Biography
Lidke received her B.S. degree in Physics in 1994. She earned her PhD in Biophysical Sciences & Medical Physics from the University of Minnesota in 2002. Her postdoctoral research was in the lab of Thomas Jovin at the Max Planck Institute for Biophysical Chemistry in Goettingen, Germany. She joined the UNM Pathology Department in 2005.
Personal Statement
Lidke’s research integrates the disciplines of biophysics, bio-imaging and quantitative biology to gain new and fundamental understanding of the components and dynamics of cell signaling pathways. This involves the measurement of protein behavior in living cells to capture and quantify biochemical events that initiate signaling. Her focus is on the study of the of receptor tyrosine kinases and immunoreceptors, and how these are altered in disease or influenced by therapeutics.
Areas of Specialty
Fluorescence Microscopy
Cell Signaling
Biophysics
Receptor Tyrosine Kinases
ITAM signaling
Achievements & Awards
UNM “Apple for the teacher” Educational Excellence Award, 2016
UNM BSGP Outstanding Mentor Award, 2016
Margaret Oakley Dayhoff Award from the Biophysical Society, 2011
UNM-HSC Jr. Faculty Excellence in Research Award, 2010
Languages
- English
Research and Scholarship
N.L. Andrews, J.R. Pfeiffer, A.M. Martinez, D.M. Haaland, R.W. Davis, T. Kawakami, J.M. Oliver, B.S. Wilson and D.S. Lidke. “Small, mobile Fc?RI aggregates are signaling competent.” Immunity, 31: 469-479 (2009) PMC2828771
S.T. Low-Nam, K.A. Lidke, P.J. Cutler, R.C. Roovers, P.M.P. van Bergen en Henegouwen, B.S. Wilson, D.S. Lidke. “ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand.” Nature Structural & Molecular Biology, 18: 1244-1249 (2011) PMC3210321
S.L. Schwartz, C. Cleyrat, M. Olah, P. Relich, G. Phillips, W.S. Hlavacek, K.A. Lidke, B.S. Wilson and D.S. Lidke. “Differential mast cell outcomes are sensitive to Fc?RI-Syk binding kinetics.” Molecular Biology of the Cell - Quantitative Biology Special Issue 28: 3397-3414 (2017) PMC5687039**MBoC Highlight article
A.M. Brandsma*, S.L. Schwartz*, C.C. Valley, G.L.A. Blezer, G. Vidarsson, K.A. Lidke, T. ten Broeke, D.S. Lidke^, J.H.W. Leusen^. “Mechanisms of inside-out signaling of the high affinity IgG-receptor Fc?RI.” Science Signaling. 11: eaaq0891 (2018) PMID: 30042128 ^Lidke and Leusen are co-corresponding authors.
E. Salazar-Cavazos, C. Franco Nitta, E.D. Mitra, B.S. Wilson, K.A. Lidke, W.S. Hlavacek, Lidke, D.S. “Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes.” Molecular Biology of the Cell, 19:695-708 (2020) PMC7202077