Biography
Currently, I am a Research Assistant professor in Department of Pharmaceutical Sciences, UNM COP.
I graduated from Hiroshima University in Japan at 2000 with a PhD degree in Biosphere Sciences. While in the graduate school, I earned several scholarships for supporting my PhD performance. My PhD work was to address the effect of dietary fat on the activity of inducible nitric oxide synthase (iNos) and the association of high fat food induced activation of iNos with the formation of colon aberrant crypt foci (ACF). ACF is one of the earliest changes seen in the colon that may lead to cancer.
I took my first research position from 2000 to 2005 as a research scientist in National Research Institute of Brewing, Hiroshima, Japan. Where, I conducted the study of signal transduction in anthocyanin biosynthesis pathway of grape. On August of 2005, as a Postdoctoral fellow, I joined a laboratory in Department of Molecular biology and Biochemistry, UNM SOM and worked on the study related to Cure of Human Genetic Disease and Cancer in the field of programmed cell death. I was promoted to a research scientist two years later. Then at 2009, I was promoted to a research assistant professor in department of surgery, UNM SOM and started working on the research projects on the molecular mechanisms of PI3K mutation induced colorectal cancer metastasis. Since the end of 2018, I joined to Dr. Liu?s laboratory in UNM COP. My research activity focused on the study of the molecular mechanism underlying environmental arsenic exposure induced anemia.
Personal Statement
I have strong background in molecular biology, cell biology, and cancer biology. In the early days of my research career, the research projects were scattered in different areas including food nutrition and health, plant science, and cancer research due to the job opportunities. I have had the expertise, training, research experience and skills, and also the motivation necessary to successfully carry out the research related to molecular biology and cell biology in human health and medical sciences.
During the 11 years that I have been a research faculty member at the University of New Mexico, I have been given the opportunity to conduct the research in the different areas including apoptosis and autophagic cell death in cancer, molecular processes that result in metastases in colorectal cancer, and environmental arsenic exposure induced inhibition of erythropoiesis.
Since the end of 2018, as a research assistant professor, I am playing the major role in the research project entitled 'Arsenic, GATA1 and Anemia' which is the R01-funded project. Arsenic exposure poses a constant threat to people?s health, it could cause anemia by inhibiting the formation of red blood cells (RBCs). However, how arsenic exposure inhibits RBCs formation are largely unclear. The goal of my study is to understand the molecular mechanism by which environmental arsenic exposure induces anemia. In the past two years, I have successfully applied the Human in vitro CD34+ cell model into our project and have obtained important meaningful data, which already or could contribute to research articles and funding application.
Areas of Specialty
Apoptosis,
autophagy,
colorectal cancer metastasis,
PI3K mutation and signaling pathway,
erythropoiesis
Education
PhD
Achievements & Awards
Publications:
1. X. Zhou, S. Medina, A. M. Bolt, H. Zhang, G. Wan, H. Xu, F. T. Lauer, S. C. Wang, S. W. Burchiel and K. J. Liu (2020). 'Inhibition of red blood cell development by arsenic-induced disruption of GATA-1.' Sci Rep 10(1): 19055. https://www.ncbi.nlm.nih.gov/pubmed/33149232
2. I. Murphy, G.Wan, S. Fu, Y. Liu, Y. Qiu, T. Ma, W. Laskey, H. Chand, L. Sklar, & C.-A. Andy Hu (2020) ApoL6 Induces Dichotomous Cell Death Phenotype Involving Both Apoptosis and Necroptosis in Cancer Cells. Clinical Oncology & Research, 3: 6-9, http://dx.doi.org/10.31487/j.COR.2020.07.12
In submission
1. Guanghua Wan, Sebastian Medina, Haikun Zhang, Rong Pan, Xixi Zhou, Alicia M Bolt, Scott W. Burchiel and Ke Jian Liu*Arsenite Exposure Increases CD71 expression and Decreases Hemoglobin Production during Erythroid Development of Human Hematopoietic Progenitor CD34+ Cells (in submission toSci Rep)
2. Sebastian Medina, Alicia M. Bolt, Xixi Zhou, Guanghua Wan, Huan Xu, Fredine T. Lauer, Ke Jian Liu, and Scott W. Burchiel* Arsenite and Monomethylarsonous Acid Disrupt Erythropoiesis Through Combined Effects on Differentiation and Survival Pathways in Early Erythroid Progenitors (in resubmission)
Award:
COP pilot project
01/01/2020-12/30/2020
Arsenic exposure affects erythropoiesis via promoting an abnormal mitophagy
Key Publications
Journal Article
Wan, Guanghua, G Bcl-2 together with PI3K p110? regulates cell morphology and cell migration Cell death & disease, vol. 6, Issue 12, e2006-e2006
Journal Article
Wan, Guanghua, G The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells Cell Death Discov, vol. 1
Journal Article
Greenbaum, Alissa, Rajput, Ashwani, Wan, Guanghua, 2016 RON kinase isoforms demonstrate variable cell motility in normal cells HELIYON, vol. 2, Issue 9
Journal Article
Zhaorigetu, Siqin, Wan, Guanghua, Kaini, Ramesh, Jiang, Zeyu, Hu, Chien-an, A. 2008 ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death AUTOPHAGY, vol. 4, Issue 8, 1079-1082
Journal Article
Wan, Guanghua, Zhaorigetu, Siqin, Liu, Zhihe, Kaini, Ramesh, Jiang, Zeyu, Hu, Chien-an, A. 2008 Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, Issue 31, 21540-21549
Languages
- Chinese
- Japanese
- English