Oprea, T. I., and Prossnitz, E. R. (2019) A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling. Cell Chem. Biol. 26(12):1692-702 e5, doi: 10.1016/j.chembiol.2019.10.009. PMCID: PMC6925632
3. Scaling, A. L., Prossnitz, E. R.*, and Hathaway, H. J.* (2014) GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells, and normal and malignant breast. Hormones and Cancer, 5:146-160. PMCID: PMC4091989. *equal contribution.
4. Marjon, N. A., Hu, C., Hathaway, H. J.,* and Prossnitz, E. R.* (2014) G protein-coupled estrogen receptor GPER regulates mammary tumorigenesis. Mol. Cancer Res., 12:1644-1654. *equal contribution. PMCID: PMC4233188.
5. Hathaway, H. J*., Butler, K. S*., Adolphi, N. L.,Lovato, D. M., Belfon, R., Fegan, D., Monson, T. C., Trujillo, J. E., Tessier, T. E., Bryant, H. C., Huber, D. L., Larson, R. S., and, Flynn, E. R. (2011) Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors. Breast Cancer Res., 13:R108. PMCID: PMC3262221. (*Equal contribution)