Biography
Dr. Paramasivam is an Adjunct Research Assistant Professor in Pharmaceutical Sciences at the College of Pharmacy, University of New Mexico. He earned his Ph.D. in Biochemistry and Molecular Biology from the University of Madras in 2020. His research focuses on environmental microplastics, pain signaling, neurodegenerative diseases and metabolic diseases.
Personal Statement
My research focuses on how environmental microplastics interact with human brain microvascular endothelial cells at the blood–brain barrier. My research investigates explicitly how different apolipoprotein genotypes, particularly ApoE4, modify the uptake, transport, and toxicity of microplastic nanoparticles (MNPs) at the neurovascular interface. The work tests the idea that circulating apolipoproteins can chaperone MNPs in blood, altering their corona composition and ability to cross brain barriers. By establishing a gene–environment (GxE) framework, this research links ApoE4?dependent handling of microplastics to endothelial injury and impaired barrier integrity. Ultimately, it addresses how these mechanisms may increase risk for dementia and related neurodegenerative diseases, including Alzheimer’s disease.
Areas of Specialty
Microplastics
Neurodegenerative Diseases
Education
2000 BS Microbiology, Bharathidasan University, INDIA
2006 MS BioMedical Instrumentation Sciences, University of Madras, INDIA
2020 PhD Biochemistry and Molecular Biology, University of Madras, INDIA
Key Publications
Journal Article
Paramasivam, Prabu, Meugnier, Emmanuelle, Gokulakrishnan, Kuppan, Ranjani, Harish, Staimez, Lisa, R. Weber, Mary, Beth Narayan, K., M. Vidal, Hubert, Tandon, Nikhil, Prabhakaran, Dorairaj, Anjana, Ranjit, Mohan Mohan, Viswanathan, Rome, Sophie, Balasubramanyam, Muthuswamy, 2022 Correction: Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation PLOS ONE, vol. 17, Issue 7, e0272323 https://doi.org/10.1371/journal.pone.0272323
Languages
- English
- Tamil
Research and Scholarship
https://www.ncbi.nlm.nih.gov/myncbi/1PIZddBpfPTk7/bibliography/public/