Pre-Clinical Core and Clinical Neuropsychology Core

Pre-Clinical Core: Behavioral, Optical, Histological, & Electrophysiological Assessment

MISSION

The Pre-Clinical Core is a component of the Center from Brain Recovery and Repair (P20GM109089). Its mission is to establish a centralized resource and expertise on automated behavior, in-vivo detection of neuronal activity, and structural analyses applicable to a range of pre-clinical models of brain and behavioral illnesses.

The Pre-Clinical Core is designed for researchers to quickly and efficiently test their pre-clinical disease model at the behavioral, neuronal activity, and histological level in one place.

Key Personnel

Lee Anna Cunningham, PhD
Pre-Clinical Core Director

Jonathan Brigman, PhD
Associate Core Director

Russell Morton, PhD
Core Manager

Frequently Asked Questions

Q. What behavioral task do you offer?
A. 
The Pre-Clinical Core offers motion tracking system (e.g. open field, novel object recognition etc.), advanced gait analysis, rotarod, and automated fear conditioning and touch-screen behavioral tasks. Most behavior can be integrated with in-vivo electrophysiology.

Q: What species does the Pre-Clinical Core work with?
A: 
The Pre-Clinical Core is a facility focused on mouse models of neurological disease.

Q: What microscopy techniques does the Pre-Clinical Core offer?
A: 
We offer in-vivo anesthetized and ex-vivo multi-photon imaging, in-vivo single photon imaging, laser speckle contrast imaging, and in-vivo awake/behaving mini-scope fluorescence imaging.

Q:  What type of histology services does the Pre-Clinical Core offer?
A: 
We offer tissue processing and mounting, tissue sectioning (sliding knife, vibrating vibratome, and cryostat), basic immunohistochemistry, tissue clearing, and Imaris 3D and 4D image analysis.

Clinical Neuropsychology Core

MISSIONClinical Neuropsychology Core

The Clinical Neuropsychology Core is a component of the Center for Brain Recovery and Repair (P20GM109089). Its mission is to provide a centralized, interdisciplinary clinical research facility that provides state-of-the-art neuropsychological, neural stimulation, and neuroimaging equipment and space. We also provide expert training and consultation support in research design, neuropsychological test selection, integration with neuroimaging, and flexible approaches to data management in order to support clinical investigators that will lead to improved outcomes for individuals with brain and behavioral conditions. Current studies supported include investigations of novel interventions and mechanisms of recovery from brain injury and stroke.

KEY PERSONNEL

Richard Campbell, PhD
Core Co-Director

Ronald Yeo, PhD
Core Co-Director

Darbi Gill, MS
Research Coordinator

SERVICESNeuropsychology Core

  • Training and Consultation in neuropsychological assessment and research design
  • Electroencephalography (EEG) Suite
  • Transcranial Direct Current Stimulation (tDCS)
  • Functional Near-Infrared Spectroscopy (fNIR or fNIRS)
  • Four Testing/Assessment Rooms
  • Neuropsychological Test Library

Frequently Asked Questions

Q. What neuropsychological tests are in the Clinical Core library?
A. 
Our Neuropsychological Test Library has state-of-the-art tests of intellectual (e.g., WAIS-IV, WISC-V) and cognitive function (e.g., memory, language, attention/executive), including computerized neuropsychological measures (e.g., NIH Toolbox and Examiner). 

Q: What brain conditions does the Clinical Core specialize in?
A: 
We currently support research projects in mild traumatic brain injury, stroke, prematurity/low birth weight, cerebral cavernous malformations, and juvenile myotonic dystrophy. We are interested in supporting researchers interested in other types of brain injury and neurodevelopmental disorders.

Q: What innovative technologies does the Clinical Core provide?
A: 
We have cutting-edge high-definition tDCS equipment and software for intervention studies. We also have functional near-infrared spectroscopy for functional neuroimaging. Additionally, our facility is adjacent to the Mind Research Network (MRN), which is a world-class neuroimaging research center that we strongly collaborate with in order to support multimodal clinical neuroscience investigations.