Biography
Dr. Osley received a B.A. in Biology from Wheaton College, Norton, MA (1967).
She earned her PhD degree in Microbiology (1974) from Yale University.
Following her PhD degree she completed postdoctoral research at Princeton University and Harvard Medical School. Before joining the Molecular Genetics and Microbiology Department at the UNM Health Sciences Center, she had a faculty position in the Molecular Biology Program at Sloan Kettering Cancer Center.
Personal Statement
I started my career using yeast as a model organism and have continued to focus my research in yeast because of its outstanding genetic systems. For the past 25 years I have been interested in the role of chromatin in gene regulation, DNA replication, and DNA repair. While the scope of my research is broad, it has allowed me to investigate multiple areas of genome regulation. My current research is focused on understanding how cells exit the mitotic cell cycle and enter a state of quiescence, and conversely, how cells the re-enter the cell cycle from the quiescent state. I am a member of the UNM Cancer Center, and this research is very relevant to the control of cancer stem cells.
Areas of Specialty
Chromatin
Gene Regulation
DNA Replication/Cell Cycle
DNA Repair
Cellular Quiescence
Certifications
N/A
Achievements & Awards
NIH postdoctoral fellowship, 1974-1977
The Victor and Ruby Hansen Surface Endowed Professor, 2013-present
Distinguished Professor, 2021-present
Gender
Female
Languages
- English
Courses Taught
????Advanced Molecular Biology for first year BSGP graduate students
Methods in Molecular Biology for first year BSGP graduate students
Research and Scholarship
Robzyk K, Recht J and Osley MA: Rad6-dependent ubiquitination of histone H2B in yeast. Science, 287: 501-504, 2000.
Tsukuda, T, Fleming, A, Nickoloff, J.A, and Osley, MA: Chromatin remodeling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature 438: 379-383, 2005.
Fleming, AB, Kao, C-F, Hillyer, C, Pikaart, M, and Osley, MA: H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. Mol Cell, 31: 57-66, 2008.
Trujillo, KM and Osley, MA: A role for H2B ubiquitylation in DNA replication. Mol Cell, 48: 734-746, 2012.
Young, CP, Hillyer, C, Hokamp, K, Fitzpatrick, D, Konstantinov, NK, Welty, JS, Ness, SA, Werner-Washburne, M, Fleming, A, and Osley, MA. Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast. BMC Genomics epub Jan 26, 2017.